DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through...

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Bibliographic Details
Main Authors: Stephanie J Papp, Anne-Laure Huber, Sabine D Jordan, Anna Kriebs, Madelena Nguyen, James J Moresco, John R Yates III, Katja A Lamia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
circadian rhythm
cryptochrome
Hausp
DNA damage
ubiquitin
phosphorylation
Online Access:https://elifesciences.org/articles/04883

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