Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy
The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence and progression of multiple liver diseases, including alcohol-related liver disease, nonalcoholic fatty liver disease, autoimmune liver disease and l...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086078/full |
| _version_ | 1828045065650438144 |
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| author | Li-Ran Zhu Li-Ran Zhu Shan-Shan Li Wan-Qun Zheng Wei-Jian Ni Wei-Jian Ni Ming Cai Ming Cai Hai-Peng Liu |
| author_facet | Li-Ran Zhu Li-Ran Zhu Shan-Shan Li Wan-Qun Zheng Wei-Jian Ni Wei-Jian Ni Ming Cai Ming Cai Hai-Peng Liu |
| author_sort | Li-Ran Zhu |
| collection | DOAJ |
| description | The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence and progression of multiple liver diseases, including alcohol-related liver disease, nonalcoholic fatty liver disease, autoimmune liver disease and liver cancer. Given the therapeutic status of these diseases, their prevention and early therapy are crucial, and the detailed mechanism of gut microbiota in liver disease urgently needs to be explored. Meanwhile, multiple studies have shown that various traditional Chinese medicines, such as Si Miao Formula, Jiangzhi Granules, Liushen Capsules, Chaihu-Shugan Power, Cassiae Semen and Gynostemma, as well as some natural products, including Costunolide, Coprinus comatus polysaccharide, Antarctic krill oil, Oridonin and Berberine, can repair liver injury, improve fatty liver, regulate liver immunity, and even inhibit liver cancer through multiple targets, links, and pathways. Intriguingly, the aforementioned effects demonstrated by these traditional Chinese medicines and natural products have been shown to be closely related to the gut microbiota, directly driving the strategy of traditional Chinese medicines and natural products to regulate the gut microbiota as one of the breakthroughs in the treatment of liver diseases. Based on this, this review comprehensively summarizes and discusses the characteristics, functions and potential mechanisms of these medicines targeting gut microbiota during liver disease treatment. Research on the potential effects on gut microbiota and the regulatory mechanisms of traditional Chinese medicine and natural products provides novel insights and significant references for developing liver disease treatment strategies. In parallel, such explorations will enhance the comprehension of traditional Chinese medicine and natural products modulating gut microbiota during disease treatment, thus facilitating their clinical investigation and application. |
| first_indexed | 2024-04-10T18:05:37Z |
| format | Article |
| id | doaj.art-0a80301df0a0465cabd86e7134df7977 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T18:05:37Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0a80301df0a0465cabd86e7134df79772023-02-02T13:12:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.10860781086078Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapyLi-Ran Zhu0Li-Ran Zhu1Shan-Shan Li2Wan-Qun Zheng3Wei-Jian Ni4Wei-Jian Ni5Ming Cai6Ming Cai7Hai-Peng Liu8Anhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, ChinaDepartment of Scientific Research and Education, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaDepartment of Chinese Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Pharmacy, Anhui Provincial Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Pharmacy, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, ChinaAnhui Acupuncture and Moxibustion Clinical Medicine Research Center, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, ChinaAnhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaThe gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence and progression of multiple liver diseases, including alcohol-related liver disease, nonalcoholic fatty liver disease, autoimmune liver disease and liver cancer. Given the therapeutic status of these diseases, their prevention and early therapy are crucial, and the detailed mechanism of gut microbiota in liver disease urgently needs to be explored. Meanwhile, multiple studies have shown that various traditional Chinese medicines, such as Si Miao Formula, Jiangzhi Granules, Liushen Capsules, Chaihu-Shugan Power, Cassiae Semen and Gynostemma, as well as some natural products, including Costunolide, Coprinus comatus polysaccharide, Antarctic krill oil, Oridonin and Berberine, can repair liver injury, improve fatty liver, regulate liver immunity, and even inhibit liver cancer through multiple targets, links, and pathways. Intriguingly, the aforementioned effects demonstrated by these traditional Chinese medicines and natural products have been shown to be closely related to the gut microbiota, directly driving the strategy of traditional Chinese medicines and natural products to regulate the gut microbiota as one of the breakthroughs in the treatment of liver diseases. Based on this, this review comprehensively summarizes and discusses the characteristics, functions and potential mechanisms of these medicines targeting gut microbiota during liver disease treatment. Research on the potential effects on gut microbiota and the regulatory mechanisms of traditional Chinese medicine and natural products provides novel insights and significant references for developing liver disease treatment strategies. In parallel, such explorations will enhance the comprehension of traditional Chinese medicine and natural products modulating gut microbiota during disease treatment, thus facilitating their clinical investigation and application.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086078/fullliver diseasegut microbiotatraditional Chinese medicinenatural producttherapeutic strategy |
| spellingShingle | Li-Ran Zhu Li-Ran Zhu Shan-Shan Li Wan-Qun Zheng Wei-Jian Ni Wei-Jian Ni Ming Cai Ming Cai Hai-Peng Liu Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy Frontiers in Immunology liver disease gut microbiota traditional Chinese medicine natural product therapeutic strategy |
| title | Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy |
| title_full | Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy |
| title_fullStr | Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy |
| title_full_unstemmed | Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy |
| title_short | Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy |
| title_sort | targeted modulation of gut microbiota by traditional chinese medicine and natural products for liver disease therapy |
| topic | liver disease gut microbiota traditional Chinese medicine natural product therapeutic strategy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086078/full |
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