Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report
Abstract Background Collecting duct carcinoma (CDC) is a rare renal tumor, originating from the distal collecting duct. CDC rarely presents as a primary tumor outside the renal system. Case presentation In this study, we report a rare case of collecting duct carcinoma, with an initial presentation o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-023-01295-6 |
| _version_ | 1827890220707610624 |
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| author | Rupei Ye Yehui Liao Tian Xia Xinfeng Zhang Qiyi Lu Xiuli Xiao |
| author_facet | Rupei Ye Yehui Liao Tian Xia Xinfeng Zhang Qiyi Lu Xiuli Xiao |
| author_sort | Rupei Ye |
| collection | DOAJ |
| description | Abstract Background Collecting duct carcinoma (CDC) is a rare renal tumor, originating from the distal collecting duct. CDC rarely presents as a primary tumor outside the renal system. Case presentation In this study, we report a rare case of collecting duct carcinoma, with an initial presentation of retroperitoneal lymph node metastasis, and no identifiable primary renal tumor on CT, at the time of diagnosis. The patient was a 64-year-old man presenting with lower back pain. Preoperative CT showed a round, soft tissue mass, measuring 6.7 × 4.4 × 3.3 cm, in the left retroperitoneum with no exact occupying lesion in the left kidney. Clinically, ectopic pheochromocytoma was considered to be a differential diagnosis, and tumor resection was performed. Postoperative pathological results demonstrated that the mass was a fused lymph node, and the tumor cells were destroying the structure. The final diagnosis was lymph node metastatic collecting duct carcinoma, by histology and immunohistochemistry. No further treatment was performed as no space occupying lesion was found in the kidney. Three months later, CT was reexamined, and a mass of 3.6 cm in diameter, was found in the lower left kidney, along with multiple soft tissue masses, in the left renal hilum. Considering recurrence or metastasis, the patient was recommended to undergo surgical treatment, but the patient refused. Four months later, CT was re-examined. The tumor had rapidly progressed but the patient refused treatment again. As per the author’s press release (eleven months after the first discovery), the patient is still alive. Conclusion CDC is a rare malignant renal carcinoma, with a high chance of rapid progress, regional lymph nodes involvement and metastasis. It presents diagnostic challenges to clinicians and pathologists, particularly, in the absence of radiographically detectable intrarenal lesions. Definite diagnosis is based on pathological examination combined with immunohistochemical staining. |
| first_indexed | 2024-03-12T21:06:34Z |
| format | Article |
| id | doaj.art-0a8b1cb862684daea8fe8444397a8ea1 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-12T21:06:34Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-0a8b1cb862684daea8fe8444397a8ea12023-07-30T11:25:30ZengBMCBMC Urology1471-24902023-07-012311610.1186/s12894-023-01295-6Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case reportRupei Ye0Yehui Liao1Tian Xia2Xinfeng Zhang3Qiyi Lu4Xiuli Xiao5Department of Pathology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Orthopaedics, The Affiliated Hospital of Southwest Medical UniversityDepartment of Pathology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Pathology, Yanyuan County People’s HospitalDepartment of Pathology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Pathology, The Affiliated Hospital of Southwest Medical UniversityAbstract Background Collecting duct carcinoma (CDC) is a rare renal tumor, originating from the distal collecting duct. CDC rarely presents as a primary tumor outside the renal system. Case presentation In this study, we report a rare case of collecting duct carcinoma, with an initial presentation of retroperitoneal lymph node metastasis, and no identifiable primary renal tumor on CT, at the time of diagnosis. The patient was a 64-year-old man presenting with lower back pain. Preoperative CT showed a round, soft tissue mass, measuring 6.7 × 4.4 × 3.3 cm, in the left retroperitoneum with no exact occupying lesion in the left kidney. Clinically, ectopic pheochromocytoma was considered to be a differential diagnosis, and tumor resection was performed. Postoperative pathological results demonstrated that the mass was a fused lymph node, and the tumor cells were destroying the structure. The final diagnosis was lymph node metastatic collecting duct carcinoma, by histology and immunohistochemistry. No further treatment was performed as no space occupying lesion was found in the kidney. Three months later, CT was reexamined, and a mass of 3.6 cm in diameter, was found in the lower left kidney, along with multiple soft tissue masses, in the left renal hilum. Considering recurrence or metastasis, the patient was recommended to undergo surgical treatment, but the patient refused. Four months later, CT was re-examined. The tumor had rapidly progressed but the patient refused treatment again. As per the author’s press release (eleven months after the first discovery), the patient is still alive. Conclusion CDC is a rare malignant renal carcinoma, with a high chance of rapid progress, regional lymph nodes involvement and metastasis. It presents diagnostic challenges to clinicians and pathologists, particularly, in the absence of radiographically detectable intrarenal lesions. Definite diagnosis is based on pathological examination combined with immunohistochemical staining.https://doi.org/10.1186/s12894-023-01295-6Collecting duct carcinomaLymph node metastasisCase report |
| spellingShingle | Rupei Ye Yehui Liao Tian Xia Xinfeng Zhang Qiyi Lu Xiuli Xiao Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report BMC Urology Collecting duct carcinoma Lymph node metastasis Case report |
| title | Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report |
| title_full | Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report |
| title_fullStr | Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report |
| title_full_unstemmed | Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report |
| title_short | Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report |
| title_sort | collecting duct carcinoma with retroperitoneal mass as initial presentation a rare case report |
| topic | Collecting duct carcinoma Lymph node metastasis Case report |
| url | https://doi.org/10.1186/s12894-023-01295-6 |
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