Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats
Background: Tranylcypromine is a monoamine oxidase inhibitor. It inhibits the breakdown of dopamine, serotonin, epinephrine and other monoamines. The aim of this study was to investigate the adverse effects of trarylcypromine on the spermatogenesis in adult male rats. Methods: In this study, 50 adu...
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| Format: | Article |
| Language: | English |
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Arak University of Medical Sciences
2019-02-01
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| Series: | Iranian Journal of Toxicology |
| Subjects: | |
| Online Access: | http://ijt.arakmu.ac.ir/article-1-732-en.pdf |
| _version_ | 1819085156256841728 |
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| author | Mahboobeh Gholamzadeh Mehrdad Shariati* Davood Moghadamnia |
| author_facet | Mahboobeh Gholamzadeh Mehrdad Shariati* Davood Moghadamnia |
| author_sort | Mahboobeh Gholamzadeh |
| collection | DOAJ |
| description | Background: Tranylcypromine is a monoamine oxidase inhibitor. It inhibits the breakdown of dopamine, serotonin, epinephrine and other monoamines. The aim of this study was to investigate the adverse effects of trarylcypromine on the spermatogenesis in adult male rats.
Methods: In this study, 50 adults male Wistar rats, weighing 200-250g, were used and divided into 5 groups of 10. Control group that was not given the treatment; the sham group received normal saline as a solvent and the experimental groups 1, 2 and 3 received 10, 20 and 40 mg/kg of trarylcypromine orally for 21 days. At the end of the trial period, the testes of rats were removed, tissue sections were prepared, stained with hematoxylin and eosin, and the histological features were examined under light microscopy. The statistical analyses performed were ANOVA and Tukey tests, using SPSS software, version 19.
Results: The results demonstrated that the number of spermatogonials, primary spermatocytes, spermatids and Leydig cells in the experimental groups 2 and 3 receiving tranylcypromine significantly decreased compared to those in the control group. However, the number of Sertoli cells in the experimental groups did not change significantly at any dose of the drug compared to those in the control group (P≤0.05).
Conclusion: Tranylcypromine reduced spermatogenesis and the respective indices in rat testicular tissues. |
| first_indexed | 2024-12-21T20:59:52Z |
| format | Article |
| id | doaj.art-0ab0a9eb35fd4aaabd1d914fcdeb6e69 |
| institution | Directory Open Access Journal |
| issn | 2008-2967 2251-9459 |
| language | English |
| last_indexed | 2024-12-21T20:59:52Z |
| publishDate | 2019-02-01 |
| publisher | Arak University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Toxicology |
| spelling | doaj.art-0ab0a9eb35fd4aaabd1d914fcdeb6e692022-12-21T18:50:28ZengArak University of Medical SciencesIranian Journal of Toxicology2008-29672251-94592019-02-01131912Effect of Tranylcypromine on Spermatogenesis in Adult Male RatsMahboobeh Gholamzadeh 0Mehrdad Shariati*1Davood Moghadamnia 2Department of Biology, Shiraz Branch, Islamic Azad University. Shiraz, Iran.Department of Biology, Kazerun Branch, Islamic Azad University. Kazerun, Iran. *Corresponding Author: E-mail: mehrdad.shariati412@gmail.comPhD of Animal Physiology, Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University. Shiraz, Iran.Background: Tranylcypromine is a monoamine oxidase inhibitor. It inhibits the breakdown of dopamine, serotonin, epinephrine and other monoamines. The aim of this study was to investigate the adverse effects of trarylcypromine on the spermatogenesis in adult male rats. Methods: In this study, 50 adults male Wistar rats, weighing 200-250g, were used and divided into 5 groups of 10. Control group that was not given the treatment; the sham group received normal saline as a solvent and the experimental groups 1, 2 and 3 received 10, 20 and 40 mg/kg of trarylcypromine orally for 21 days. At the end of the trial period, the testes of rats were removed, tissue sections were prepared, stained with hematoxylin and eosin, and the histological features were examined under light microscopy. The statistical analyses performed were ANOVA and Tukey tests, using SPSS software, version 19. Results: The results demonstrated that the number of spermatogonials, primary spermatocytes, spermatids and Leydig cells in the experimental groups 2 and 3 receiving tranylcypromine significantly decreased compared to those in the control group. However, the number of Sertoli cells in the experimental groups did not change significantly at any dose of the drug compared to those in the control group (P≤0.05). Conclusion: Tranylcypromine reduced spermatogenesis and the respective indices in rat testicular tissues.http://ijt.arakmu.ac.ir/article-1-732-en.pdfMale Adult RatsSpermatogenesis |
| spellingShingle | Mahboobeh Gholamzadeh Mehrdad Shariati* Davood Moghadamnia Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats Iranian Journal of Toxicology Male Adult Rats Spermatogenesis |
| title | Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats |
| title_full | Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats |
| title_fullStr | Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats |
| title_full_unstemmed | Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats |
| title_short | Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats |
| title_sort | effect of tranylcypromine on spermatogenesis in adult male rats |
| topic | Male Adult Rats Spermatogenesis |
| url | http://ijt.arakmu.ac.ir/article-1-732-en.pdf |
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