The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients
Objective cognitive dysfunction has been commonly found in patients with insomnia, such as attention, memory, speed of information processing, and executive functions. Auditory steady-state responses (ASSRs), P50, mismatch negativity (MMN) can meet varied need and estimate such different cognitive d...
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| Format: | Article |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.714302/full |
| _version_ | 1818690764845088768 |
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| author | Hongwei Zhao Chang Liu Changming Wang Xiangyu Zheng Yanhui Peng Yudan Lv |
| author_facet | Hongwei Zhao Chang Liu Changming Wang Xiangyu Zheng Yanhui Peng Yudan Lv |
| author_sort | Hongwei Zhao |
| collection | DOAJ |
| description | Objective cognitive dysfunction has been commonly found in patients with insomnia, such as attention, memory, speed of information processing, and executive functions. Auditory steady-state responses (ASSRs), P50, mismatch negativity (MMN) can meet varied need and estimate such different cognitive dysfunction. Thus, we can examine whether insomnia is associated with different cognitive dysfunction by such multiple event-related potential (ERP) tasks. Methods we used polysomnography (PSG) to record such objective PSG parameters. ASSR, P50, and MMN were performed in sequence, different ERP components have been analyzed such as latency or amplitude between insomnia group and control group. And we chosed person correlation to make correlation analysis between different ERP components and gender, education, and sleep characteristics. Results there is a significant gender difference of ASSR latency found in insomnia group, and the similar result has been found in suppression ratio of amplitudes (S2:S1) for P50. Additionally, a significant correlation between sleep characteristics and ASSR, P50 has been found. Furthermore, there was a significant difference of MMN latency between insomnia and control group, and between sleep characteristics and varied MMN parameters as latency and amplitude. Discussion our results suggested robust electrophysiological abnormalities as ASSR, P50, and MMN in insomnia patients. Such abnormalities included gender difference, education difference, difference in depressive tendency, and difference in sleep parameters. That results revealed varied cognitive dysfunction involving inputs and processing in insomnia patients. And at the same time, we have also explored the neuropsychological mechanisms underlying the cognitive dysfunction with such different ERP tasks. |
| first_indexed | 2024-12-17T12:31:11Z |
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| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-17T12:31:11Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-0a9c0fb007e041ab926038202296d5d82022-12-21T21:48:32ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-09-011510.3389/fnhum.2021.714302714302The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia PatientsHongwei Zhao0Chang Liu1Changming Wang2Xiangyu Zheng3Yanhui Peng4Yudan Lv5Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaObjective cognitive dysfunction has been commonly found in patients with insomnia, such as attention, memory, speed of information processing, and executive functions. Auditory steady-state responses (ASSRs), P50, mismatch negativity (MMN) can meet varied need and estimate such different cognitive dysfunction. Thus, we can examine whether insomnia is associated with different cognitive dysfunction by such multiple event-related potential (ERP) tasks. Methods we used polysomnography (PSG) to record such objective PSG parameters. ASSR, P50, and MMN were performed in sequence, different ERP components have been analyzed such as latency or amplitude between insomnia group and control group. And we chosed person correlation to make correlation analysis between different ERP components and gender, education, and sleep characteristics. Results there is a significant gender difference of ASSR latency found in insomnia group, and the similar result has been found in suppression ratio of amplitudes (S2:S1) for P50. Additionally, a significant correlation between sleep characteristics and ASSR, P50 has been found. Furthermore, there was a significant difference of MMN latency between insomnia and control group, and between sleep characteristics and varied MMN parameters as latency and amplitude. Discussion our results suggested robust electrophysiological abnormalities as ASSR, P50, and MMN in insomnia patients. Such abnormalities included gender difference, education difference, difference in depressive tendency, and difference in sleep parameters. That results revealed varied cognitive dysfunction involving inputs and processing in insomnia patients. And at the same time, we have also explored the neuropsychological mechanisms underlying the cognitive dysfunction with such different ERP tasks.https://www.frontiersin.org/articles/10.3389/fnhum.2021.714302/fullinsomniacognitive dysfunctionASSRsP50MMN |
| spellingShingle | Hongwei Zhao Chang Liu Changming Wang Xiangyu Zheng Yanhui Peng Yudan Lv The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients Frontiers in Human Neuroscience insomnia cognitive dysfunction ASSRs P50 MMN |
| title | The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients |
| title_full | The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients |
| title_fullStr | The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients |
| title_full_unstemmed | The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients |
| title_short | The Application of ASSRs, P50, and MMN in the Exploration of Cognitive Dysfunction Involving Inputs and Processing in Insomnia Patients |
| title_sort | application of assrs p50 and mmn in the exploration of cognitive dysfunction involving inputs and processing in insomnia patients |
| topic | insomnia cognitive dysfunction ASSRs P50 MMN |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.714302/full |
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