Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide

Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide

Antisense oligonucleotides (ASONs) have proven potential for the treatment of various diseases. However, their limited bioavailability restricts their clinical application. New structures with improved enzyme resistance stability and efficient drug delivery are needed. In this work, we propose a nov...

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Bibliographic Details
Main Authors: Zhe Zhang, Zuyi Chen, Cheng Li, Zhenyu Xiao, Yuan Luo, Xiaochen Pan, Liang Xu, Xuesong Feng
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
oligonucleotide conjugation
anisamide
anti-enzymatic stability
cellular uptake
antitumor activity
Online Access:https://www.mdpi.com/1999-4923/15/6/1645

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