Combining cell-free RNA with cell-free DNA in liquid biopsy for hematologic and solid tumors

Combining cell-free RNA with cell-free DNA in liquid biopsy for hematologic and solid tumors

Current use of liquid biopsy is based on cell-free DNA (cfDNA) and the evaluation of mutations or methylation pattern. However, expressed RNA can capture mutations, changes in expression levels due to methylation, and provide information on cell of origin, growth, and proliferation status. We develo...

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Bibliographic Details
Main Authors: Maher Albitar, Hong Zhang, Ahmad Charifa, Andrew Ip, Wanlong Ma, James McCloskey, Michele Donato, David Siegel, Stanley Waintraub, Martin Gutierrez, Andrew Pecora, Andre Goy
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Heliyon
Subjects:
Liquid biopsy
Cell-free DNA
Cell-free RNA
Biomarkers
Mutations
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023034680

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http://www.sciencedirect.com/science/article/pii/S2405844023034680

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