Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants
Background. KL-6 is a biomarker of interstitial lung injury and increases during repair. Aim. Our aim was to determine the predictive value of plasma KL-6 for the development of bronchopulmonary dysplasia (BPD) in preterm infants. Methods. Ninety-five extremely preterm infants (EPIs), born at <28...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2024-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2024/3623948 |
| _version_ | 1797322537680502784 |
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| author | Petya Radulova Margaritka Boncheva Gencho Nachev Boriana Slancheva Violeta Dimitrova |
| author_facet | Petya Radulova Margaritka Boncheva Gencho Nachev Boriana Slancheva Violeta Dimitrova |
| author_sort | Petya Radulova |
| collection | DOAJ |
| description | Background. KL-6 is a biomarker of interstitial lung injury and increases during repair. Aim. Our aim was to determine the predictive value of plasma KL-6 for the development of bronchopulmonary dysplasia (BPD) in preterm infants. Methods. Ninety-five extremely preterm infants (EPIs), born at <28 gestational age (GA), were divided into two main BPD groups as follows: the moderate/severe and the no/mild group. KL-6 was analyzed on days 7 and 14. Binary logistic regression analyses and ROC curve analyses were performed. Results. Infants <26 + 0 weeks’ GA have higher mean KL-6 than infants >25 + 6 weeks’ GA on 7 and 14 days (335 vs. 286 U/ml and 378 vs. 260 U/ml; p=0.005 and 0.018, respectively). In the binary regression model at KL-6 day 7, three of the prognostic factors remained significant—mechanical ventilation OR: 10.38 (95% CI: 3.57–30.14), PDA OR: 6.39 (95% CI: 0.87–46.74), and KL-6 OR: 4.98 (95% CI: 1.54–16.08). The AUC was 0.86 with a sensitivity and specificity of 79% at a cutoff value ≥0.34. In the binary regression model at KL-6 day 14, six of the prognostic factors were significant—PDA OR: 23.34 (95% CI: 2.14–254.24), KL-6 OR: 13.59 (95% CI: 3.19–57.96), GA OR: 4.58 (95% CI: 1.16–18.06), mechanical ventilation OR: 4.45 (95% CI: 1.23–16.16), antenatal steroids OR: 0.19 (95% CI: 0.04–0.95), and gender (female OR: 0.30 (95% CI 0.08–1.12)). The AUC was 0.91, and the sensitivity and accuracy for a cutoff ≥0.37 were 89% and 85%, respectively. Conclusion. KL-6 could be a useful screening biomarker for early detection of infants at increased risk for developing BPD. |
| first_indexed | 2024-03-08T05:15:44Z |
| format | Article |
| id | doaj.art-0a849a7b348b4721b7a50d0390de6e5f |
| institution | Directory Open Access Journal |
| issn | 2090-1313 |
| language | English |
| last_indexed | 2024-03-08T05:15:44Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj.art-0a849a7b348b4721b7a50d0390de6e5f2024-02-07T00:00:11ZengHindawi LimitedCritical Care Research and Practice2090-13132024-01-01202410.1155/2024/3623948Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm InfantsPetya Radulova0Margaritka Boncheva1Gencho Nachev2Boriana Slancheva3Violeta Dimitrova4Department of Obstetrics and GynecologyUniversity Hospital for Active Treatment “St. Ekaterina”University Hospital for Active Treatment “St. Ekaterina”Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyBackground. KL-6 is a biomarker of interstitial lung injury and increases during repair. Aim. Our aim was to determine the predictive value of plasma KL-6 for the development of bronchopulmonary dysplasia (BPD) in preterm infants. Methods. Ninety-five extremely preterm infants (EPIs), born at <28 gestational age (GA), were divided into two main BPD groups as follows: the moderate/severe and the no/mild group. KL-6 was analyzed on days 7 and 14. Binary logistic regression analyses and ROC curve analyses were performed. Results. Infants <26 + 0 weeks’ GA have higher mean KL-6 than infants >25 + 6 weeks’ GA on 7 and 14 days (335 vs. 286 U/ml and 378 vs. 260 U/ml; p=0.005 and 0.018, respectively). In the binary regression model at KL-6 day 7, three of the prognostic factors remained significant—mechanical ventilation OR: 10.38 (95% CI: 3.57–30.14), PDA OR: 6.39 (95% CI: 0.87–46.74), and KL-6 OR: 4.98 (95% CI: 1.54–16.08). The AUC was 0.86 with a sensitivity and specificity of 79% at a cutoff value ≥0.34. In the binary regression model at KL-6 day 14, six of the prognostic factors were significant—PDA OR: 23.34 (95% CI: 2.14–254.24), KL-6 OR: 13.59 (95% CI: 3.19–57.96), GA OR: 4.58 (95% CI: 1.16–18.06), mechanical ventilation OR: 4.45 (95% CI: 1.23–16.16), antenatal steroids OR: 0.19 (95% CI: 0.04–0.95), and gender (female OR: 0.30 (95% CI 0.08–1.12)). The AUC was 0.91, and the sensitivity and accuracy for a cutoff ≥0.37 were 89% and 85%, respectively. Conclusion. KL-6 could be a useful screening biomarker for early detection of infants at increased risk for developing BPD.http://dx.doi.org/10.1155/2024/3623948 |
| spellingShingle | Petya Radulova Margaritka Boncheva Gencho Nachev Boriana Slancheva Violeta Dimitrova Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants Critical Care Research and Practice |
| title | Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants |
| title_full | Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants |
| title_fullStr | Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants |
| title_full_unstemmed | Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants |
| title_short | Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants |
| title_sort | plasma kl 6 as a potential biomarker for bronchopulmonary dysplasia in preterm infants |
| url | http://dx.doi.org/10.1155/2024/3623948 |
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