The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring
<b>Background</b>: Chorioamnionitis during labor exposes the fetus to an intrauterine state that may alter the future immune response and may expose the offspring to future susceptibility to infectious disease. We evaluated the long-term pediatric infectious morbidity of children born at...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/3/814 |
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| author | Noa Efrat Davidi Gil Gutvirtz Eyal Sheiner |
| author_facet | Noa Efrat Davidi Gil Gutvirtz Eyal Sheiner |
| author_sort | Noa Efrat Davidi |
| collection | DOAJ |
| description | <b>Background</b>: Chorioamnionitis during labor exposes the fetus to an intrauterine state that may alter the future immune response and may expose the offspring to future susceptibility to infectious disease. We evaluated the long-term pediatric infectious morbidity of children born at term to mothers who have chorioamnionitis during labor. <b>Methods:</b> This was a population-based cohort analysis including only term singleton deliveries at a regional tertiary hospital between the years 1991 and 2021. Offspring to mothers with and without a diagnosis of chorioamnionitis during labor were compared. Offspring hospitalizations up to the age of 18 years involving infectious morbidity were evaluated using the Kaplan–Meier survival curve and a Cox regression model to control possible confounders. <b>Results:</b> A total of 331,598 deliveries were included, 988 (0.3%) of which were of mothers diagnosed with chorioamnionitis during labor. All infectious morbidity rates included in the analysis were comparable between groups. The Kaplan–Meier survival curves were similar for both groups (log-rank = 0.881) and the multivariable analysis ascertained that chorioamnionitis during labor was not a risk factor for offspring’s long-term infectious morbidity (HR 0.929, 95%CI 0.818–1.054, <i>p</i> = 0.254). <b>Conclusions:</b> In our cohort, term chorioamnionitis during labor was not associated with a higher risk of pediatric hospitalization due to infections. The infectious/inflammatory state during labor did not expose nor increase the susceptibility of the term offspring to future infectious morbidity. |
| first_indexed | 2024-03-08T03:53:19Z |
| format | Article |
| id | doaj.art-0a873c39650644a2a19bae907453a15d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:53:19Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0a873c39650644a2a19bae907453a15d2024-02-09T15:16:12ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113381410.3390/jcm13030814The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the OffspringNoa Efrat Davidi0Gil Gutvirtz1Eyal Sheiner2Faculty of Health Sciences, Joyce and Irving Goldman Medical School, Ben Gurion University of the Negev, Beer-Sheva 84105, IsraelFaculty of Health Sciences, Joyce and Irving Goldman Medical School, Ben Gurion University of the Negev, Beer-Sheva 84105, IsraelFaculty of Health Sciences, Joyce and Irving Goldman Medical School, Ben Gurion University of the Negev, Beer-Sheva 84105, Israel<b>Background</b>: Chorioamnionitis during labor exposes the fetus to an intrauterine state that may alter the future immune response and may expose the offspring to future susceptibility to infectious disease. We evaluated the long-term pediatric infectious morbidity of children born at term to mothers who have chorioamnionitis during labor. <b>Methods:</b> This was a population-based cohort analysis including only term singleton deliveries at a regional tertiary hospital between the years 1991 and 2021. Offspring to mothers with and without a diagnosis of chorioamnionitis during labor were compared. Offspring hospitalizations up to the age of 18 years involving infectious morbidity were evaluated using the Kaplan–Meier survival curve and a Cox regression model to control possible confounders. <b>Results:</b> A total of 331,598 deliveries were included, 988 (0.3%) of which were of mothers diagnosed with chorioamnionitis during labor. All infectious morbidity rates included in the analysis were comparable between groups. The Kaplan–Meier survival curves were similar for both groups (log-rank = 0.881) and the multivariable analysis ascertained that chorioamnionitis during labor was not a risk factor for offspring’s long-term infectious morbidity (HR 0.929, 95%CI 0.818–1.054, <i>p</i> = 0.254). <b>Conclusions:</b> In our cohort, term chorioamnionitis during labor was not associated with a higher risk of pediatric hospitalization due to infections. The infectious/inflammatory state during labor did not expose nor increase the susceptibility of the term offspring to future infectious morbidity.https://www.mdpi.com/2077-0383/13/3/814term pregnancychorioamnionitislaborlong-termfollow-upinfectious morbidity |
| spellingShingle | Noa Efrat Davidi Gil Gutvirtz Eyal Sheiner The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring Journal of Clinical Medicine term pregnancy chorioamnionitis labor long-term follow-up infectious morbidity |
| title | The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring |
| title_full | The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring |
| title_fullStr | The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring |
| title_full_unstemmed | The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring |
| title_short | The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring |
| title_sort | association between term chorioamnionitis during labor and long term infectious morbidity of the offspring |
| topic | term pregnancy chorioamnionitis labor long-term follow-up infectious morbidity |
| url | https://www.mdpi.com/2077-0383/13/3/814 |
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