The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases
The world’s population is in a demographical transition, with an increase in the number of older adults and prevalence of diseases related to aging. This study evaluated in vitro the potential of using <i>Durvillaea incurvata</i> extract (extracted using ultrasound-assisted extraction) t...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/2/269 |
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| author | Nicolás Muñoz-Molina Javier Parada Mario Simirgiotis Romina Montecinos-González |
| author_facet | Nicolás Muñoz-Molina Javier Parada Mario Simirgiotis Romina Montecinos-González |
| author_sort | Nicolás Muñoz-Molina |
| collection | DOAJ |
| description | The world’s population is in a demographical transition, with an increase in the number of older adults and prevalence of diseases related to aging. This study evaluated in vitro the potential of using <i>Durvillaea incurvata</i> extract (extracted using ultrasound-assisted extraction) to inhibit key enzymes associated with the development of age-related diseases. Our results show that an extract extracted via ultrasound-assisted extracted, as well as an extract conventional extracted from <i>Durvillaea incurvata,</i> presented antidiabetes potential by exhibiting inhibitory activity against α-glucosidase (91.8 ± 1.0% and 93.8 ± 0.3%, respectively, at 500 µg/mL) and α-amylase (42.2 ± 1.4% and 61.9 ± 0.9%, respectively, at 1500 µg/mL) enzymes related to starch digestion and postprandial glycemic response. Also, the extracts showed inhibitory activity against the enzymes acetylcholinesterase (51.5% and 50.8%, respectively, at 500 µg/mL) and butyrylcholinesterase (32.8% and 34.4%, respectively, at 0.5 mg/mL), the biomarkers associated with Alzheimer’s disease, and angiotensin-converting enzyme (98.7 ± 7.4% and 93.0 ± 3.4%, respectively, at 2.0 mg/mL), which is key in the regulation of vascular tone and blood pressure and helps to prevent the development of hypertension. In conclusion, the extract of <i>Durvillaea incurvata</i> obtained from ultrasound-assisted extraction has the potential to prevent the development of age-related pathologies such as diabetes, Alzheimer’s disease, and hypertension. |
| first_indexed | 2024-03-08T09:54:31Z |
| format | Article |
| id | doaj.art-0a8519d6683043a4b1e2bf12df85f2f3 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-08T09:54:31Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-0a8519d6683043a4b1e2bf12df85f2f32024-01-29T13:52:20ZengMDPI AGFoods2304-81582024-01-0113226910.3390/foods13020269The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related DiseasesNicolás Muñoz-Molina0Javier Parada1Mario Simirgiotis2Romina Montecinos-González3Graduate School, Faculty of Agricultural and Food Sciences, Universidad Austral de Chile, Valdivia 5090000, ChileInstitute of Food Science and Technology, Faculty of Agricultural and Food Sciences, Universidad Austral de Chile, Valdivia 5090000, ChileInstituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, ChileInstitute of Food Science and Technology, Faculty of Agricultural and Food Sciences, Universidad Austral de Chile, Valdivia 5090000, ChileThe world’s population is in a demographical transition, with an increase in the number of older adults and prevalence of diseases related to aging. This study evaluated in vitro the potential of using <i>Durvillaea incurvata</i> extract (extracted using ultrasound-assisted extraction) to inhibit key enzymes associated with the development of age-related diseases. Our results show that an extract extracted via ultrasound-assisted extracted, as well as an extract conventional extracted from <i>Durvillaea incurvata,</i> presented antidiabetes potential by exhibiting inhibitory activity against α-glucosidase (91.8 ± 1.0% and 93.8 ± 0.3%, respectively, at 500 µg/mL) and α-amylase (42.2 ± 1.4% and 61.9 ± 0.9%, respectively, at 1500 µg/mL) enzymes related to starch digestion and postprandial glycemic response. Also, the extracts showed inhibitory activity against the enzymes acetylcholinesterase (51.5% and 50.8%, respectively, at 500 µg/mL) and butyrylcholinesterase (32.8% and 34.4%, respectively, at 0.5 mg/mL), the biomarkers associated with Alzheimer’s disease, and angiotensin-converting enzyme (98.7 ± 7.4% and 93.0 ± 3.4%, respectively, at 2.0 mg/mL), which is key in the regulation of vascular tone and blood pressure and helps to prevent the development of hypertension. In conclusion, the extract of <i>Durvillaea incurvata</i> obtained from ultrasound-assisted extraction has the potential to prevent the development of age-related pathologies such as diabetes, Alzheimer’s disease, and hypertension.https://www.mdpi.com/2304-8158/13/2/269<i>Durvillaea incurvata</i>agingenzyme inhibitionAlzheimer’sdiabeteshypertension |
| spellingShingle | Nicolás Muñoz-Molina Javier Parada Mario Simirgiotis Romina Montecinos-González The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases Foods <i>Durvillaea incurvata</i> aging enzyme inhibition Alzheimer’s diabetes hypertension |
| title | The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases |
| title_full | The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases |
| title_fullStr | The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases |
| title_full_unstemmed | The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases |
| title_short | The Potential of Using Cochayuyo (<i>Durvillaea incurvata</i>) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases |
| title_sort | potential of using cochayuyo i durvillaea incurvata i extract obtained by ultrasound assisted extraction to fight against aging related diseases |
| topic | <i>Durvillaea incurvata</i> aging enzyme inhibition Alzheimer’s diabetes hypertension |
| url | https://www.mdpi.com/2304-8158/13/2/269 |
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