Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study.
<h4>Background</h4>Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) in the development of ICAS remains to be elucidated. In the current...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23691210/pdf/?tool=EBI |
| _version_ | 1829488225312309248 |
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| author | Yining Qian Yuehua Pu Liping Liu David Z Wang Xingquan Zhao Chunxue Wang Yilong Wang Gaifen Liu Yuesong Pan Yongjun Wang |
| author_facet | Yining Qian Yuehua Pu Liping Liu David Z Wang Xingquan Zhao Chunxue Wang Yilong Wang Gaifen Liu Yuesong Pan Yongjun Wang |
| author_sort | Yining Qian |
| collection | DOAJ |
| description | <h4>Background</h4>Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke.<h4>Methods</h4>From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA). Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888) and non-intracranial stenosis (NICAS group, n = 1096). Serum lipid profiles were analyzed and compared between the ICAS and NICAS group.<h4>Results</h4>Significantly more patients in ICAS group had low HDL-C level (51.6%) than in the NICAS group (42.9%, P<0.001). The observed association remained significant after adjustment for conventional risk factors [(adjusted OR 1.36; 95%CI (1.13-1.63)]. Such predictive value of low level HDL-C persisted even when LDL-C was at very low level(<1.8 mmol/L). Patients in the lowest serum HDL-C quartile (<0.96 mmol/L) had the highest risk of developing ICAS [adjusted OR 1.52; 95%CI (1.17-1.98)] compared to patients in the highest serum HDL-C quartile (≥ 1.32 mmol/L) after adjustments for the covariates.<h4>Conclusions</h4>Low HDL-C level is strongly associated with the development of ICAS. There was an inverse relationship between the level of HDL-C and the risk of developing ICAS. |
| first_indexed | 2024-12-14T23:46:03Z |
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| id | doaj.art-0a8b06df9e87420299df554306ae19cd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:46:03Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-0a8b06df9e87420299df554306ae19cd2022-12-21T22:43:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6439510.1371/journal.pone.0064395Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study.Yining QianYuehua PuLiping LiuDavid Z WangXingquan ZhaoChunxue WangYilong WangGaifen LiuYuesong PanYongjun Wang<h4>Background</h4>Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke.<h4>Methods</h4>From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA). Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888) and non-intracranial stenosis (NICAS group, n = 1096). Serum lipid profiles were analyzed and compared between the ICAS and NICAS group.<h4>Results</h4>Significantly more patients in ICAS group had low HDL-C level (51.6%) than in the NICAS group (42.9%, P<0.001). The observed association remained significant after adjustment for conventional risk factors [(adjusted OR 1.36; 95%CI (1.13-1.63)]. Such predictive value of low level HDL-C persisted even when LDL-C was at very low level(<1.8 mmol/L). Patients in the lowest serum HDL-C quartile (<0.96 mmol/L) had the highest risk of developing ICAS [adjusted OR 1.52; 95%CI (1.17-1.98)] compared to patients in the highest serum HDL-C quartile (≥ 1.32 mmol/L) after adjustments for the covariates.<h4>Conclusions</h4>Low HDL-C level is strongly associated with the development of ICAS. There was an inverse relationship between the level of HDL-C and the risk of developing ICAS.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23691210/pdf/?tool=EBI |
| spellingShingle | Yining Qian Yuehua Pu Liping Liu David Z Wang Xingquan Zhao Chunxue Wang Yilong Wang Gaifen Liu Yuesong Pan Yongjun Wang Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. PLoS ONE |
| title | Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. |
| title_full | Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. |
| title_fullStr | Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. |
| title_full_unstemmed | Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. |
| title_short | Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. |
| title_sort | low hdl c level is associated with the development of intracranial artery stenosis analysis from the chinese intracranial atherosclerosis cicas study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23691210/pdf/?tool=EBI |
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