Exposure of Human Lung Cancer Cells to 8-Chloro-Adenosine Induces G2/M Arrest and Mitotic Catastrophe

Exposure of Human Lung Cancer Cells to 8-Chloro-Adenosine Induces G2/M Arrest and Mitotic Catastrophe

8-Chloro-adenosine (8-CI-Ado) is a potent chemotherapeutic agent whose cytotoxicity in a variety of tumor cell lines has been widely investigated. However, the molecular mechanisms are uncertain. In this study, we found that exposure of human lung cancer cell lines A549 (p53-wt) and H1299 (p53-deple...

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Bibliographic Details
Main Authors: Hong-Yu Zhang, Yan-Yan Gu, Zeng-Gang Li, Yu-Hong Jia, Lan Yuan, Shu-Yan Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Jia
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
8-chloro-adenosine
cytotoxicity
G2/M arrest
mitotic catastrophe
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800137

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