Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis
Abstract No clinical study has compared lung or lobe volumes on computed tomography (CT) between the supine and standing positions in patients with idiopathic lung fibrosis (IPF). This study aimed to compare lung and lobe volumes between the supine and standing positions and evaluate the correlation...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-24157-x |
| _version_ | 1817970497266122752 |
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| author | Shotaro Chubachi Satoshi Okamori Yoshitake Yamada Minoru Yamada Yoichi Yokoyama Yuki Niijima Hirofumi Kamata Makoto Ishii Koichi Fukunaga Masahiro Jinzaki |
| author_facet | Shotaro Chubachi Satoshi Okamori Yoshitake Yamada Minoru Yamada Yoichi Yokoyama Yuki Niijima Hirofumi Kamata Makoto Ishii Koichi Fukunaga Masahiro Jinzaki |
| author_sort | Shotaro Chubachi |
| collection | DOAJ |
| description | Abstract No clinical study has compared lung or lobe volumes on computed tomography (CT) between the supine and standing positions in patients with idiopathic lung fibrosis (IPF). This study aimed to compare lung and lobe volumes between the supine and standing positions and evaluate the correlations between the supine/standing lung volumes on CT and pulmonary function in patients with IPF. Twenty-three patients with IPF underwent a pulmonary function test and both low-dose conventional (supine position) and upright CT (standing position) during inspiration breath-holds. The volumes of the total lungs and lobes were larger in the standing than in the supine position in patients with IPF (all p < 0.05). Spearman's correlation coefficients between total lung volumes on chest CT in supine/standing positions and vital capacity (VC) or forced VC (FVC) were 0.61/0.79 or 0.64/0.80, respectively. CT-based volumes on upright CT were better correlated with VC and FVC than those on supine CT. Lung and lobe volumes in the standing position may be useful biomarkers to assess disease severity or therapeutic effect in patients with IPF. |
| first_indexed | 2024-04-13T20:35:52Z |
| format | Article |
| id | doaj.art-0a840bf380ad4c64a74bbf8f014a8812 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T20:35:52Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0a840bf380ad4c64a74bbf8f014a88122022-12-22T02:31:03ZengNature PortfolioScientific Reports2045-23222022-11-011211810.1038/s41598-022-24157-xDifferences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosisShotaro Chubachi0Satoshi Okamori1Yoshitake Yamada2Minoru Yamada3Yoichi Yokoyama4Yuki Niijima5Hirofumi Kamata6Makoto Ishii7Koichi Fukunaga8Masahiro Jinzaki9Division of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineOffice of Radiation Technology, Keio University HospitalDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineAbstract No clinical study has compared lung or lobe volumes on computed tomography (CT) between the supine and standing positions in patients with idiopathic lung fibrosis (IPF). This study aimed to compare lung and lobe volumes between the supine and standing positions and evaluate the correlations between the supine/standing lung volumes on CT and pulmonary function in patients with IPF. Twenty-three patients with IPF underwent a pulmonary function test and both low-dose conventional (supine position) and upright CT (standing position) during inspiration breath-holds. The volumes of the total lungs and lobes were larger in the standing than in the supine position in patients with IPF (all p < 0.05). Spearman's correlation coefficients between total lung volumes on chest CT in supine/standing positions and vital capacity (VC) or forced VC (FVC) were 0.61/0.79 or 0.64/0.80, respectively. CT-based volumes on upright CT were better correlated with VC and FVC than those on supine CT. Lung and lobe volumes in the standing position may be useful biomarkers to assess disease severity or therapeutic effect in patients with IPF.https://doi.org/10.1038/s41598-022-24157-x |
| spellingShingle | Shotaro Chubachi Satoshi Okamori Yoshitake Yamada Minoru Yamada Yoichi Yokoyama Yuki Niijima Hirofumi Kamata Makoto Ishii Koichi Fukunaga Masahiro Jinzaki Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis Scientific Reports |
| title | Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis |
| title_full | Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis |
| title_fullStr | Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis |
| title_full_unstemmed | Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis |
| title_short | Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis |
| title_sort | differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis |
| url | https://doi.org/10.1038/s41598-022-24157-x |
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