Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients

Back ground: A lot of previous researches studded the endoneural microangiopathy and small vessels diabetic pathological change, but little studded about the diabetic angiopathy of the larger vessels like popliteal artery and related diabetic risk factors .Accordingly the present work designed to s...

Full description

Bibliographic Details
Main Authors: Payman Jamal Muhamad Ameen, Talib Jawad Kazim, Hewa Baker
Format: Article
Language:English
Published: College of medicine/ University of Diyala 2019-12-01
Series:Diyala Journal of Medicine
Subjects:
Online Access:https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/348
_version_ 1827717554392530944
author Payman Jamal Muhamad Ameen
Talib Jawad Kazim
Hewa Baker
author_facet Payman Jamal Muhamad Ameen
Talib Jawad Kazim
Hewa Baker
author_sort Payman Jamal Muhamad Ameen
collection DOAJ
description Back ground: A lot of previous researches studded the endoneural microangiopathy and small vessels diabetic pathological change, but little studded about the diabetic angiopathy of the larger vessels like popliteal artery and related diabetic risk factors .Accordingly the present work designed to study the structural and histochemical changes of the popliteal artery as one of the medium size vessels. Objective: Evaluation of the histopathological and histochemical measurement, of the popliteal artery in diabetic male and female patients with different duration of the diseases, in comparison with normal non diabetic samples.  Patient and methods: Histological sections, taken from amputated legs of 30 diabetic patients (8 females and 22 males) at age of (55-75) years, and 30 cadavers (4 females and 26 males) at age of (25-50) years as control group. Results: Histological sections from the popliteal artery of diabetic patients, showed marked decrease in the diameter of the lumen, reduced thickness of tunica media and adventitia, but increase in the thickness of tunica intimae and basement membrane. The loss of endothelium in some places, cellular infiltrations in tunica media with Periodic Acid Schiff positive particles, and in more advance cases calcifications, and organized thrombus was also detected. The multiple regression analysis, showed significant effect of duration of diabetes on the diameter of the lumen, and thickness of the wall and the tunica intima and media of the popliteal artery. Recommendation: Great vessels of diabetic patients, recommended to be examined by the available imaging technique.
first_indexed 2024-03-10T20:04:07Z
format Article
id doaj.art-0a969143e5fe42d7a3c8a39a2d813ff4
institution Directory Open Access Journal
issn 2219-9764
2617-8982
language English
last_indexed 2024-03-10T20:04:07Z
publishDate 2019-12-01
publisher College of medicine/ University of Diyala
record_format Article
series Diyala Journal of Medicine
spelling doaj.art-0a969143e5fe42d7a3c8a39a2d813ff42023-11-19T23:20:23ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-12-0171Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients Payman Jamal Muhamad Ameen Talib Jawad Kazim Hewa Baker Back ground: A lot of previous researches studded the endoneural microangiopathy and small vessels diabetic pathological change, but little studded about the diabetic angiopathy of the larger vessels like popliteal artery and related diabetic risk factors .Accordingly the present work designed to study the structural and histochemical changes of the popliteal artery as one of the medium size vessels. Objective: Evaluation of the histopathological and histochemical measurement, of the popliteal artery in diabetic male and female patients with different duration of the diseases, in comparison with normal non diabetic samples.  Patient and methods: Histological sections, taken from amputated legs of 30 diabetic patients (8 females and 22 males) at age of (55-75) years, and 30 cadavers (4 females and 26 males) at age of (25-50) years as control group. Results: Histological sections from the popliteal artery of diabetic patients, showed marked decrease in the diameter of the lumen, reduced thickness of tunica media and adventitia, but increase in the thickness of tunica intimae and basement membrane. The loss of endothelium in some places, cellular infiltrations in tunica media with Periodic Acid Schiff positive particles, and in more advance cases calcifications, and organized thrombus was also detected. The multiple regression analysis, showed significant effect of duration of diabetes on the diameter of the lumen, and thickness of the wall and the tunica intima and media of the popliteal artery. Recommendation: Great vessels of diabetic patients, recommended to be examined by the available imaging technique. https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/348Histopathological , Histochemical
spellingShingle Payman Jamal Muhamad Ameen
Talib Jawad Kazim
Hewa Baker
Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients
Diyala Journal of Medicine
Histopathological , Histochemical
title Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients
title_full Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients
title_fullStr Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients
title_full_unstemmed Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients
title_short Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients
title_sort histopathological and histochemical changes of the popliteal artery in diabetic patients
topic Histopathological , Histochemical
url https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/348
work_keys_str_mv AT paymanjamalmuhamadameen histopathologicalandhistochemicalchangesofthepoplitealarteryindiabeticpatients
AT talibjawadkazim histopathologicalandhistochemicalchangesofthepoplitealarteryindiabeticpatients
AT hewabaker histopathologicalandhistochemicalchangesofthepoplitealarteryindiabeticpatients