Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis
Abstract Background It has been shown that iron deficiency anemia (IDA) is associated with psychosocial consequences and psychiatric morbidity. However, the association between adults with IDA and psychiatric disorders has not been clarified. The purpose of this study was to investigate the psychiat...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-020-02621-0 |
| _version_ | 1818325594850459648 |
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| author | Herng-Sheng Lee Hsin-Hao Chao Wan-Ting Huang Solomon Chih-Cheng Chen Hsin-Yi Yang |
| author_facet | Herng-Sheng Lee Hsin-Hao Chao Wan-Ting Huang Solomon Chih-Cheng Chen Hsin-Yi Yang |
| author_sort | Herng-Sheng Lee |
| collection | DOAJ |
| description | Abstract Background It has been shown that iron deficiency anemia (IDA) is associated with psychosocial consequences and psychiatric morbidity. However, the association between adults with IDA and psychiatric disorders has not been clarified. The purpose of this study was to investigate the psychiatric disorder morbidity of an IDA group in comparison with a non-IDA group and to examine the risk of psychiatric disorders in IDA patients treated with iron supplementation. Methods All study subjects were 20 years of age or over with newly diagnosed IDA enrolled in the Taiwan National Health Insurance Database from 2000 to 2012. We matched IDA and non-IDA subjects according to age and gender in a 1:2 ratio. Our primary outcome was diagnosis of psychiatric disorders and the patients were monitored until the end of 2013. A multivariate Cox proportional hazards regression model was used to explore the risk of psychiatric disorders in patients with IDA after adjustment for confounders, including demographic characteristics and comorbidities. Results The adjusted hazard ratios (aHRs) of psychiatric disorders was 1.52 (95% CI = 1.45–1.59) in the IDA group compared with the non-IDA group. Among the different types of psychiatric disorders, the IDA group was associated with significantly higher incidence and risks of anxiety disorders, depression, sleep disorders, and psychotic disorders (p < 0.05). Furthermore, iron supplementation in IDA subjects was associated with a significantly lower risk of psychiatric disorders compared to non-iron supplementation in IDA patients. Conclusions Our study indicates that IDA subjects had an increased risk of psychiatric disorders, regardless of other confounders. In IDA patients, iron supplementation was associated with a decreased risk of psychiatric disorders. Moreover, IDA patients receiving iron supplementation also had a lower risk of sleep disorders. |
| first_indexed | 2024-12-13T11:46:58Z |
| format | Article |
| id | doaj.art-0a8a97a2b8304228abb738382d30b9a1 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-13T11:46:58Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-0a8a97a2b8304228abb738382d30b9a12022-12-21T23:47:28ZengBMCBMC Psychiatry1471-244X2020-05-012011910.1186/s12888-020-02621-0Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysisHerng-Sheng Lee0Hsin-Hao Chao1Wan-Ting Huang2Solomon Chih-Cheng Chen3Hsin-Yi Yang4Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General HospitalDepartment of Psychiatry, Ditmanson Medical Foundation Chia-Yi Christian HospitalClinical Medicine Research Center, Ditmanson Medical Foundation Chia-Yi Christian HospitalDepartment of Pediatrics, School of Medicine, College of Medicine, Taipei Medical UniversityClinical Medicine Research Center, Ditmanson Medical Foundation Chia-Yi Christian HospitalAbstract Background It has been shown that iron deficiency anemia (IDA) is associated with psychosocial consequences and psychiatric morbidity. However, the association between adults with IDA and psychiatric disorders has not been clarified. The purpose of this study was to investigate the psychiatric disorder morbidity of an IDA group in comparison with a non-IDA group and to examine the risk of psychiatric disorders in IDA patients treated with iron supplementation. Methods All study subjects were 20 years of age or over with newly diagnosed IDA enrolled in the Taiwan National Health Insurance Database from 2000 to 2012. We matched IDA and non-IDA subjects according to age and gender in a 1:2 ratio. Our primary outcome was diagnosis of psychiatric disorders and the patients were monitored until the end of 2013. A multivariate Cox proportional hazards regression model was used to explore the risk of psychiatric disorders in patients with IDA after adjustment for confounders, including demographic characteristics and comorbidities. Results The adjusted hazard ratios (aHRs) of psychiatric disorders was 1.52 (95% CI = 1.45–1.59) in the IDA group compared with the non-IDA group. Among the different types of psychiatric disorders, the IDA group was associated with significantly higher incidence and risks of anxiety disorders, depression, sleep disorders, and psychotic disorders (p < 0.05). Furthermore, iron supplementation in IDA subjects was associated with a significantly lower risk of psychiatric disorders compared to non-iron supplementation in IDA patients. Conclusions Our study indicates that IDA subjects had an increased risk of psychiatric disorders, regardless of other confounders. In IDA patients, iron supplementation was associated with a decreased risk of psychiatric disorders. Moreover, IDA patients receiving iron supplementation also had a lower risk of sleep disorders.http://link.springer.com/article/10.1186/s12888-020-02621-0Iron deficiency anemiaPsychiatric disordersIron supplementationGender difference |
| spellingShingle | Herng-Sheng Lee Hsin-Hao Chao Wan-Ting Huang Solomon Chih-Cheng Chen Hsin-Yi Yang Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis BMC Psychiatry Iron deficiency anemia Psychiatric disorders Iron supplementation Gender difference |
| title | Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis |
| title_full | Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis |
| title_fullStr | Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis |
| title_full_unstemmed | Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis |
| title_short | Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis |
| title_sort | psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications a nationwide database analysis |
| topic | Iron deficiency anemia Psychiatric disorders Iron supplementation Gender difference |
| url | http://link.springer.com/article/10.1186/s12888-020-02621-0 |
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