Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience
Shreya Swaminathan,1,* Jacob Ruzevick,1,* Vyshak Venur,2 Lia M Halasz,3 Jason Rockhill,3 Luis Gonzalez-Cuyar,4 Lee D Cranmer,2 Manuel Ferreira Jnr1 1Department of Neurological Surgery, The University of Washington School of Medicine, Seattle, WA, USA; 2Division of Medical Oncology, D...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-09-01
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| Series: | Therapeutics and Clinical Risk Management |
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| Online Access: | https://www.dovepress.com/intracranial-solitary-fibrous-tumorhemangiopericytoma-treated-with-mic-peer-reviewed-fulltext-article-TCRM |
| _version_ | 1818483169475690496 |
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| author | Swaminathan S Ruzevick J Venur V Halasz LM Rockhill J Gonzalez-Cuyar L Cranmer LD Ferreira Jnr M |
| author_facet | Swaminathan S Ruzevick J Venur V Halasz LM Rockhill J Gonzalez-Cuyar L Cranmer LD Ferreira Jnr M |
| author_sort | Swaminathan S |
| collection | DOAJ |
| description | Shreya Swaminathan,1,* Jacob Ruzevick,1,* Vyshak Venur,2 Lia M Halasz,3 Jason Rockhill,3 Luis Gonzalez-Cuyar,4 Lee D Cranmer,2 Manuel Ferreira Jnr1 1Department of Neurological Surgery, The University of Washington School of Medicine, Seattle, WA, USA; 2Division of Medical Oncology, Department of Medicine, The University of Washington School of Medicine, Seattle, WA, USA; 3Department of Radiation Oncology, The University of Washington School of Medicine, Seattle, WA, USA; 4Department of Laboratory Medicine and Pathology, Division of Neuropathology, The University of Washington School of Medicine, Seattle, WA, USA*These authors contributed equally to this workCorrespondence: Lee D Cranmer, University of Washington School of Medicine, Division of Medical Oncology, 825 Eastlake Ave. East, LG-350, Seattle, WA, 98109, USA, Tel +1 206 606-7439, Email lcranmer@seattlecca.orgObjective: To provide benchmarks for further studies of solitary fibrous tumor/hemangiopericytoma (SFT/HPC) of the central nervous system (CNS), we investigated the association of baseline demographic, clinico-pathologic, and treatment factors with outcomes in those treated at our center.Methods: We conducted a retrospective, cohort analysis of patients treated for SFT/HPC at the University of Washington 1990– 2020. Kaplan-Meier and univariable Cox analyses assessed relationships between baseline variables and local or global CNS recurrence, extraneural recurrence, progression-free survival (PFS) and overall survival (OS).Results: Among 34 eligible patients, median duration of follow-up was 79 months (range 13– 318 months). Local and global CNS recurrence occurred at a median of 81 m (95% CI 48– 151) and 81 m (95% CI 47– 112), respectively. Extraneural metastases occurred at a median 248 m (95% CI 180-Not Reached) and only in grade 3 tumors. Median PFS and OS were 76 months (95% CI: 47– 109 months) and 210 months (95% CI 131– 306 months), respectively. Univariable Cox analyses showed that age at diagnosis was associated with local (p = 0.01) and global CNS relapse (p = 0.01), and PFS (p = 0.03). Gross total resection was associated with decreased local or global CNS relapse (p = 0.02) and improved PFS (p = 0.03); peri-operative radiation was associated with decreased local CNS relapse (p = 0.02).Conclusion: Following microsurgical resection of SFT/HPC, CNS relapse is common and associated with age, extent of resection, and adjuvant radiation. Extraneural relapse occurs in some patients. Delayed time-to-initial relapse justifies prolonged surveillance, but optimal approaches have not been defined.Keywords: solitary fibrous tumor, hemangiopericytoma, radiotherapy, embolization, adjuvant |
| first_indexed | 2024-12-10T11:56:47Z |
| format | Article |
