ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer
Background: Colon adenocarcinoma (COAD) is a common digestive system tumor in the world. However, the role and function of ISYNA1 (inositol-3-phosphate synthase 1) in COAD remain unclear. We aim to explore the role of ISYNA1 in pan-cancer, especially in COAD.Methods: The expression, clinical charact...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.792564/full |
| _version_ | 1819279096066080768 |
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| author | Zeming Jia Xiaoping Wan |
| author_facet | Zeming Jia Xiaoping Wan |
| author_sort | Zeming Jia |
| collection | DOAJ |
| description | Background: Colon adenocarcinoma (COAD) is a common digestive system tumor in the world. However, the role and function of ISYNA1 (inositol-3-phosphate synthase 1) in COAD remain unclear. We aim to explore the role of ISYNA1 in pan-cancer, especially in COAD.Methods: The expression, clinical characteristic, and prognosis of ISYNA1 in pan-cancer were evaluated using the TCGA (the Cancer Genome Atlas), GTEx (the Genotype-Tissue Expression), and CCLE (Cancer Cell Line Encyclopedia). Pathway enrichment analysis of ISYNA1 was conducted using the R package “clusterProfiler.” We analyzed the correlation between the immune cell infiltration level and ISYNA1 expression using two sources of immune cell infiltration data, including the TIMER online database and ImmuCellAI database.Results: ISYNA1 was highly expressed in COAD and other cancer types compared with respective normal tissues. High ISYNA1 expression predicted poorer survival in COAD. We also found that ISYNA1 expression was positively correlated with the infiltration level of tumor-associated macrophages and tumor-associated fibroblasts in COAD.Conclusion: In conclusion, our findings revealed ISYNA1 to be a potential prognostic biomarker in COAD. High ISYNA1 expression indicates the immunosuppressive microenvironment. |
| first_indexed | 2024-12-24T00:22:28Z |
| format | Article |
| id | doaj.art-0aa7e55e05fc48f387ae1e8d5cf48ee9 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-24T00:22:28Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-0aa7e55e05fc48f387ae1e8d5cf48ee92022-12-21T17:24:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-02-011010.3389/fcell.2022.792564792564ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-CancerZeming JiaXiaoping WanBackground: Colon adenocarcinoma (COAD) is a common digestive system tumor in the world. However, the role and function of ISYNA1 (inositol-3-phosphate synthase 1) in COAD remain unclear. We aim to explore the role of ISYNA1 in pan-cancer, especially in COAD.Methods: The expression, clinical characteristic, and prognosis of ISYNA1 in pan-cancer were evaluated using the TCGA (the Cancer Genome Atlas), GTEx (the Genotype-Tissue Expression), and CCLE (Cancer Cell Line Encyclopedia). Pathway enrichment analysis of ISYNA1 was conducted using the R package “clusterProfiler.” We analyzed the correlation between the immune cell infiltration level and ISYNA1 expression using two sources of immune cell infiltration data, including the TIMER online database and ImmuCellAI database.Results: ISYNA1 was highly expressed in COAD and other cancer types compared with respective normal tissues. High ISYNA1 expression predicted poorer survival in COAD. We also found that ISYNA1 expression was positively correlated with the infiltration level of tumor-associated macrophages and tumor-associated fibroblasts in COAD.Conclusion: In conclusion, our findings revealed ISYNA1 to be a potential prognostic biomarker in COAD. High ISYNA1 expression indicates the immunosuppressive microenvironment.https://www.frontiersin.org/articles/10.3389/fcell.2022.792564/fullTCGAISYNA1colon adenocarcinomaprognostic biomarkermacrophagesimmunosuppressive microenvironment |
| spellingShingle | Zeming Jia Xiaoping Wan ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer Frontiers in Cell and Developmental Biology TCGA ISYNA1 colon adenocarcinoma prognostic biomarker macrophages immunosuppressive microenvironment |
| title | ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer |
| title_full | ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer |
| title_fullStr | ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer |
| title_full_unstemmed | ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer |
| title_short | ISYNA1: An Immunomodulatory-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer |
| title_sort | isyna1 an immunomodulatory related prognostic biomarker in colon adenocarcinoma and pan cancer |
| topic | TCGA ISYNA1 colon adenocarcinoma prognostic biomarker macrophages immunosuppressive microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.792564/full |
| work_keys_str_mv | AT zemingjia isyna1animmunomodulatoryrelatedprognosticbiomarkerincolonadenocarcinomaandpancancer AT xiaopingwan isyna1animmunomodulatoryrelatedprognosticbiomarkerincolonadenocarcinomaandpancancer |