Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis
Abstract Background Endometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is uncl...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01280-7 |
| _version_ | 1797453453598916608 |
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| author | Jian-Peng Chen Yan-Ye Zhang Jia-Ni Jin Yue Ying Zhi-Min Song Qi-Qi Xu Mi-Xue Tu Xiao-Hang Ye Huan-Na Tang Fei-Da Ni Yan-Yun Ying Jing-Yi Li Dan Zhang |
| author_facet | Jian-Peng Chen Yan-Ye Zhang Jia-Ni Jin Yue Ying Zhi-Min Song Qi-Qi Xu Mi-Xue Tu Xiao-Hang Ye Huan-Na Tang Fei-Da Ni Yan-Yun Ying Jing-Yi Li Dan Zhang |
| author_sort | Jian-Peng Chen |
| collection | DOAJ |
| description | Abstract Background Endometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is unclear. We aimed to evaluate the characteristics of systemic metabolic indexes of endometriosis patients with infertility and their effects on pregnancy outcome after ART treatment. Methods A retrospective cohort study involve 412 endometriosis patients and 1551 controls was conducted. Primary outcome was metabolic indexes, and secondary measures consisted of the influence of metabolic indexes on the number of retrieved oocytes and ART outcomes. Results Endometriosis patients had higher insulin (INS) [6.90(5.10–9.50) vs 6.50(4.80–8.90) μU/mL, P = 0.005]. A prediction model for endometriosis combining the number of previous pregnancies, CA125, fasting blood glucose (Glu) and INS, had a sensitivity of 73.9%, specificity of 67.8% and area under curve (AUC) of 0.77. There were no significant differences in ART outcomes and complications during pregnancy. The serum levels of Glu before pregnancy were associated with GDM both in endometriosis group (aOR 12.95, 95% CI 1.69–99.42, P = 0.014) and in control group (aOR 4.15, 95% CI 1.50–11.53, P = 0.006). Conclusions We found serum Glu is related to the number of retrieved oocytes in control group, serum INS is related to the number of retrieved oocytes in endometriosis group, while serum Glu and INS before pregnancy are related to the occurrence of GDM in two groups. A prediction model based on metabolic indexes was established, representing a promising non-invasive method to predict endometriosis patients with known pregnancy history. |
| first_indexed | 2024-03-09T15:22:04Z |
| format | Article |
| id | doaj.art-0a92d50d32184740b2c634995bc0c6f4 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T15:22:04Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-0a92d50d32184740b2c634995bc0c6f42023-11-26T12:42:11ZengBMCEuropean Journal of Medical Research2047-783X2023-08-0128111110.1186/s40001-023-01280-7Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosisJian-Peng Chen0Yan-Ye Zhang1Jia-Ni Jin2Yue Ying3Zhi-Min Song4Qi-Qi Xu5Mi-Xue Tu6Xiao-Hang Ye7Huan-Na Tang8Fei-Da Ni9Yan-Yun Ying10Jing-Yi Li11Dan Zhang12Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of MedicineAbstract Background Endometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is unclear. We aimed to evaluate the characteristics of systemic metabolic indexes of endometriosis patients with infertility and their effects on pregnancy outcome after ART treatment. Methods A retrospective cohort study involve 412 endometriosis patients and 1551 controls was conducted. Primary outcome was metabolic indexes, and secondary measures consisted of the influence of metabolic indexes on the number of retrieved oocytes and ART outcomes. Results Endometriosis patients had higher insulin (INS) [6.90(5.10–9.50) vs 6.50(4.80–8.90) μU/mL, P = 0.005]. A prediction model for endometriosis combining the number of previous pregnancies, CA125, fasting blood glucose (Glu) and INS, had a sensitivity of 73.9%, specificity of 67.8% and area under curve (AUC) of 0.77. There were no significant differences in ART outcomes and complications during pregnancy. The serum levels of Glu before pregnancy were associated with GDM both in endometriosis group (aOR 12.95, 95% CI 1.69–99.42, P = 0.014) and in control group (aOR 4.15, 95% CI 1.50–11.53, P = 0.006). Conclusions We found serum Glu is related to the number of retrieved oocytes in control group, serum INS is related to the number of retrieved oocytes in endometriosis group, while serum Glu and INS before pregnancy are related to the occurrence of GDM in two groups. A prediction model based on metabolic indexes was established, representing a promising non-invasive method to predict endometriosis patients with known pregnancy history.https://doi.org/10.1186/s40001-023-01280-7EndometriosisMetabolic indicatorNumber of retrieved oocytesART outcomesGDM |
| spellingShingle | Jian-Peng Chen Yan-Ye Zhang Jia-Ni Jin Yue Ying Zhi-Min Song Qi-Qi Xu Mi-Xue Tu Xiao-Hang Ye Huan-Na Tang Fei-Da Ni Yan-Yun Ying Jing-Yi Li Dan Zhang Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis European Journal of Medical Research Endometriosis Metabolic indicator Number of retrieved oocytes ART outcomes GDM |
| title | Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis |
| title_full | Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis |
| title_fullStr | Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis |
| title_full_unstemmed | Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis |
| title_short | Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis |
| title_sort | effects of dysregulated glucose metabolism on the occurrence and art outcome of endometriosis |
| topic | Endometriosis Metabolic indicator Number of retrieved oocytes ART outcomes GDM |
| url | https://doi.org/10.1186/s40001-023-01280-7 |
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