| id | doaj.art-0aa380cb1fef4c10878ad0c878a8c0d6 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-10T11:56:47Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-0aa380cb1fef4c10878ad0c878a8c0d62022-12-22T01:49:45ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2022-09-01Volume 1890191277955Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center ExperienceSwaminathan SRuzevick JVenur VHalasz LMRockhill JGonzalez-Cuyar LCranmer LDFerreira Jnr MShreya Swaminathan,1,* Jacob Ruzevick,1,* Vyshak Venur,2 Lia M Halasz,3 Jason Rockhill,3 Luis Gonzalez-Cuyar,4 Lee D Cranmer,2 Manuel Ferreira Jnr1 1Department of Neurological Surgery, The University of Washington School of Medicine, Seattle, WA, USA; 2Division of Medical Oncology, Department of Medicine, The University of Washington School of Medicine, Seattle, WA, USA; 3Department of Radiation Oncology, The University of Washington School of Medicine, Seattle, WA, USA; 4Department of Laboratory Medicine and Pathology, Division of Neuropathology, The University of Washington School of Medicine, Seattle, WA, USA*These authors contributed equally to this workCorrespondence: Lee D Cranmer, University of Washington School of Medicine, Division of Medical Oncology, 825 Eastlake Ave. East, LG-350, Seattle, WA, 98109, USA, Tel +1 206 606-7439, Email lcranmer@seattlecca.orgObjective: To provide benchmarks for further studies of solitary fibrous tumor/hemangiopericytoma (SFT/HPC) of the central nervous system (CNS), we investigated the association of baseline demographic, clinico-pathologic, and treatment factors with outcomes in those treated at our center.Methods: We conducted a retrospective, cohort analysis of patients treated for SFT/HPC at the University of Washington 1990– 2020. Kaplan-Meier and univariable Cox analyses assessed relationships between baseline variables and local or global CNS recurrence, extraneural recurrence, progression-free survival (PFS) and overall survival (OS).Results: Among 34 eligible patients, median duration of follow-up was 79 months (range 13– 318 months). Local and global CNS recurrence occurred at a median of 81 m (95% CI 48– 151) and 81 m (95% CI 47– 112), respectively. Extraneural metastases occurred at a median 248 m (95% CI 180-Not Reached) and only in grade 3 tumors. Median PFS and OS were 76 months (95% CI: 47– 109 months) and 210 months (95% CI 131– 306 months), respectively. Univariable Cox analyses showed that age at diagnosis was associated with local (p = 0.01) and global CNS relapse (p = 0.01), and PFS (p = 0.03). Gross total resection was associated with decreased local or global CNS relapse (p = 0.02) and improved PFS (p = 0.03); peri-operative radiation was associated with decreased local CNS relapse (p = 0.02).Conclusion: Following microsurgical resection of SFT/HPC, CNS relapse is common and associated with age, extent of resection, and adjuvant radiation. Extraneural relapse occurs in some patients. Delayed time-to-initial relapse justifies prolonged surveillance, but optimal approaches have not been defined.Keywords: solitary fibrous tumor, hemangiopericytoma, radiotherapy, embolization, adjuvanthttps://www.dovepress.com/intracranial-solitary-fibrous-tumorhemangiopericytoma-treated-with-mic-peer-reviewed-fulltext-article-TCRMsolitary fibrous tumorhemangiopericytomaradiotherapyembolizationadjuvant |
| spellingShingle | Swaminathan S Ruzevick J Venur V Halasz LM Rockhill J Gonzalez-Cuyar L Cranmer LD Ferreira Jnr M Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience Therapeutics and Clinical Risk Management solitary fibrous tumor hemangiopericytoma radiotherapy embolization adjuvant |
| title | Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience |
| title_full | Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience |
| title_fullStr | Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience |
| title_full_unstemmed | Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience |
| title_short | Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Treated with Microsurgical Resection: Retrospective Cohort Analysis of a Single-Center Experience |
| title_sort | intracranial solitary fibrous tumor hemangiopericytoma treated with microsurgical resection retrospective cohort analysis of a single center experience |
| topic | solitary fibrous tumor hemangiopericytoma radiotherapy embolization adjuvant |
| url | https://www.dovepress.com/intracranial-solitary-fibrous-tumorhemangiopericytoma-treated-with-mic-peer-reviewed-fulltext-article-TCRM |
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