Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

The α-pore-forming toxins (α-PFTs) from pathogenic bacteria damage host cell membranes by pore formation. We demonstrate a remarkable, hitherto unknown mechanism by an α-PFT protein from Vibrio cholerae. As part of the MakA/B/E tripartite toxin, MakA is involved in membrane pore formation similar to...

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Bibliographic Details
Main Authors: Aftab Nadeem, Alexandra Berg, Hudson Pace, Athar Alam, Eric Toh, Jörgen Ådén, Nikola Zlatkov, Si Lhyam Myint, Karina Persson, Gerhard Gröbner, Anders Sjöstedt, Marta Bally, Jonas Barandun, Bernt Eric Uhlin, Sun Nyunt Wai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
Vibrio cholerae
MakA
lipid
Online Access:https://elifesciences.org/articles/73439

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