How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Bone marrow-derived mast cells (BMMCs) are often used as a model system for studies of the role of MCs in health and disease. These cells are relatively easy to obtain from total bone marrow cells by culturing under the influence of IL-3 or stem cell factor (SCF). After 3 to 4 weeks in culture, a ne...

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Bibliographic Details
Main Authors: Srinivas Akula, Aida Paivandy, Zhirong Fu, Michael Thorpe, Gunnar Pejler, Lars Hellman
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
in vitro model
transcriptome
mRNA
mast cell
tryptase
chymase
Online Access:https://www.mdpi.com/2073-4409/9/9/2118

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