Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS)...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-12-01
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| Series: | International Journal for Parasitology: Drugs and Drug Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211320714000207 |
| _version_ | 1818474882710634496 |
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| author | Andrew C. Kotze Peter W. Hunt Philip Skuce Georg von Samson-Himmelstjerna Richard J. Martin Heinz Sager Jürgen Krücken Jane Hodgkinson Anne Lespine Aaron R. Jex John S. Gilleard Robin N. Beech Adrian J. Wolstenholme Janina Demeler Alan P. Robertson Claude L. Charvet Cedric Neveu Ronald Kaminsky Lucien Rufener Melanie Alberich Cecile Menez Roger K. Prichard |
| author_facet | Andrew C. Kotze Peter W. Hunt Philip Skuce Georg von Samson-Himmelstjerna Richard J. Martin Heinz Sager Jürgen Krücken Jane Hodgkinson Anne Lespine Aaron R. Jex John S. Gilleard Robin N. Beech Adrian J. Wolstenholme Janina Demeler Alan P. Robertson Claude L. Charvet Cedric Neveu Ronald Kaminsky Lucien Rufener Melanie Alberich Cecile Menez Roger K. Prichard |
| author_sort | Andrew C. Kotze |
| collection | DOAJ |
| description | Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS) provides a forum for scientists to meet and discuss the latest developments in the search for molecular markers of anthelmintic resistance. Such markers are important for detecting drug resistant worm populations, and indicating the likely impact of the resistance on drug efficacy. The molecular basis of resistance is also important for understanding how anthelmintics work, and how drug resistant populations arise. Changes to target receptors, drug efflux and other biological processes can be involved. This paper reports on the CARS group meeting held in August 2013 in Perth, Australia. The latest knowledge on the development of molecular markers for resistance to each of the principal classes of anthelmintics is reviewed. The molecular basis of resistance is best understood for the benzimidazole group of compounds, and we examine recent work to translate this knowledge into useful diagnostics for field use. We examine recent candidate-gene and whole-genome approaches to understanding anthelmintic resistance and identify markers. We also look at drug transporters in terms of providing both useful markers for resistance, as well as opportunities to overcome resistance through the targeting of the transporters themselves with inhibitors. Finally, we describe the tools available for the application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance. |
| first_indexed | 2024-04-14T04:42:23Z |
| format | Article |
| id | doaj.art-0a884c7c4a7c454ea5b5be5fc9a7abce |
| institution | Directory Open Access Journal |
| issn | 2211-3207 |
| language | English |
| last_indexed | 2024-04-14T04:42:23Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal for Parasitology: Drugs and Drug Resistance |
| spelling | doaj.art-0a884c7c4a7c454ea5b5be5fc9a7abce2022-12-22T02:11:35ZengElsevierInternational Journal for Parasitology: Drugs and Drug Resistance2211-32072014-12-014316418410.1016/j.ijpddr.2014.07.007Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactionsAndrew C. Kotze0Peter W. Hunt1Philip Skuce2Georg von Samson-Himmelstjerna3Richard J. Martin4Heinz Sager5Jürgen Krücken6Jane Hodgkinson7Anne Lespine8Aaron R. Jex9John S. Gilleard10Robin N. Beech11Adrian J. Wolstenholme12Janina Demeler13Alan P. Robertson14Claude L. Charvet15Cedric Neveu16Ronald Kaminsky17Lucien Rufener18Melanie Alberich19Cecile Menez20Roger K. Prichard21CSIRO Animal, Food and Health Sciences, Brisbane, QLD, AustraliaCSIRO Animal, Food and Health Sciences, Armidale, NSW, AustraliaParasitology Division, Moredun Research Institute, Penicuik, Midlothian, UKInstitute for Parasitology and Tropical Veterinary Medicine, Freie Universitat Berlin, Berlin, GermanyDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USANovartis Centre de Recherche Sante Animale, St. Aubin, SwitzerlandInstitute for Parasitology and Tropical Veterinary Medicine, Freie Universitat Berlin, Berlin, GermanyVeterinary Parasitology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UKINRA, Toxalim, Research Centre in Food Toxicology, Toulouse, FranceFaculty of Veterinary Science, University of Melbourne, Parkville, VIC, AustraliaFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, CanadaInstitute of Parasitology, McGill University, QC, CanadaDepartment of Infectious Diseases & Center for Tropical and Emerging Global Disease, University of Georgia, Athens, GA, USAInstitute for Parasitology and Tropical Veterinary Medicine, Freie Universitat Berlin, Berlin, GermanyDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USAINRA, Infectiologie et Santé Publique, Nouzilly, FranceINRA, Infectiologie et Santé Publique, Nouzilly, FranceNovartis Centre de Recherche Sante Animale, St. Aubin, SwitzerlandNovartis Centre de Recherche Sante Animale, St. Aubin, SwitzerlandINRA, Toxalim, Research Centre in Food Toxicology, Toulouse, FranceINRA, Toxalim, Research Centre in Food Toxicology, Toulouse, FranceInstitute of Parasitology, McGill University, QC, CanadaAnthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS) provides a forum for scientists to meet and discuss the latest developments in the search for molecular markers of anthelmintic resistance. Such markers are important for detecting drug resistant worm populations, and indicating the likely impact of the resistance on drug efficacy. The molecular basis of resistance is also important for understanding how anthelmintics work, and how drug resistant populations arise. Changes to target receptors, drug efflux and other biological processes can be involved. This paper reports on the CARS group meeting held in August 2013 in Perth, Australia. The latest knowledge on the development of molecular markers for resistance to each of the principal classes of anthelmintics is reviewed. The molecular basis of resistance is best understood for the benzimidazole group of compounds, and we examine recent work to translate this knowledge into useful diagnostics for field use. We examine recent candidate-gene and whole-genome approaches to understanding anthelmintic resistance and identify markers. We also look at drug transporters in terms of providing both useful markers for resistance, as well as opportunities to overcome resistance through the targeting of the transporters themselves with inhibitors. Finally, we describe the tools available for the application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance.http://www.sciencedirect.com/science/article/pii/S2211320714000207Anthelmintic resistanceAnthelmintic drugsMolecular markersAnthelmintic targetsReceptors |
| spellingShingle | Andrew C. Kotze Peter W. Hunt Philip Skuce Georg von Samson-Himmelstjerna Richard J. Martin Heinz Sager Jürgen Krücken Jane Hodgkinson Anne Lespine Aaron R. Jex John S. Gilleard Robin N. Beech Adrian J. Wolstenholme Janina Demeler Alan P. Robertson Claude L. Charvet Cedric Neveu Ronald Kaminsky Lucien Rufener Melanie Alberich Cecile Menez Roger K. Prichard Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions International Journal for Parasitology: Drugs and Drug Resistance Anthelmintic resistance Anthelmintic drugs Molecular markers Anthelmintic targets Receptors |
| title | Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions |
| title_full | Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions |
| title_fullStr | Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions |
| title_full_unstemmed | Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions |
| title_short | Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions |
| title_sort | recent advances in candidate gene and whole genome approaches to the discovery of anthelmintic resistance markers and the description of drug receptor interactions |
| topic | Anthelmintic resistance Anthelmintic drugs Molecular markers Anthelmintic targets Receptors |
| url | http://www.sciencedirect.com/science/article/pii/S2211320714000207 |
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