Association between bile acid metabolism and bone mineral density in postmenopausal women
OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2020-03-01
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| Series: | Clinics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100218&tlng=en |
| _version_ | 1818859473752555520 |
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| author | Yu-Xiao Zhao Yu-Wen Song Liang Zhang Feng-Jie Zheng Xue-Meng Wang Xiang-Hua Zhuang Fei Wu Jian Liu |
| author_facet | Yu-Xiao Zhao Yu-Wen Song Liang Zhang Feng-Jie Zheng Xue-Meng Wang Xiang-Hua Zhuang Fei Wu Jian Liu |
| author_sort | Yu-Xiao Zhao |
| collection | DOAJ |
| description | OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (β-CTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with β-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism. |
| first_indexed | 2024-12-19T09:12:45Z |
| format | Article |
| id | doaj.art-0aa243acc50d4cb8868515f415c3f329 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-19T09:12:45Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-0aa243acc50d4cb8868515f415c3f3292022-12-21T20:28:10ZengElsevier EspañaClinics1980-53222020-03-017510.6061/clinics/2020/e1486Association between bile acid metabolism and bone mineral density in postmenopausal womenYu-Xiao ZhaoYu-Wen SongLiang ZhangFeng-Jie ZhengXue-Meng WangXiang-Hua ZhuangFei WuJian Liuhttps://orcid.org/0000-0002-0801-6811OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (β-CTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with β-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100218&tlng=enPostmenopausal OsteoporosisBile Acid MetabolismFGF19 |
| spellingShingle | Yu-Xiao Zhao Yu-Wen Song Liang Zhang Feng-Jie Zheng Xue-Meng Wang Xiang-Hua Zhuang Fei Wu Jian Liu Association between bile acid metabolism and bone mineral density in postmenopausal women Clinics Postmenopausal Osteoporosis Bile Acid Metabolism FGF19 |
| title | Association between bile acid metabolism and bone mineral density in postmenopausal women |
| title_full | Association between bile acid metabolism and bone mineral density in postmenopausal women |
| title_fullStr | Association between bile acid metabolism and bone mineral density in postmenopausal women |
| title_full_unstemmed | Association between bile acid metabolism and bone mineral density in postmenopausal women |
| title_short | Association between bile acid metabolism and bone mineral density in postmenopausal women |
| title_sort | association between bile acid metabolism and bone mineral density in postmenopausal women |
| topic | Postmenopausal Osteoporosis Bile Acid Metabolism FGF19 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100218&tlng=en |
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