Multiple Myeloma in a Patient with Acromegaly
Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2015-03-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-110.pdf |
| _version_ | 1811331564329500672 |
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| author | Yu Mi Kang Jong Han Choi Min Jung Lee Ari Ahn Chan-Jeoung Park Kiju Chang Seyoung Seo Sun In Hong Min-Seon Kim |
| author_facet | Yu Mi Kang Jong Han Choi Min Jung Lee Ari Ahn Chan-Jeoung Park Kiju Chang Seyoung Seo Sun In Hong Min-Seon Kim |
| author_sort | Yu Mi Kang |
| collection | DOAJ |
| description | Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation by increasing cell proliferation and inhibiting apoptosis. Multiple myeloma (MM) is a plasma cell neoplasm, and previous studies have suggested the possible role of IGF-1 in its development of MM. However, no cases of acromegaly accompanied with MM have been reported in Asia to date. We here report the case of a 58-year-old woman with acromegaly accompanied with MM who presented with longstanding acromegalic manifestations resulting from a GH-secreting pituitary adenoma and also exhibited anemia, a reversed albumin/globulin ratio, and plasmacytosis on bone marrow examination. Because IGF-1 has been suggested to play an important role in the development and progression of MM, the patient promptly underwent surgical removal of the pituitary adenoma via a transsphenoidal approach. Since there is currently no consensus on therapeutic guidelines and suggested prognosis for MM with acromegaly, long-term follow-up of such cases is needed. |
| first_indexed | 2024-04-13T16:22:32Z |
| format | Article |
| id | doaj.art-0a95a8eb87af449eaf76210689d439c0 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T16:22:32Z |
| publishDate | 2015-03-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-0a95a8eb87af449eaf76210689d439c02022-12-22T02:39:51ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-03-0130111011510.3803/EnM.2015.30.1.11020791Multiple Myeloma in a Patient with AcromegalyYu Mi KangJong Han ChoiMin Jung LeeAri AhnChan-Jeoung ParkKiju ChangSeyoung SeoSun In HongMin-Seon KimAcromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation by increasing cell proliferation and inhibiting apoptosis. Multiple myeloma (MM) is a plasma cell neoplasm, and previous studies have suggested the possible role of IGF-1 in its development of MM. However, no cases of acromegaly accompanied with MM have been reported in Asia to date. We here report the case of a 58-year-old woman with acromegaly accompanied with MM who presented with longstanding acromegalic manifestations resulting from a GH-secreting pituitary adenoma and also exhibited anemia, a reversed albumin/globulin ratio, and plasmacytosis on bone marrow examination. Because IGF-1 has been suggested to play an important role in the development and progression of MM, the patient promptly underwent surgical removal of the pituitary adenoma via a transsphenoidal approach. Since there is currently no consensus on therapeutic guidelines and suggested prognosis for MM with acromegaly, long-term follow-up of such cases is needed.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-110.pdfAcromegalyMultiple myelomaInsulin-like growth factor I |
| spellingShingle | Yu Mi Kang Jong Han Choi Min Jung Lee Ari Ahn Chan-Jeoung Park Kiju Chang Seyoung Seo Sun In Hong Min-Seon Kim Multiple Myeloma in a Patient with Acromegaly Endocrinology and Metabolism Acromegaly Multiple myeloma Insulin-like growth factor I |
| title | Multiple Myeloma in a Patient with Acromegaly |
| title_full | Multiple Myeloma in a Patient with Acromegaly |
| title_fullStr | Multiple Myeloma in a Patient with Acromegaly |
| title_full_unstemmed | Multiple Myeloma in a Patient with Acromegaly |
| title_short | Multiple Myeloma in a Patient with Acromegaly |
| title_sort | multiple myeloma in a patient with acromegaly |
| topic | Acromegaly Multiple myeloma Insulin-like growth factor I |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-110.pdf |
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