The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role
The pineal gland functions as a neuroendocrine transducer that coordinate the organism response to changing environmental stimuli such as light and temperature. The main and best known pineal neurohormone is melatonin that is synthesized and released in a circadian fashion with a peak during the nig...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1987-01-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000600012 |
| _version_ | 1797712515075932160 |
|---|---|
| author | Georges J. M. Maestroni Ario Conti Walter Pierpaoli |
| author_facet | Georges J. M. Maestroni Ario Conti Walter Pierpaoli |
| author_sort | Georges J. M. Maestroni |
| collection | DOAJ |
| description | The pineal gland functions as a neuroendocrine transducer that coordinate the organism response to changing environmental stimuli such as light and temperature. The main and best known pineal neurohormone is melatonin that is synthesized and released in a circadian fashion with a peak during the night darkness hours. We have recently reported that melatonin exerts important immuno regulatory functions. Here we describe the astonishing property of exogenous melatonin which is able to counteract completely the depressive effect of anxiety-restraint stress and/or of corticosterone on thymus weight, andibody production and antiviral responses. This effect seems to be mediated by antigen-activated T cells via an opiatergic mechanism. |
| first_indexed | 2024-03-12T07:22:54Z |
| format | Article |
| id | doaj.art-0aabb84531db4a7cbe4583e780ecbe51 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:22:54Z |
| publishDate | 1987-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-0aabb84531db4a7cbe4583e780ecbe512023-09-02T22:15:01ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601987-01-0182757910.1590/S0074-02761987000600012The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory roleGeorges J. M. MaestroniArio ContiWalter PierpaoliThe pineal gland functions as a neuroendocrine transducer that coordinate the organism response to changing environmental stimuli such as light and temperature. The main and best known pineal neurohormone is melatonin that is synthesized and released in a circadian fashion with a peak during the night darkness hours. We have recently reported that melatonin exerts important immuno regulatory functions. Here we describe the astonishing property of exogenous melatonin which is able to counteract completely the depressive effect of anxiety-restraint stress and/or of corticosterone on thymus weight, andibody production and antiviral responses. This effect seems to be mediated by antigen-activated T cells via an opiatergic mechanism.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000600012 |
| spellingShingle | Georges J. M. Maestroni Ario Conti Walter Pierpaoli The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role Memorias do Instituto Oswaldo Cruz |
| title | The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role |
| title_full | The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role |
| title_fullStr | The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role |
| title_full_unstemmed | The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role |
| title_short | The pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role |
| title_sort | pineal neurohormone melatonin and its physiologic opiatergic immunoregulatory role |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000600012 |
| work_keys_str_mv | AT georgesjmmaestroni thepinealneurohormonemelatoninanditsphysiologicopiatergicimmunoregulatoryrole AT arioconti thepinealneurohormonemelatoninanditsphysiologicopiatergicimmunoregulatoryrole AT walterpierpaoli thepinealneurohormonemelatoninanditsphysiologicopiatergicimmunoregulatoryrole AT georgesjmmaestroni pinealneurohormonemelatoninanditsphysiologicopiatergicimmunoregulatoryrole AT arioconti pinealneurohormonemelatoninanditsphysiologicopiatergicimmunoregulatoryrole AT walterpierpaoli pinealneurohormonemelatoninanditsphysiologicopiatergicimmunoregulatoryrole |