Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2

Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatin-binding protein involved in neuronal development and maturation. Loss-of-function mutations in MeCP2 result in Rett syndrome (RTT), a neurodevelopmental disorder that is the main cause of mental retardation in female...

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Bibliographic Details
Main Authors: David Ortega-Alarcon, Rafael Claveria-Gimeno, Sonia Vega, Olga C. Jorge-Torres, Manel Esteller, Olga Abian, Adrian Velazquez-Campoy
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
Methyl-CpG-binding protein 2 (MeCP2)
Rett syndrome
intrinsically disordered protein (IDP)
protein stability
protein-DNA interaction
isothermal titration calorimetry (ITC)
Online Access:https://www.mdpi.com/2218-273X/10/11/1533

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