Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT
Abstract Propensity score matching evaluates the treatment incidence of radiation-induced pneumonitis (RP) and secondary cancer risk (SCR) after intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for breast cancer patients. Of 32 patients treated with IMRT and 58 who...
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| Format: | Article |
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Nature Portfolio
2017-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-14145-x |
| _version_ | 1818844045347127296 |
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| author | Pei-Ju Chao Hsiao-Fei Lee Jen-Hong Lan Shih-Sian Guo Hui-Min Ting Yu-Jie Huang Hui-Chun Chen Tsair-Fwu Lee |
| author_facet | Pei-Ju Chao Hsiao-Fei Lee Jen-Hong Lan Shih-Sian Guo Hui-Min Ting Yu-Jie Huang Hui-Chun Chen Tsair-Fwu Lee |
| author_sort | Pei-Ju Chao |
| collection | DOAJ |
| description | Abstract Propensity score matching evaluates the treatment incidence of radiation-induced pneumonitis (RP) and secondary cancer risk (SCR) after intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for breast cancer patients. Of 32 patients treated with IMRT and 58 who received VMAT were propensity matched in a 1:1 ratio. RP and SCR were evaluated as the endpoints of acute and chronic toxicity, respectively. Self-fitted normal tissue complication probability (NTCP) parameter values were used to analyze the risk of RP. SCRs were evaluated using the preferred Schneider’s parameterization risk models. The dosimetric parameter of the ipsilateral lung volume receiving 40 Gy (IV40) was selected as the dominant risk factor for the RP NTCP model. The results showed that the risks of RP and NTCP, as well as that of SCR of the ipsilateral lung, were slightly lower than the values in patients treated with VMAT versus IMRT (p ≤ 0.01). However, the organ equivalent dose and excess absolute risk values in the contralateral lung and breast were slightly higher with VMAT than with IMRT (p ≤ 0.05). When compared to IMRT, VMAT is a rational radiotherapy option for breast cancer patients, based on its reduced potential for inducing secondary malignancies and RP complications. |
| first_indexed | 2024-12-19T05:07:31Z |
| format | Article |
| id | doaj.art-0a87b15e8e394bbbb55579ebb17264a6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:07:31Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0a87b15e8e394bbbb55579ebb17264a62022-12-21T20:34:53ZengNature PortfolioScientific Reports2045-23222017-10-01711910.1038/s41598-017-14145-xPropensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMATPei-Ju Chao0Hsiao-Fei Lee1Jen-Hong Lan2Shih-Sian Guo3Hui-Min Ting4Yu-Jie Huang5Hui-Chun Chen6Tsair-Fwu Lee7Medical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, KaohsiungMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, KaohsiungMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, KaohsiungMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, KaohsiungMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, KaohsiungDepartment of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, KaohsiungDepartment of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, KaohsiungMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, KaohsiungAbstract Propensity score matching evaluates the treatment incidence of radiation-induced pneumonitis (RP) and secondary cancer risk (SCR) after intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for breast cancer patients. Of 32 patients treated with IMRT and 58 who received VMAT were propensity matched in a 1:1 ratio. RP and SCR were evaluated as the endpoints of acute and chronic toxicity, respectively. Self-fitted normal tissue complication probability (NTCP) parameter values were used to analyze the risk of RP. SCRs were evaluated using the preferred Schneider’s parameterization risk models. The dosimetric parameter of the ipsilateral lung volume receiving 40 Gy (IV40) was selected as the dominant risk factor for the RP NTCP model. The results showed that the risks of RP and NTCP, as well as that of SCR of the ipsilateral lung, were slightly lower than the values in patients treated with VMAT versus IMRT (p ≤ 0.01). However, the organ equivalent dose and excess absolute risk values in the contralateral lung and breast were slightly higher with VMAT than with IMRT (p ≤ 0.05). When compared to IMRT, VMAT is a rational radiotherapy option for breast cancer patients, based on its reduced potential for inducing secondary malignancies and RP complications.https://doi.org/10.1038/s41598-017-14145-x |
| spellingShingle | Pei-Ju Chao Hsiao-Fei Lee Jen-Hong Lan Shih-Sian Guo Hui-Min Ting Yu-Jie Huang Hui-Chun Chen Tsair-Fwu Lee Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT Scientific Reports |
| title | Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT |
| title_full | Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT |
| title_fullStr | Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT |
| title_full_unstemmed | Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT |
| title_short | Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT |
| title_sort | propensity score matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with imrt vmat |
| url | https://doi.org/10.1038/s41598-017-14145-x |
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