Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure
Fundamental gaps remain in our understanding of how immunity to malaria develops. We used detailed clinical and entomological data from parallel cohort studies conducted across the malaria transmission spectrum in Uganda to quantify the development of immunity against symptomatic P. falciparum as a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/35832 |
| _version_ | 1811253163968167936 |
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| author | Isabel Rodriguez-Barraquer Emmanuel Arinaitwe Prasanna Jagannathan Moses R Kamya Phillip J Rosenthal John Rek Grant Dorsey Joaniter Nankabirwa Sarah G Staedke Maxwell Kilama Chris Drakeley Isaac Ssewanyana David L Smith Bryan Greenhouse |
| author_facet | Isabel Rodriguez-Barraquer Emmanuel Arinaitwe Prasanna Jagannathan Moses R Kamya Phillip J Rosenthal John Rek Grant Dorsey Joaniter Nankabirwa Sarah G Staedke Maxwell Kilama Chris Drakeley Isaac Ssewanyana David L Smith Bryan Greenhouse |
| author_sort | Isabel Rodriguez-Barraquer |
| collection | DOAJ |
| description | Fundamental gaps remain in our understanding of how immunity to malaria develops. We used detailed clinical and entomological data from parallel cohort studies conducted across the malaria transmission spectrum in Uganda to quantify the development of immunity against symptomatic P. falciparum as a function of age and transmission intensity. We focus on: anti-parasite immunity (i.e. ability to control parasite densities) and anti-disease immunity (i.e. ability to tolerate higher parasite densities without fever). Our findings suggest a strong effect of age on both types of immunity, not explained by cumulative-exposure. They also show an independent effect of exposure, where children living in moderate/high transmission settings develop immunity faster as transmission increases. Surprisingly, children in the lowest transmission setting appear to develop immunity more efficiently than those living in moderate transmission settings. Anti-parasite and anti-disease immunity develop in parallel, reducing the probability of experiencing symptomatic malaria upon each subsequent P. falciparum infection. |
| first_indexed | 2024-04-12T16:45:45Z |
| format | Article |
| id | doaj.art-0a9cea4bab0b451d9b6bb329fefc87f8 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:45:45Z |
| publishDate | 2018-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0a9cea4bab0b451d9b6bb329fefc87f82022-12-22T03:24:34ZengeLife Sciences Publications LtdeLife2050-084X2018-07-01710.7554/eLife.35832Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposureIsabel Rodriguez-Barraquer0https://orcid.org/0000-0001-6784-1021Emmanuel Arinaitwe1Prasanna Jagannathan2https://orcid.org/0000-0001-6305-758XMoses R Kamya3Phillip J Rosenthal4John Rek5Grant Dorsey6Joaniter Nankabirwa7Sarah G Staedke8Maxwell Kilama9Chris Drakeley10https://orcid.org/0000-0003-4863-075XIsaac Ssewanyana11David L Smith12https://orcid.org/0000-0003-4367-3849Bryan Greenhouse13Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, United StatesInfectious Diseases Research Collaboration, Kampala, UgandaDepartment of Medicine, Stanford University, Stanford, United StatesDepartment of Medicine, Makerere University College of Health Sciences, Kampala, UgandaDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, United StatesInfectious Diseases Research Collaboration, Kampala, UgandaDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, United StatesInfectious Diseases Research Collaboration, Kampala, UgandaLondon School of Hygiene and Tropical Medicine, London, United KingdomInfectious Diseases Research Collaboration, Kampala, UgandaLondon School of Hygiene and Tropical Medicine, London, United KingdomInfectious Diseases Research Collaboration, Kampala, UgandaInstitute of Health Metrics and Evaluation, University of Washington, Seattle, United StatesDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, United StatesFundamental gaps remain in our understanding of how immunity to malaria develops. We used detailed clinical and entomological data from parallel cohort studies conducted across the malaria transmission spectrum in Uganda to quantify the development of immunity against symptomatic P. falciparum as a function of age and transmission intensity. We focus on: anti-parasite immunity (i.e. ability to control parasite densities) and anti-disease immunity (i.e. ability to tolerate higher parasite densities without fever). Our findings suggest a strong effect of age on both types of immunity, not explained by cumulative-exposure. They also show an independent effect of exposure, where children living in moderate/high transmission settings develop immunity faster as transmission increases. Surprisingly, children in the lowest transmission setting appear to develop immunity more efficiently than those living in moderate transmission settings. Anti-parasite and anti-disease immunity develop in parallel, reducing the probability of experiencing symptomatic malaria upon each subsequent P. falciparum infection.https://elifesciences.org/articles/35832immunitymalariaanti-parasite immunityanti-disease immunity |
| spellingShingle | Isabel Rodriguez-Barraquer Emmanuel Arinaitwe Prasanna Jagannathan Moses R Kamya Phillip J Rosenthal John Rek Grant Dorsey Joaniter Nankabirwa Sarah G Staedke Maxwell Kilama Chris Drakeley Isaac Ssewanyana David L Smith Bryan Greenhouse Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure eLife immunity malaria anti-parasite immunity anti-disease immunity |
| title | Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure |
| title_full | Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure |
| title_fullStr | Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure |
| title_full_unstemmed | Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure |
| title_short | Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure |
| title_sort | quantification of anti parasite and anti disease immunity to malaria as a function of age and exposure |
| topic | immunity malaria anti-parasite immunity anti-disease immunity |
| url | https://elifesciences.org/articles/35832 |
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