On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective
Despite growing attention, antibiotics (such as streptomycin, oxytetracycline or kasugamycin) are still used worldwide for the control of major bacterial plant diseases. This raises concerns on their potential, yet unknown impact on antibiotic and multidrug resistances and the spread of their geneti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1221478/full |
| _version_ | 1797794333320019968 |
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| author | Marie Verhaegen Thomas Bergot Ernesto Liebana Giuseppe Stancanelli Franz Streissl Marie-Paule Mingeot-Leclercq Jacques Mahillon Claude Bragard |
| author_facet | Marie Verhaegen Thomas Bergot Ernesto Liebana Giuseppe Stancanelli Franz Streissl Marie-Paule Mingeot-Leclercq Jacques Mahillon Claude Bragard |
| author_sort | Marie Verhaegen |
| collection | DOAJ |
| description | Despite growing attention, antibiotics (such as streptomycin, oxytetracycline or kasugamycin) are still used worldwide for the control of major bacterial plant diseases. This raises concerns on their potential, yet unknown impact on antibiotic and multidrug resistances and the spread of their genetic determinants among bacterial pathogens. Antibiotic resistance genes (ARGs) have been identified in plant pathogenic bacteria (PPB), with streptomycin resistance genes being the most commonly reported. Therefore, the contribution of mobile genetic elements (MGEs) to their spread among PPB, as well as their ability to transfer to other bacteria, need to be further explored. The only well-documented example of ARGs vector in PPB, Tn5393 and its highly similar variants (carrying streptomycin resistance genes), is concerning because of its presence outside PPB, in Salmonella enterica and Klebsiella pneumoniae, two major human pathogens. Although its structure among PPB is still relatively simple, in human- and animal-associated bacteria, Tn5393 has evolved into complex associations with other MGEs and ARGs. This review sheds light on ARGs and MGEs associated with PPB, but also investigates the potential role of antibiotic use in resistance selection in plant-associated bacteria. |
| first_indexed | 2024-03-13T03:01:15Z |
| format | Article |
| id | doaj.art-0a7cf7ed332547feb322397800309ca4 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T03:01:15Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0a7cf7ed332547feb322397800309ca42023-06-27T11:46:25ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-06-011410.3389/fmicb.2023.12214781221478On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspectiveMarie Verhaegen0Thomas Bergot1Ernesto Liebana2Giuseppe Stancanelli3Franz Streissl4Marie-Paule Mingeot-Leclercq5Jacques Mahillon6Claude Bragard7Laboratory of Food and Environmental Microbiology, Earth and Life Institute, Catholic University of Louvain (UCLouvain), Louvain-la-Neuve, BelgiumLaboratory of Food and Environmental Microbiology, Earth and Life Institute, Catholic University of Louvain (UCLouvain), Louvain-la-Neuve, BelgiumEuropean Food Safety Authority (EFSA), Parma, ItalyEuropean Food Safety Authority (EFSA), Parma, ItalyEuropean Food Safety Authority (EFSA), Parma, ItalyCellular and Molecular Pharmacology Unit, Louvain Drug Research Institute, UCLouvain, Woluwe-Saint-Lambert, BelgiumLaboratory of Food and Environmental Microbiology, Earth and Life Institute, Catholic University of Louvain (UCLouvain), Louvain-la-Neuve, BelgiumPlant Health Laboratory, Earth and Life Institute, UCLouvain, Louvain-la-Neuve, BelgiumDespite growing attention, antibiotics (such as streptomycin, oxytetracycline or kasugamycin) are still used worldwide for the control of major bacterial plant diseases. This raises concerns on their potential, yet unknown impact on antibiotic and multidrug resistances and the spread of their genetic determinants among bacterial pathogens. Antibiotic resistance genes (ARGs) have been identified in plant pathogenic bacteria (PPB), with streptomycin resistance genes being the most commonly reported. Therefore, the contribution of mobile genetic elements (MGEs) to their spread among PPB, as well as their ability to transfer to other bacteria, need to be further explored. The only well-documented example of ARGs vector in PPB, Tn5393 and its highly similar variants (carrying streptomycin resistance genes), is concerning because of its presence outside PPB, in Salmonella enterica and Klebsiella pneumoniae, two major human pathogens. Although its structure among PPB is still relatively simple, in human- and animal-associated bacteria, Tn5393 has evolved into complex associations with other MGEs and ARGs. This review sheds light on ARGs and MGEs associated with PPB, but also investigates the potential role of antibiotic use in resistance selection in plant-associated bacteria.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1221478/fullantibiotic resistanceErwinia amylovorahorizontal gene transferone healthplant pathogenic bacteriastrA-strB |
| spellingShingle | Marie Verhaegen Thomas Bergot Ernesto Liebana Giuseppe Stancanelli Franz Streissl Marie-Paule Mingeot-Leclercq Jacques Mahillon Claude Bragard On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective Frontiers in Microbiology antibiotic resistance Erwinia amylovora horizontal gene transfer one health plant pathogenic bacteria strA-strB |
| title | On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective |
| title_full | On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective |
| title_fullStr | On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective |
| title_full_unstemmed | On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective |
| title_short | On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective |
| title_sort | on the use of antibiotics to control plant pathogenic bacteria a genetic and genomic perspective |
| topic | antibiotic resistance Erwinia amylovora horizontal gene transfer one health plant pathogenic bacteria strA-strB |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1221478/full |
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