Anatomical alterations of the visual motion processing network in migraine with and without aura.
Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2006-10-01
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| Series: | PLoS Medicine |
| Online Access: | http://europepmc.org/articles/PMC1609120?pdf=render |
| _version_ | 1811268696160600064 |
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| author | Cristina Granziera Alexandre F M DaSilva Josh Snyder David S Tuch Nouchine Hadjikhani |
| author_facet | Cristina Granziera Alexandre F M DaSilva Josh Snyder David S Tuch Nouchine Hadjikhani |
| author_sort | Cristina Granziera |
| collection | DOAJ |
| description | Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine.To investigate a common potential anatomical basis for these disturbances, we used high-resolution cortical thickness measurement and diffusion tensor imaging (DTI) to examine the motion-processing network in 24 migraine patients (12 with MWA and 12 MWoA) and 15 age-matched healthy controls (HCs). We found increased cortical thickness of motion-processing visual areas MT+ and V3A in migraineurs compared to HCs. Cortical thickness increases were accompanied by abnormalities of the subjacent white matter. In addition, DTI revealed that migraineurs have alterations in superior colliculus and the lateral geniculate nucleus, which are also involved in visual processing.A structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability observed in migraineurs. The finding in patients with both MWA and MWoA of thickness abnormalities in area V3A, previously described as a source in spreading changes involved in visual aura, raises the question as to whether a "silent" cortical spreading depression develops as well in MWoA. In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker. |
| first_indexed | 2024-04-12T21:27:32Z |
| format | Article |
| id | doaj.art-0aa431b6275d447782084888247b51ce |
| institution | Directory Open Access Journal |
| issn | 1549-1277 1549-1676 |
| language | English |
| last_indexed | 2024-04-12T21:27:32Z |
| publishDate | 2006-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj.art-0aa431b6275d447782084888247b51ce2022-12-22T03:16:08ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762006-10-01310e40210.1371/journal.pmed.0030402Anatomical alterations of the visual motion processing network in migraine with and without aura.Cristina GranzieraAlexandre F M DaSilvaJosh SnyderDavid S TuchNouchine HadjikhaniPatients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine.To investigate a common potential anatomical basis for these disturbances, we used high-resolution cortical thickness measurement and diffusion tensor imaging (DTI) to examine the motion-processing network in 24 migraine patients (12 with MWA and 12 MWoA) and 15 age-matched healthy controls (HCs). We found increased cortical thickness of motion-processing visual areas MT+ and V3A in migraineurs compared to HCs. Cortical thickness increases were accompanied by abnormalities of the subjacent white matter. In addition, DTI revealed that migraineurs have alterations in superior colliculus and the lateral geniculate nucleus, which are also involved in visual processing.A structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability observed in migraineurs. The finding in patients with both MWA and MWoA of thickness abnormalities in area V3A, previously described as a source in spreading changes involved in visual aura, raises the question as to whether a "silent" cortical spreading depression develops as well in MWoA. In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker.http://europepmc.org/articles/PMC1609120?pdf=render |
| spellingShingle | Cristina Granziera Alexandre F M DaSilva Josh Snyder David S Tuch Nouchine Hadjikhani Anatomical alterations of the visual motion processing network in migraine with and without aura. PLoS Medicine |
| title | Anatomical alterations of the visual motion processing network in migraine with and without aura. |
| title_full | Anatomical alterations of the visual motion processing network in migraine with and without aura. |
| title_fullStr | Anatomical alterations of the visual motion processing network in migraine with and without aura. |
| title_full_unstemmed | Anatomical alterations of the visual motion processing network in migraine with and without aura. |
| title_short | Anatomical alterations of the visual motion processing network in migraine with and without aura. |
| title_sort | anatomical alterations of the visual motion processing network in migraine with and without aura |
| url | http://europepmc.org/articles/PMC1609120?pdf=render |
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