Treatment for cholangiohepatitis in cats
Acute bacterial cholangiohepatitis of cats is a common disease associated with the inflammation of bile ducts and liver parenchyma, characterized by development of a pronounced hepatodepressive syndrome (hypoalbuminemia), cytolysis (increase in serum activity of alanine and asparagine transaminase),...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Peoples’ Friendship University of Russia (RUDN University)
2023-03-01
|
| Series: | RUDN Journal of Agronomy and Animal Industries |
| Subjects: | |
| Online Access: | https://agrojournal.rudn.ru/agronomy/article/viewFile/19872/16349 |
| _version_ | 1797850684390899712 |
|---|---|
| author | Andrei A. Rudenko Arfenia S. Karamyan Denis S. Usenko Elena A. Krotova Roman V. Rogov Ivan E. Prozorovskiy |
| author_facet | Andrei A. Rudenko Arfenia S. Karamyan Denis S. Usenko Elena A. Krotova Roman V. Rogov Ivan E. Prozorovskiy |
| author_sort | Andrei A. Rudenko |
| collection | DOAJ |
| description | Acute bacterial cholangiohepatitis of cats is a common disease associated with the inflammation of bile ducts and liver parenchyma, characterized by development of a pronounced hepatodepressive syndrome (hypoalbuminemia), cytolysis (increase in serum activity of alanine and asparagine transaminase), cholestasis (increase in serum concentration of bilirubin, cholesterol, activity of alkaline phosphatase and gamma-glutamyltranspeptidase), intoxication, dehydration, mesenchymal-inflammatory and pain syndromes. The aim of the research was to study the effectiveness of treatment for acute bacterial cholangiohepatitis in cats with average severity of the pathology course. According to inclusion and exclusion criteria, the study included a cohort of cats (n = 12) with acute bacterial cholangiohepatitis. Clinical, hematological, ultrasonographic, statistical methods of investigation were used in this work. For sick cats with medium severity form of cholangiohepatitis, when administered as a complex therapy the combination of marbofloxacin, metronidazole, ursodeoxycholic acid, cyancobolamine, tocopherol acetate, infusion therapy also had a good therapeutic effect, which was accompanied by improved clinical and laboratory performance. In the blood of cats with cholangiohepatitis, in the background of intensive therapy, there was a significant decrease in white blood cell count, erythrocyte sedimentation rate, and in serum, there was an increase in albumin concentration, reduction of creatinine, aminotransferase activity, alkaline phosphatase, gamma-glutamyltranspeptidase, lipase. |
| first_indexed | 2024-04-09T19:05:25Z |
| format | Article |
| id | doaj.art-0aa6f31e63794fe0b74775fef0fc624f |
| institution | Directory Open Access Journal |
| issn | 2312-797X 2312-7988 |
| language | English |
| last_indexed | 2024-04-09T19:05:25Z |
| publishDate | 2023-03-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Agronomy and Animal Industries |
| spelling | doaj.art-0aa6f31e63794fe0b74775fef0fc624f2023-04-07T10:07:19ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Agronomy and Animal Industries2312-797X2312-79882023-03-0118113514410.22363/2312-797X-2023-18-1-135-14417016Treatment for cholangiohepatitis in catsAndrei A. Rudenko0https://orcid.org/0000-0002-6434-3497Arfenia S. Karamyan1Denis S. Usenko2https://orcid.org/0000-0002-3757-9998Elena A. Krotova3https://orcid.org/0000-0003-1771-6091Roman V. Rogov4https://orcid.org/0000-0002-3010-5714Ivan E. Prozorovskiy5https://orcid.org/0000-0002-1849-3849Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Lugansk State Agrarian UniversityPeoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Acute bacterial cholangiohepatitis of cats is a common disease associated with the inflammation of bile ducts and liver parenchyma, characterized by development of a pronounced hepatodepressive syndrome (hypoalbuminemia), cytolysis (increase in serum activity of alanine and asparagine transaminase), cholestasis (increase in serum concentration of bilirubin, cholesterol, activity of alkaline phosphatase and gamma-glutamyltranspeptidase), intoxication, dehydration, mesenchymal-inflammatory and pain syndromes. The aim of the research was to study the effectiveness of treatment for acute bacterial cholangiohepatitis in cats with average severity of the pathology course. According to inclusion and exclusion criteria, the study included a cohort of cats (n = 12) with acute bacterial cholangiohepatitis. Clinical, hematological, ultrasonographic, statistical methods of investigation were used in this work. For sick cats with medium severity form of cholangiohepatitis, when administered as a complex therapy the combination of marbofloxacin, metronidazole, ursodeoxycholic acid, cyancobolamine, tocopherol acetate, infusion therapy also had a good therapeutic effect, which was accompanied by improved clinical and laboratory performance. In the blood of cats with cholangiohepatitis, in the background of intensive therapy, there was a significant decrease in white blood cell count, erythrocyte sedimentation rate, and in serum, there was an increase in albumin concentration, reduction of creatinine, aminotransferase activity, alkaline phosphatase, gamma-glutamyltranspeptidase, lipase.https://agrojournal.rudn.ru/agronomy/article/viewFile/19872/16349cholangitishepatitiseffectiveness of treatmentanalgesiamarbofloxacinmetrogylurodeoxycholic acidlidocainemaropitantgabapentin |
| spellingShingle | Andrei A. Rudenko Arfenia S. Karamyan Denis S. Usenko Elena A. Krotova Roman V. Rogov Ivan E. Prozorovskiy Treatment for cholangiohepatitis in cats RUDN Journal of Agronomy and Animal Industries cholangitis hepatitis effectiveness of treatment analgesia marbofloxacin metrogyl urodeoxycholic acid lidocaine maropitant gabapentin |
| title | Treatment for cholangiohepatitis in cats |
| title_full | Treatment for cholangiohepatitis in cats |
| title_fullStr | Treatment for cholangiohepatitis in cats |
| title_full_unstemmed | Treatment for cholangiohepatitis in cats |
| title_short | Treatment for cholangiohepatitis in cats |
| title_sort | treatment for cholangiohepatitis in cats |
| topic | cholangitis hepatitis effectiveness of treatment analgesia marbofloxacin metrogyl urodeoxycholic acid lidocaine maropitant gabapentin |
| url | https://agrojournal.rudn.ru/agronomy/article/viewFile/19872/16349 |
| work_keys_str_mv | AT andreiarudenko treatmentforcholangiohepatitisincats AT arfeniaskaramyan treatmentforcholangiohepatitisincats AT denissusenko treatmentforcholangiohepatitisincats AT elenaakrotova treatmentforcholangiohepatitisincats AT romanvrogov treatmentforcholangiohepatitisincats AT ivaneprozorovskiy treatmentforcholangiohepatitisincats |