Diabetic endothelial microangiopathy and pulmonary dysfunction
Type 2 diabetes mellitus (T2DM) is a widespread metabolic condition with a high global morbidity and mortality rate that affects the whole body. Their primary consequences are mostly caused by the macrovascular and microvascular bed degradation brought on by metabolic, hemodynamic, and inflammatory...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1073878/full |
| _version_ | 1827986374011125760 |
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| author | Lanlan Zhang Faming Jiang Yingying Xie Yan Mo Xin Zhang Chuntao Liu |
| author_facet | Lanlan Zhang Faming Jiang Yingying Xie Yan Mo Xin Zhang Chuntao Liu |
| author_sort | Lanlan Zhang |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is a widespread metabolic condition with a high global morbidity and mortality rate that affects the whole body. Their primary consequences are mostly caused by the macrovascular and microvascular bed degradation brought on by metabolic, hemodynamic, and inflammatory variables. However, research in recent years has expanded the target organ in T2DM to include the lung. Inflammatory lung diseases also impose a severe financial burden on global healthcare. T2DM has long been recognized as a significant comorbidity that influences the course of various respiratory disorders and their disease progress. The pathogenesis of the glycemic metabolic problem and endothelial microangiopathy of the respiratory disorders have garnered more attention lately, indicating that the two ailments have a shared history. This review aims to outline the connection between T2DM related endothelial cell dysfunction and concomitant respiratory diseases, including Coronavirus disease 2019 (COVID-19), asthma, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). |
| first_indexed | 2024-04-09T23:29:17Z |
| format | Article |
| id | doaj.art-0a93035b214946018230cbea0f41f492 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T23:29:17Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0a93035b214946018230cbea0f41f4922023-03-21T06:02:21ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.10738781073878Diabetic endothelial microangiopathy and pulmonary dysfunctionLanlan Zhang0Faming Jiang1Yingying Xie2Yan Mo3Xin Zhang4Chuntao Liu5Department of Respiratory and Critical Care Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Nephrology, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Neurology Medicine, The Aviation Industry Corporation of China (AVIC) 363 Hospital, Chengdu, ChinaDepartment of Gastroenterology, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Respiratory and Critical Care Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaType 2 diabetes mellitus (T2DM) is a widespread metabolic condition with a high global morbidity and mortality rate that affects the whole body. Their primary consequences are mostly caused by the macrovascular and microvascular bed degradation brought on by metabolic, hemodynamic, and inflammatory variables. However, research in recent years has expanded the target organ in T2DM to include the lung. Inflammatory lung diseases also impose a severe financial burden on global healthcare. T2DM has long been recognized as a significant comorbidity that influences the course of various respiratory disorders and their disease progress. The pathogenesis of the glycemic metabolic problem and endothelial microangiopathy of the respiratory disorders have garnered more attention lately, indicating that the two ailments have a shared history. This review aims to outline the connection between T2DM related endothelial cell dysfunction and concomitant respiratory diseases, including Coronavirus disease 2019 (COVID-19), asthma, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).https://www.frontiersin.org/articles/10.3389/fendo.2023.1073878/fullendothelial cellsCOVID-19asthmaCOPDtype-2 diabetes |
| spellingShingle | Lanlan Zhang Faming Jiang Yingying Xie Yan Mo Xin Zhang Chuntao Liu Diabetic endothelial microangiopathy and pulmonary dysfunction Frontiers in Endocrinology endothelial cells COVID-19 asthma COPD type-2 diabetes |
| title | Diabetic endothelial microangiopathy and pulmonary dysfunction |
| title_full | Diabetic endothelial microangiopathy and pulmonary dysfunction |
| title_fullStr | Diabetic endothelial microangiopathy and pulmonary dysfunction |
| title_full_unstemmed | Diabetic endothelial microangiopathy and pulmonary dysfunction |
| title_short | Diabetic endothelial microangiopathy and pulmonary dysfunction |
| title_sort | diabetic endothelial microangiopathy and pulmonary dysfunction |
| topic | endothelial cells COVID-19 asthma COPD type-2 diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1073878/full |
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