A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases
Abstract Background & aim: Non-alcoholic liver disease is the main liver disease associated with malnourished diet and overweight habits. The purpose of this study was to compare the effects of 8 weeks of intense intolerant training (HIIT) and low intensity endurance training (LIET) on Hig2 gen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2019-01-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/article-1-2215-en.html |
| _version_ | 1818027840334987264 |
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| author | M Bagheri A Azamian Nazari E Bani Talebi MH Nasr Esfahani |
| author_facet | M Bagheri A Azamian Nazari E Bani Talebi MH Nasr Esfahani |
| author_sort | M Bagheri |
| collection | DOAJ |
| description | Abstract
Background & aim: Non-alcoholic liver disease is the main liver disease associated with malnourished diet and overweight habits. The purpose of this study was to compare the effects of 8 weeks of intense intolerant training (HIIT) and low intensity endurance training (LIET) on Hig2 gene expression and liver triglyceride content in fatty liver (NAFLD) rats.
Methods: In the present experimental study, 40 male wistar rats were randomly divided into four equal groups. The control group, LIET and HIIT, who consumed high fatty foods for the first sixteen weeks with the aim of developing fatty liver, and the sham group that used standard food during this period. The HIIT group's practice consisted of stages of extreme riding based on a percentage of maximum speed, which was separated by low-intensity running as active rest. The practice of the LIET group was also matched according to the distance traveled by the HIIT group. At the end of 8 weeks of training, the expression of Hig2 gene and liver fat content were measured. The collected data were analyzed using Kruskal-Wallis statistical tests.
Results: A significant difference was seen between the two groups in the expression of Hig2 (P = 0.026) and IHL (K2 = 32.84, p = 0.001). Significant differences were observed in Hig2 between the control group and the HIIT group (p = 0.031) and the control group with PID (p = 0.012), but no significant differences were observed in Hig2 between the HIIT group and the IR group (453/0 = p). Also, there were significant differences in IHL between control group and HIIT (p = 0.001) and control group with PID (p = 0.001). Also, there were significant differences in IHL between HIIT group and IR group (p = 0.003).
Conclusion: Severe periodic exercises and low-intensity continuous exercises by reducing the expression of Hig2 gene reduce the content of liver fat and improve NAFLD. Also, the reduction of liver fat in the severe periodic exercise group occurs independently of weight loss. |
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| institution | Directory Open Access Journal |
| issn | 1728-6514 1728-6514 |
| language | fas |
| last_indexed | 2024-12-10T04:54:17Z |
| publishDate | 2019-01-01 |
| publisher | Yasuj University Of Medical Sciences |
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| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-0aa8babe93344cb59b9e6ec15e1b18d02022-12-22T02:01:32ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65141728-65142019-01-01236666682A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver DiseasesM Bagheri0A Azamian Nazari1E Bani Talebi2MH Nasr Esfahani3 Department of Sports Physiology, Shahrekord University, Shahrekord, Iran, Department of Sport Sciences, Shahrekord University, Shahrekord, Iran Department of Sport Sciences, Shahrekord University, Shahrekord, Iran Royan Biotechnology Research Center, Isfahan, Iran Abstract Background & aim: Non-alcoholic liver disease is the main liver disease associated with malnourished diet and overweight habits. The purpose of this study was to compare the effects of 8 weeks of intense intolerant training (HIIT) and low intensity endurance training (LIET) on Hig2 gene expression and liver triglyceride content in fatty liver (NAFLD) rats. Methods: In the present experimental study, 40 male wistar rats were randomly divided into four equal groups. The control group, LIET and HIIT, who consumed high fatty foods for the first sixteen weeks with the aim of developing fatty liver, and the sham group that used standard food during this period. The HIIT group's practice consisted of stages of extreme riding based on a percentage of maximum speed, which was separated by low-intensity running as active rest. The practice of the LIET group was also matched according to the distance traveled by the HIIT group. At the end of 8 weeks of training, the expression of Hig2 gene and liver fat content were measured. The collected data were analyzed using Kruskal-Wallis statistical tests. Results: A significant difference was seen between the two groups in the expression of Hig2 (P = 0.026) and IHL (K2 = 32.84, p = 0.001). Significant differences were observed in Hig2 between the control group and the HIIT group (p = 0.031) and the control group with PID (p = 0.012), but no significant differences were observed in Hig2 between the HIIT group and the IR group (453/0 = p). Also, there were significant differences in IHL between control group and HIIT (p = 0.001) and control group with PID (p = 0.001). Also, there were significant differences in IHL between HIIT group and IR group (p = 0.003). Conclusion: Severe periodic exercises and low-intensity continuous exercises by reducing the expression of Hig2 gene reduce the content of liver fat and improve NAFLD. Also, the reduction of liver fat in the severe periodic exercise group occurs independently of weight loss.http://armaghanj.yums.ac.ir/article-1-2215-en.htmlNon-alcoholic fatty liverSevere periodic exerciseLow endurance trainingProtein derived from gene 2 induction of hypoxiaintrahepatic fatty |
| spellingShingle | M Bagheri A Azamian Nazari E Bani Talebi MH Nasr Esfahani A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases Armaghane Danesh Bimonthly Journal Non-alcoholic fatty liver Severe periodic exercise Low endurance training Protein derived from gene 2 induction of hypoxia intrahepatic fatty |
| title | A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases |
| title_full | A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases |
| title_fullStr | A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases |
| title_full_unstemmed | A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases |
| title_short | A Comparison Between the Effects of Eight Weeks of High Intensity Interval Training and Low Intensity Endurance Training on Expression of Hig2 and Intrahepatic Lipid Content in Rats with Non-Alcoholic Fatty Liver Diseases |
| title_sort | comparison between the effects of eight weeks of high intensity interval training and low intensity endurance training on expression of hig2 and intrahepatic lipid content in rats with non alcoholic fatty liver diseases |
| topic | Non-alcoholic fatty liver Severe periodic exercise Low endurance training Protein derived from gene 2 induction of hypoxia intrahepatic fatty |
| url | http://armaghanj.yums.ac.ir/article-1-2215-en.html |
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