Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method
Human microRNAs play crucial role in the modulation of gene expression in case of host pathogen interaction. Infection by Pseudomonas aeruginosa results into dysregulated expression of different microRNAs which modulate the immune response and survival of the pathogen in course of the infection. Evi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Informatics in Medicine Unlocked |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352914822002477 |
| _version_ | 1811231065204850688 |
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| author | Malabika Chakrabarti Tanima Saha |
| author_facet | Malabika Chakrabarti Tanima Saha |
| author_sort | Malabika Chakrabarti |
| collection | DOAJ |
| description | Human microRNAs play crucial role in the modulation of gene expression in case of host pathogen interaction. Infection by Pseudomonas aeruginosa results into dysregulated expression of different microRNAs which modulate the immune response and survival of the pathogen in course of the infection. Evidences of inter-kingdom signaling mediated by short, non-coding RNAs between the human host and Pseudomonas aeruginosa have been found in the previous studies. In this article, an in silico hybridization method was used to identify some candidate human microRNAs having probable binding ability with Pseudomonas aeruginosa mRNAs. The work may provide further insights to the development of novel therapeutics against the pathogen causing multi-drug resistant infections. |
| first_indexed | 2024-04-12T10:39:57Z |
| format | Article |
| id | doaj.art-0aa4c70a588a4f039dbf8efc7dc3dc75 |
| institution | Directory Open Access Journal |
| issn | 2352-9148 |
| language | English |
| last_indexed | 2024-04-12T10:39:57Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Informatics in Medicine Unlocked |
| spelling | doaj.art-0aa4c70a588a4f039dbf8efc7dc3dc752022-12-22T03:36:38ZengElsevierInformatics in Medicine Unlocked2352-91482022-01-0134101110Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization methodMalabika Chakrabarti0Tanima Saha1Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani, Nadia, 741235, West Bengal, IndiaCorresponding author.; Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani, Nadia, 741235, West Bengal, IndiaHuman microRNAs play crucial role in the modulation of gene expression in case of host pathogen interaction. Infection by Pseudomonas aeruginosa results into dysregulated expression of different microRNAs which modulate the immune response and survival of the pathogen in course of the infection. Evidences of inter-kingdom signaling mediated by short, non-coding RNAs between the human host and Pseudomonas aeruginosa have been found in the previous studies. In this article, an in silico hybridization method was used to identify some candidate human microRNAs having probable binding ability with Pseudomonas aeruginosa mRNAs. The work may provide further insights to the development of novel therapeutics against the pathogen causing multi-drug resistant infections.http://www.sciencedirect.com/science/article/pii/S2352914822002477microRNAPseudomonas aeruginosaInfectionIn silico hybridization |
| spellingShingle | Malabika Chakrabarti Tanima Saha Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method Informatics in Medicine Unlocked microRNA Pseudomonas aeruginosa Infection In silico hybridization |
| title | Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method |
| title_full | Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method |
| title_fullStr | Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method |
| title_full_unstemmed | Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method |
| title_short | Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an in silico hybridization method |
| title_sort | identification of human micrornas targeting pseudomonas aeruginosa genes by an in silico hybridization method |
| topic | microRNA Pseudomonas aeruginosa Infection In silico hybridization |
| url | http://www.sciencedirect.com/science/article/pii/S2352914822002477 |
| work_keys_str_mv | AT malabikachakrabarti identificationofhumanmicrornastargetingpseudomonasaeruginosagenesbyaninsilicohybridizationmethod AT tanimasaha identificationofhumanmicrornastargetingpseudomonasaeruginosagenesbyaninsilicohybridizationmethod |