Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL)
Background: Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry wi...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-11-01
|
| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630821000823 |
| _version_ | 1818983245188956160 |
|---|---|
| author | Jeremiah de Leon Amanda Woods Tania Twentyman Michael Meade Vicki Sproule Smitha Chandran Joseph Christiansen Neil Kennedy Maria Marney Kris Barooshian Michael Plit Jayd Lynch Raj Jagavkar Helen Ormandy John Christodouleas Florian Pietzsch Michael Chan Michael G Jameson |
| author_facet | Jeremiah de Leon Amanda Woods Tania Twentyman Michael Meade Vicki Sproule Smitha Chandran Joseph Christiansen Neil Kennedy Maria Marney Kris Barooshian Michael Plit Jayd Lynch Raj Jagavkar Helen Ormandy John Christodouleas Florian Pietzsch Michael Chan Michael G Jameson |
| author_sort | Jeremiah de Leon |
| collection | DOAJ |
| description | Background: Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry will provide a linked repository of technical and clinical data that will form a platform for prospective studies and technology assessment. Methods: Design: This registry aims to include an estimated 10,000 eligible participants across Australia and other countries over a 7- to 10-year period. Participants will undergo treatment and assessments in accordance with standard practice. Toxicity and survival outcomes will be assessed at baseline, during treatment, and with 3 monthly follow-up until 24 months, patient reported outcome measures will also be collected. Participants with a variety of cancers will be included. Discussion: Data obtained from the ADAPT-MRL registry is expected to provide evidence on the safety and efficacy of the MR-Linac, a new technical innovation in radiation oncology. We expect this registry will generate data that will be used to optimise treatment techniques, MR-Linac software algorithms, evaluate participants’ outcomes and toxicities and to create a repository of adapted plans, anatomical and functional MR sequences linked to participants’ outcomes. |
| first_indexed | 2024-12-20T18:00:02Z |
| format | Article |
| id | doaj.art-0a826af282064213821d44a372e54bdc |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-12-20T18:00:02Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-0a826af282064213821d44a372e54bdc2022-12-21T19:30:39ZengElsevierClinical and Translational Radiation Oncology2405-63082021-11-01316470Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL)Jeremiah de Leon0Amanda Woods1Tania Twentyman2Michael Meade3Vicki Sproule4Smitha Chandran5Joseph Christiansen6Neil Kennedy7Maria Marney8Kris Barooshian9Michael Plit10Jayd Lynch11Raj Jagavkar12Helen Ormandy13John Christodouleas14Florian Pietzsch15Michael Chan16Michael G Jameson17GenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaElekta AB, Stockholm, Sweden; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, USAGenesisCare, Sydney, AustraliaGenesisCare, Sydney, AustraliaGenesisCare, Sydney, Australia; University of New South Wales, Sydney, Australia; Corresponding author at: GenesisCare, Buildings 1 & 11, The Mill, 41-43 Bourke Road, Alexandria, NSW 2015, Australia.Background: Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry will provide a linked repository of technical and clinical data that will form a platform for prospective studies and technology assessment. Methods: Design: This registry aims to include an estimated 10,000 eligible participants across Australia and other countries over a 7- to 10-year period. Participants will undergo treatment and assessments in accordance with standard practice. Toxicity and survival outcomes will be assessed at baseline, during treatment, and with 3 monthly follow-up until 24 months, patient reported outcome measures will also be collected. Participants with a variety of cancers will be included. Discussion: Data obtained from the ADAPT-MRL registry is expected to provide evidence on the safety and efficacy of the MR-Linac, a new technical innovation in radiation oncology. We expect this registry will generate data that will be used to optimise treatment techniques, MR-Linac software algorithms, evaluate participants’ outcomes and toxicities and to create a repository of adapted plans, anatomical and functional MR sequences linked to participants’ outcomes.http://www.sciencedirect.com/science/article/pii/S2405630821000823ADAPT-MRLRegistryMR-LinacMRIRadiotherapy |
| spellingShingle | Jeremiah de Leon Amanda Woods Tania Twentyman Michael Meade Vicki Sproule Smitha Chandran Joseph Christiansen Neil Kennedy Maria Marney Kris Barooshian Michael Plit Jayd Lynch Raj Jagavkar Helen Ormandy John Christodouleas Florian Pietzsch Michael Chan Michael G Jameson Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) Clinical and Translational Radiation Oncology ADAPT-MRL Registry MR-Linac MRI Radiotherapy |
| title | Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) |
| title_full | Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) |
| title_fullStr | Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) |
| title_full_unstemmed | Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) |
| title_short | Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) |
| title_sort | analysis of data to advance personalised therapy with mr linac adapt mrl |
| topic | ADAPT-MRL Registry MR-Linac MRI Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405630821000823 |
| work_keys_str_mv | AT jeremiahdeleon analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT amandawoods analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT taniatwentyman analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT michaelmeade analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT vickisproule analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT smithachandran analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT josephchristiansen analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT neilkennedy analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT mariamarney analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT krisbarooshian analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT michaelplit analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT jaydlynch analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT rajjagavkar analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT helenormandy analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT johnchristodouleas analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT florianpietzsch analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT michaelchan analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl AT michaelgjameson analysisofdatatoadvancepersonalisedtherapywithmrlinacadaptmrl |