New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics
Starting with the discovery of streptomycin, the promise of natural products research on actinomycetes has been captivat¬ing researchers and offered an array of life-saving antibiotics. However, most of the actinomycetes have received a little attention of researchers beyond isolation and activity s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01295/full |
| _version_ | 1811245303263657984 |
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| author | Polpass Arul Jose Bhavanath Jha Bhavanath Jha |
| author_facet | Polpass Arul Jose Bhavanath Jha Bhavanath Jha |
| author_sort | Polpass Arul Jose |
| collection | DOAJ |
| description | Starting with the discovery of streptomycin, the promise of natural products research on actinomycetes has been captivat¬ing researchers and offered an array of life-saving antibiotics. However, most of the actinomycetes have received a little attention of researchers beyond isolation and activity screening. Noticeable gaps in genomic information and associated biosynthetic potential of actinomycetes are mainly the reasons for this situation, which has led to a decline in the discovery rate of novel antibiotics. Recent insights gained from genome mining have revealed a massive existence of previously unrecognized biosynthetic potential in actinomycetes. Successive developments in next-generation sequencing, genome editing, analytical separation and high-resolution spectroscopic methods have reinvigorated interest on such actinomycetes and opened new avenues for the discovery of natural and natural-inspired antibiotics. This article describes the new dimensions that have driven the ongoing resurgence of research on actinomycetes with historical background since the commencement in 1940, for the attention of worldwide researchers. Coupled with increasing advancement in molecular and analytical tools and techniques, the discovery of next-generation antibiotics could be possible by revisiting the untapped potential of actinomycetes from different natural sources. |
| first_indexed | 2024-04-12T14:37:41Z |
| format | Article |
| id | doaj.art-0a9f480e35494a7d8e4178c808ff45c1 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T14:37:41Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0a9f480e35494a7d8e4178c808ff45c12022-12-22T03:28:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-08-01710.3389/fmicb.2016.01295210870New Dimensions of Research on Actinomycetes: Quest for Next Generation AntibioticsPolpass Arul Jose0Bhavanath Jha1Bhavanath Jha2CSIR-Central Salt and Marine Chemicals research InstituteCSIR-Central Salt and Marine Chemicals research InstituteAcademy of Scientific and Innovative Research (AcSIR)Starting with the discovery of streptomycin, the promise of natural products research on actinomycetes has been captivat¬ing researchers and offered an array of life-saving antibiotics. However, most of the actinomycetes have received a little attention of researchers beyond isolation and activity screening. Noticeable gaps in genomic information and associated biosynthetic potential of actinomycetes are mainly the reasons for this situation, which has led to a decline in the discovery rate of novel antibiotics. Recent insights gained from genome mining have revealed a massive existence of previously unrecognized biosynthetic potential in actinomycetes. Successive developments in next-generation sequencing, genome editing, analytical separation and high-resolution spectroscopic methods have reinvigorated interest on such actinomycetes and opened new avenues for the discovery of natural and natural-inspired antibiotics. This article describes the new dimensions that have driven the ongoing resurgence of research on actinomycetes with historical background since the commencement in 1940, for the attention of worldwide researchers. Coupled with increasing advancement in molecular and analytical tools and techniques, the discovery of next-generation antibiotics could be possible by revisiting the untapped potential of actinomycetes from different natural sources.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01295/fullDrug DiscoveryGenomicsMetabolomicsActinomycetesantibioticsNatural Products |
| spellingShingle | Polpass Arul Jose Bhavanath Jha Bhavanath Jha New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics Frontiers in Microbiology Drug Discovery Genomics Metabolomics Actinomycetes antibiotics Natural Products |
| title | New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics |
| title_full | New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics |
| title_fullStr | New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics |
| title_full_unstemmed | New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics |
| title_short | New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics |
| title_sort | new dimensions of research on actinomycetes quest for next generation antibiotics |
| topic | Drug Discovery Genomics Metabolomics Actinomycetes antibiotics Natural Products |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01295/full |
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