Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study
The use of antibiotics following oral poisoning by corrosives and organophosphates is controversial. We assessed the clinical outcomes of using antibiotics in acute poisonous ingestion involving corrosives or organophosphates by conducting a retrospective cohort study of patients presenting to the e...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/11/4/300 |
| _version_ | 1797603335801405440 |
|---|---|
| author | Joud K. Altuwaijri Fatma M. Hamiduddin Raghad H. Khafaji Leyan T. Almaghrabi Hussain T. Bakhsh Abrar K. Thabit |
| author_facet | Joud K. Altuwaijri Fatma M. Hamiduddin Raghad H. Khafaji Leyan T. Almaghrabi Hussain T. Bakhsh Abrar K. Thabit |
| author_sort | Joud K. Altuwaijri |
| collection | DOAJ |
| description | The use of antibiotics following oral poisoning by corrosives and organophosphates is controversial. We assessed the clinical outcomes of using antibiotics in acute poisonous ingestion involving corrosives or organophosphates by conducting a retrospective cohort study of patients presenting to the emergency department following ingestion of corrosives or organophosphates who received either antibiotics or supportive care. The endpoints included clinical stability, length of stay (LOS), and mortality. Of 95 patients, 40 received antibiotics and 55 received supportive care. The median age was 2.1 and 2.7 years, respectively (<i>p</i> = 0.053). Bacterial growth was shown in only 2 of 28 cultures (both were respiratory), but with hospital-acquired organisms as it was shown ≥4 days post-admission. Clinical stability rates were 60% and 89.1% in the antibiotic and supportive care groups, respectively (<i>p</i> < 0.001). Median LOS was 3 vs. 0 days (<i>p</i> < 0.001), and no mortality was recorded. NG/G-tube placement was the only factor associated with clinical failure (OR, 20.97; 95% CI, 2.36–186.13). Antibiotic use was not associated with higher chances of clinical stability, which may suggest that their use was unnecessary. Clinicians are encouraged to use antibiotics wisely, and only in the presence of a clear indication of an infection. This study provides a basis for future prospective studies to confirm its findings. |
| first_indexed | 2024-03-11T04:27:44Z |
| format | Article |
| id | doaj.art-0a9c4c1a6fc4499c8be95be377bd8125 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T04:27:44Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-0a9c4c1a6fc4499c8be95be377bd81252023-11-17T21:36:54ZengMDPI AGToxics2305-63042023-03-0111430010.3390/toxics11040300Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort StudyJoud K. Altuwaijri0Fatma M. Hamiduddin1Raghad H. Khafaji2Leyan T. Almaghrabi3Hussain T. Bakhsh4Abrar K. Thabit5Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi ArabiaFaculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi ArabiaFaculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi ArabiaFaculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi ArabiaPharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi ArabiaPharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi ArabiaThe use of antibiotics following oral poisoning by corrosives and organophosphates is controversial. We assessed the clinical outcomes of using antibiotics in acute poisonous ingestion involving corrosives or organophosphates by conducting a retrospective cohort study of patients presenting to the emergency department following ingestion of corrosives or organophosphates who received either antibiotics or supportive care. The endpoints included clinical stability, length of stay (LOS), and mortality. Of 95 patients, 40 received antibiotics and 55 received supportive care. The median age was 2.1 and 2.7 years, respectively (<i>p</i> = 0.053). Bacterial growth was shown in only 2 of 28 cultures (both were respiratory), but with hospital-acquired organisms as it was shown ≥4 days post-admission. Clinical stability rates were 60% and 89.1% in the antibiotic and supportive care groups, respectively (<i>p</i> < 0.001). Median LOS was 3 vs. 0 days (<i>p</i> < 0.001), and no mortality was recorded. NG/G-tube placement was the only factor associated with clinical failure (OR, 20.97; 95% CI, 2.36–186.13). Antibiotic use was not associated with higher chances of clinical stability, which may suggest that their use was unnecessary. Clinicians are encouraged to use antibiotics wisely, and only in the presence of a clear indication of an infection. This study provides a basis for future prospective studies to confirm its findings.https://www.mdpi.com/2305-6304/11/4/300antibioticscorrosiveorganophosphatespoisoningtoxicityingestion |
| spellingShingle | Joud K. Altuwaijri Fatma M. Hamiduddin Raghad H. Khafaji Leyan T. Almaghrabi Hussain T. Bakhsh Abrar K. Thabit Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study Toxics antibiotics corrosive organophosphates poisoning toxicity ingestion |
| title | Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study |
| title_full | Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study |
| title_fullStr | Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study |
| title_full_unstemmed | Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study |
| title_short | Use of Antibiotics in Poisonous Ingestions of Corrosives and Organophosphates: A Retrospective Cohort Study |
| title_sort | use of antibiotics in poisonous ingestions of corrosives and organophosphates a retrospective cohort study |
| topic | antibiotics corrosive organophosphates poisoning toxicity ingestion |
| url | https://www.mdpi.com/2305-6304/11/4/300 |
| work_keys_str_mv | AT joudkaltuwaijri useofantibioticsinpoisonousingestionsofcorrosivesandorganophosphatesaretrospectivecohortstudy AT fatmamhamiduddin useofantibioticsinpoisonousingestionsofcorrosivesandorganophosphatesaretrospectivecohortstudy AT raghadhkhafaji useofantibioticsinpoisonousingestionsofcorrosivesandorganophosphatesaretrospectivecohortstudy AT leyantalmaghrabi useofantibioticsinpoisonousingestionsofcorrosivesandorganophosphatesaretrospectivecohortstudy AT hussaintbakhsh useofantibioticsinpoisonousingestionsofcorrosivesandorganophosphatesaretrospectivecohortstudy AT abrarkthabit useofantibioticsinpoisonousingestionsofcorrosivesandorganophosphatesaretrospectivecohortstudy |