Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2018-03-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | http://www.revistas.usp.br/autopsy/article/view/147143 |
| _version_ | 1828420865983774720 |
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| author | Cristiano Claudino Oliveira Rafael Bispo Paschoalini Maria Aparecida Custódio Domingues |
| author_facet | Cristiano Claudino Oliveira Rafael Bispo Paschoalini Maria Aparecida Custódio Domingues |
| author_sort | Cristiano Claudino Oliveira |
| collection | DOAJ |
| description | Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection. |
| first_indexed | 2024-12-10T15:21:06Z |
| format | Article |
| id | doaj.art-0a7d96b46eeb4ea7ab0e38ac9fd3e498 |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-10T15:21:06Z |
| publishDate | 2018-03-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-0a7d96b46eeb4ea7ab0e38ac9fd3e4982022-12-22T01:43:41ZengUniversity of São PauloAutopsy and Case Reports2236-19602018-03-018110.4322/acr.2018.001Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?Cristiano Claudino Oliveira0Rafael Bispo PaschoaliniMaria Aparecida Custódio Domingues1São Paulo State University (UNESP), Botucatu School of Medicine (FMB), Department of PathologySão Paulo State University (UNESP), Botucatu School of Medicine (FMB), Department of PathologyHistiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection.http://www.revistas.usp.br/autopsy/article/view/147143Histiocytic sarcomaDiagnosisImmunohistochemistry. |
| spellingShingle | Cristiano Claudino Oliveira Rafael Bispo Paschoalini Maria Aparecida Custódio Domingues Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? Autopsy and Case Reports Histiocytic sarcoma Diagnosis Immunohistochemistry. |
| title | Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? |
| title_full | Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? |
| title_fullStr | Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? |
| title_full_unstemmed | Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? |
| title_short | Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? |
| title_sort | fas ligand and caspase 3 positivity in three cases of histiocytic sarcoma a different etiopathogenic pathway |
| topic | Histiocytic sarcoma Diagnosis Immunohistochemistry. |
| url | http://www.revistas.usp.br/autopsy/article/view/147143 |
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