Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration
Acquiring high-performance calcium phosphate (CaP) ceramics via 3D printing is critical for their applications in bone regenerative repair. In current study, a complete process study of 3D printed CaP ceramics based on digital light processing (DLP) technology was performed to get the ideal implant...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523006457 |
| _version_ | 1827804751963619328 |
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| author | Yonghao Wu Quanle Cao Yilei Wang Yunyi Liu Xiujuan Xu Puxin Liu Xiangfeng Li Xiangdong Zhu Xingdong Zhang |
| author_facet | Yonghao Wu Quanle Cao Yilei Wang Yunyi Liu Xiujuan Xu Puxin Liu Xiangfeng Li Xiangdong Zhu Xingdong Zhang |
| author_sort | Yonghao Wu |
| collection | DOAJ |
| description | Acquiring high-performance calcium phosphate (CaP) ceramics via 3D printing is critical for their applications in bone regenerative repair. In current study, a complete process study of 3D printed CaP ceramics based on digital light processing (DLP) technology was performed to get the ideal implant for the regenerative repair of calvarial defects. The smaller particle size of initial powder would be more favorable to getting slurry with high solid content and low viscosity. CaP green body with high precision and high curing rate could be fabricated at the exposure energy density and exposure time of 6.20 mJ cm−2 and 2 s, respectively. Moreover, the post-curing treatment could eliminate the interlayer cracks and increase the curing rate from 69.78% to 93.91% of green body. After that, the mechanical strength of CaP ceramics increased by 46.34%. In-vitro cellular experiments showed that 3D printed CaP ceramics had good biocompatibility, and could promote the osteoblastic differentiation of BMSCs. In-vivo rat cranial defect implantation revealed 3D printed CaP ceramics exhibited better osteogenic ability than the commercial ones (BAM®), reaching the close level with the autografts. Overall, this study could provide a closed-loop solution for 3D printed CaP ceramics with high-precision and low-defect to induce bone regeneration. |
| first_indexed | 2024-03-11T21:15:34Z |
| format | Article |
| id | doaj.art-0aa8cbb3bec940e1bdf39f4038cccc6a |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T21:15:34Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-0aa8cbb3bec940e1bdf39f4038cccc6a2023-09-29T04:43:28ZengElsevierMaterials & Design0264-12752023-09-01233112230Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regenerationYonghao Wu0Quanle Cao1Yilei Wang2Yunyi Liu3Xiujuan Xu4Puxin Liu5Xiangfeng Li6Xiangdong Zhu7Xingdong Zhang8National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China; Corresponding authors at: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China; Corresponding authors at: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China; NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterials & Institute of Regulatory Science for Medical Devices & NMPA Research Base of Regulatory Science for Medical Devices, Sichuan University, Chengdu 610064, ChinaAcquiring high-performance calcium phosphate (CaP) ceramics via 3D printing is critical for their applications in bone regenerative repair. In current study, a complete process study of 3D printed CaP ceramics based on digital light processing (DLP) technology was performed to get the ideal implant for the regenerative repair of calvarial defects. The smaller particle size of initial powder would be more favorable to getting slurry with high solid content and low viscosity. CaP green body with high precision and high curing rate could be fabricated at the exposure energy density and exposure time of 6.20 mJ cm−2 and 2 s, respectively. Moreover, the post-curing treatment could eliminate the interlayer cracks and increase the curing rate from 69.78% to 93.91% of green body. After that, the mechanical strength of CaP ceramics increased by 46.34%. In-vitro cellular experiments showed that 3D printed CaP ceramics had good biocompatibility, and could promote the osteoblastic differentiation of BMSCs. In-vivo rat cranial defect implantation revealed 3D printed CaP ceramics exhibited better osteogenic ability than the commercial ones (BAM®), reaching the close level with the autografts. Overall, this study could provide a closed-loop solution for 3D printed CaP ceramics with high-precision and low-defect to induce bone regeneration.http://www.sciencedirect.com/science/article/pii/S02641275230064573D printingCalcium phosphate ceramicsProcess optimizationHigh performanceBone regeneration |
| spellingShingle | Yonghao Wu Quanle Cao Yilei Wang Yunyi Liu Xiujuan Xu Puxin Liu Xiangfeng Li Xiangdong Zhu Xingdong Zhang Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration Materials & Design 3D printing Calcium phosphate ceramics Process optimization High performance Bone regeneration |
| title | Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration |
| title_full | Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration |
| title_fullStr | Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration |
| title_full_unstemmed | Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration |
| title_short | Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration |
| title_sort | optimized fabrication of dlp based 3d printing calcium phosphate ceramics with high precision and low defect to induce calvarial defect regeneration |
| topic | 3D printing Calcium phosphate ceramics Process optimization High performance Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523006457 |
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