CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION
<p>Aim. To study the endothelium status and determine the correlation between endothelial dysfunction and glucose metabolism in men with gout associated with arterial hypertension (HT).<br />Material and methods. Patients (n=175, all are males) with gout were enrolled into the study. Amb...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | http://www.rpcardio.ru/jour/article/view/201 |
| _version_ | 1797712917792030720 |
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| author | N. N. Kushnarenko A. V. Govorin |
| author_facet | N. N. Kushnarenko A. V. Govorin |
| author_sort | N. N. Kushnarenko |
| collection | DOAJ |
| description | <p>Aim. To study the endothelium status and determine the correlation between endothelial dysfunction and glucose metabolism in men with gout associated with arterial hypertension (HT).<br />Material and methods. Patients (n=175, all are males) with gout were enrolled into the study. Ambulatory blood pressure monitoring (ABPM) was performed in all patients. Endothelial function was studied in tests with reactive hyperemia (endothelium-dependent reaction) and nitroglycerin (endothelium independent reaction) in brachial artery by ultrasonic Doppler examination. The level of nitrite-nitrate and endothelin-1 in blood serum was determined by ELISA technique. Fasting blood glucose and oral glucose tolerance tests were performed as well as fasting insulin blood level was determined by immunoenzyme method. Insulin-resistance index (HOMA-IR) was calculated. Patients with HOMA- IR>2.77 were considered as insulin-resistant.<br />Results. Patients with gout demonstrated endothelial deterioration associated with activation of nitroxid producing function, elevation in endothelin-1 serum level (1.36 fmol/ml [0.91; 2.32 fmol/ml] vs 0.19 fmol/ml [0.16; 0.27 fmol/ml] in controls, p<0.05) and impairments of endothelium-dependent vasodilation (6.4% [3.3; 7.3%] vs 17.8% [12.7; 23.9%] in controls, p<0.05). The revealed changes were the most marked in patients with gout associated with HT. The correlation between some endothelial dysfunction in- dices and glucose metabolism was observed.<br />Conclusion. ABPM, brachial artery endothelium-dependent vasodilation and glucose metabolism status should be studied in patients with gout. Complex treatment of cardiovascular diseases in patients with gout should include ω-3 polyunsaturated fatty acids, angiotensin receptor antagonists should be used for antihypertensive therapy.</p> |
| first_indexed | 2024-03-12T07:28:50Z |
| format | Article |
| id | doaj.art-0a90a14b25c3488eb91ee2c6daf08b21 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T07:28:50Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-0a90a14b25c3488eb91ee2c6daf08b212023-09-02T21:56:56ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-019548248710.1234/1819-6446-2013-5-482-487201CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSIONN. N. Kushnarenko0A. V. Govorin1Читинская государственная медицинская академия, ЧитаЧитинская государственная медицинская академия, Чита<p>Aim. To study the endothelium status and determine the correlation between endothelial dysfunction and glucose metabolism in men with gout associated with arterial hypertension (HT).<br />Material and methods. Patients (n=175, all are males) with gout were enrolled into the study. Ambulatory blood pressure monitoring (ABPM) was performed in all patients. Endothelial function was studied in tests with reactive hyperemia (endothelium-dependent reaction) and nitroglycerin (endothelium independent reaction) in brachial artery by ultrasonic Doppler examination. The level of nitrite-nitrate and endothelin-1 in blood serum was determined by ELISA technique. Fasting blood glucose and oral glucose tolerance tests were performed as well as fasting insulin blood level was determined by immunoenzyme method. Insulin-resistance index (HOMA-IR) was calculated. Patients with HOMA- IR>2.77 were considered as insulin-resistant.<br />Results. Patients with gout demonstrated endothelial deterioration associated with activation of nitroxid producing function, elevation in endothelin-1 serum level (1.36 fmol/ml [0.91; 2.32 fmol/ml] vs 0.19 fmol/ml [0.16; 0.27 fmol/ml] in controls, p<0.05) and impairments of endothelium-dependent vasodilation (6.4% [3.3; 7.3%] vs 17.8% [12.7; 23.9%] in controls, p<0.05). The revealed changes were the most marked in patients with gout associated with HT. The correlation between some endothelial dysfunction in- dices and glucose metabolism was observed.<br />Conclusion. ABPM, brachial artery endothelium-dependent vasodilation and glucose metabolism status should be studied in patients with gout. Complex treatment of cardiovascular diseases in patients with gout should include ω-3 polyunsaturated fatty acids, angiotensin receptor antagonists should be used for antihypertensive therapy.</p>http://www.rpcardio.ru/jour/article/view/201подаграартериальная гипертензияэндотелиальная дисфункциянитроксидпродуцирующая функцияэндотелин-1инсулинорезистентность |
| spellingShingle | N. N. Kushnarenko A. V. Govorin CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION Рациональная фармакотерапия в кардиологии подагра артериальная гипертензия эндотелиальная дисфункция нитроксидпродуцирующая функция эндотелин-1 инсулинорезистентность |
| title | CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION |
| title_full | CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION |
| title_fullStr | CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION |
| title_full_unstemmed | CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION |
| title_short | CLINICAL IMPORTANCE OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE SYNDROME IN PATIENTS WITH GOUT ASSOCIATED WITH ARTERIAL HYPERTENSION |
| title_sort | clinical importance of endothelial dysfunction and insulin resistance syndrome in patients with gout associated with arterial hypertension |
| topic | подагра артериальная гипертензия эндотелиальная дисфункция нитроксидпродуцирующая функция эндотелин-1 инсулинорезистентность |
| url | http://www.rpcardio.ru/jour/article/view/201 |
| work_keys_str_mv | AT nnkushnarenko clinicalimportanceofendothelialdysfunctionandinsulinresistancesyndromeinpatientswithgoutassociatedwitharterialhypertension AT avgovorin clinicalimportanceofendothelialdysfunctionandinsulinresistancesyndromeinpatientswithgoutassociatedwitharterialhypertension |