The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients
Introduction: Chronic obstructive pulmonary disease (COPD) is associated with an oxidant-antioxidant imbalance. COPD patients have impaired cerebral vasoreactivity (CVR). Impaired CVR could be correlated with total antioxidant status (TAS) in plasma. Aim: To determine the role of systemic TAS in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Osijek
2020-11-01
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| Series: | Southeastern European Medical Journal |
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| Online Access: | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/145/86 |
| _version_ | 1818532004426153984 |
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| author | Marina Hlavati Svetlana Tomić Krunoslav Buljan Silva Butković-Soldo |
| author_facet | Marina Hlavati Svetlana Tomić Krunoslav Buljan Silva Butković-Soldo |
| author_sort | Marina Hlavati |
| collection | DOAJ |
| description | Introduction: Chronic obstructive pulmonary disease (COPD) is associated with an oxidant-antioxidant imbalance. COPD patients have impaired cerebral vasoreactivity (CVR). Impaired CVR could be correlated with total antioxidant status (TAS) in plasma.
Aim: To determine the role of systemic TAS in CVR of COPD patients.
Material and Methods: In this cross-sectional observational study, we included 120 participants (the mean age of 67±7.9, 87 males), 90 COPD patients categorized according to the severity of airway obstruction in mild, moderate, severe/very severe and 30 age- and sex-matched controls. We analyzed baseline mean flow velocities (MFV) of the middle cerebral artery (MCA) and the basilar artery (BA), the mean breath-holding index (BHIm) of those arteries (BHImMCA and BHImBA) by transcranial Doppler ultrasound and TAS in plasma. The level of significance was set to α=0.05.
Results: A significant negative correlation between TAS and BHImBA (Rho=−0.445, P=0.01) was found only in the mild COPD group. In COPD groups, baseline MFV BA is in a significant positive correlation with BHImMCA and BHImBA (Rho=0.336, P=0.001 and Rho=0.647, P<0.001). According to the severity of airway obstruction in COPD groups, a significant positive correlation between baseline MFV BA and BHImBA was found: in mild (Rho=0.731, P<0.001), moderate (Rho=0.574, P=0.001) and severe/very severe (Rho=0.398, P=0.03).
Conclusion: Systemic TAS was not correlated with CVR in all COPD groups. However, perfusion in the BA of COPD groups was in a significant positive correlation with the anterior and posterior CVR. The analysis of perfusion in the basal cerebral arteries should be part of a future study of CVR in COPD patients. |
| first_indexed | 2024-12-11T17:39:52Z |
| format | Article |
| id | doaj.art-0aa1ec1e9cc849bba6e08022e19335d4 |
| institution | Directory Open Access Journal |
| issn | 2459-9484 |
| language | English |
| last_indexed | 2024-12-11T17:39:52Z |
| publishDate | 2020-11-01 |
| publisher | Faculty of Medicine Osijek |
| record_format | Article |
| series | Southeastern European Medical Journal |
| spelling | doaj.art-0aa1ec1e9cc849bba6e08022e19335d42022-12-22T00:56:33ZengFaculty of Medicine OsijekSoutheastern European Medical Journal2459-94842020-11-0142486110.26332/seemedj.v4i2.145The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease PatientsMarina Hlavati0https://orcid.org/0000-0002-7931-2423Svetlana Tomić1Krunoslav Buljan2Silva Butković-Soldo3Department for Diagnostic and Therapeutical Procedures-Neurology Unit, General Hospital Našice, Croatia; Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, CroatiaFaculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, CroatiaFaculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, CroatiaFaculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, CroatiaIntroduction: Chronic obstructive pulmonary disease (COPD) is associated with an oxidant-antioxidant imbalance. COPD patients have impaired cerebral vasoreactivity (CVR). Impaired CVR could be correlated with total antioxidant status (TAS) in plasma. Aim: To determine the role of systemic TAS in CVR of COPD patients. Material and Methods: In this cross-sectional observational study, we included 120 participants (the mean age of 67±7.9, 87 males), 90 COPD patients categorized according to the severity of airway obstruction in mild, moderate, severe/very severe and 30 age- and sex-matched controls. We analyzed baseline mean flow velocities (MFV) of the middle cerebral artery (MCA) and the basilar artery (BA), the mean breath-holding index (BHIm) of those arteries (BHImMCA and BHImBA) by transcranial Doppler ultrasound and TAS in plasma. The level of significance was set to α=0.05. Results: A significant negative correlation between TAS and BHImBA (Rho=−0.445, P=0.01) was found only in the mild COPD group. In COPD groups, baseline MFV BA is in a significant positive correlation with BHImMCA and BHImBA (Rho=0.336, P=0.001 and Rho=0.647, P<0.001). According to the severity of airway obstruction in COPD groups, a significant positive correlation between baseline MFV BA and BHImBA was found: in mild (Rho=0.731, P<0.001), moderate (Rho=0.574, P=0.001) and severe/very severe (Rho=0.398, P=0.03). Conclusion: Systemic TAS was not correlated with CVR in all COPD groups. However, perfusion in the BA of COPD groups was in a significant positive correlation with the anterior and posterior CVR. The analysis of perfusion in the basal cerebral arteries should be part of a future study of CVR in COPD patients.http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/145/86chronic obstructive pulmonary diseaseantioxidantstranscranial doppler ultrasonographybreath-holdingcerebral perfusion |
| spellingShingle | Marina Hlavati Svetlana Tomić Krunoslav Buljan Silva Butković-Soldo The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients Southeastern European Medical Journal chronic obstructive pulmonary disease antioxidants transcranial doppler ultrasonography breath-holding cerebral perfusion |
| title | The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients |
| title_full | The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients |
| title_fullStr | The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients |
| title_full_unstemmed | The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients |
| title_short | The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients |
| title_sort | role of total antioxidant status in cerebral vasoreactivity of chronic obstructive pulmonary disease patients |
| topic | chronic obstructive pulmonary disease antioxidants transcranial doppler ultrasonography breath-holding cerebral perfusion |
| url | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/145/86 |
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