Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae)
Species within the genus <i>Rhoicissus</i> (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of <i>Rhoicissus</i> species covering the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/8/2306 |
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| author | Nondumiso P. Dube Xavier Siwe-Noundou Rui W. M. Krause Douglas Kemboi Vuyelwa Jacqueline Tembu Amanda-Lee Manicum |
| author_facet | Nondumiso P. Dube Xavier Siwe-Noundou Rui W. M. Krause Douglas Kemboi Vuyelwa Jacqueline Tembu Amanda-Lee Manicum |
| author_sort | Nondumiso P. Dube |
| collection | DOAJ |
| description | Species within the genus <i>Rhoicissus</i> (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of <i>Rhoicissus</i> species covering the period 1981–2020. The data reported were systematically collected, read, and analysed from scientific electronic databases including Scopus, Scifinder, Pubmed, and Google Scholar. Reported evidence indicates that species in this genus are used for the treatment of gastrointestinal complaints, sexually transmitted infections (STIs), and infertility, as well as to tone the uterus during pregnancy and to facilitate delivery. Pharmacological studies have further shown that members of the <i>Rhoicissus</i> genus display antidiabetic, uterotonic, ascaricidal, hepatoprotective, antioxidant, antimicrobial, anticancer, and anti-inflammatory properties. They are linked to the presence of bioactive compounds isolated from the genus. Hence, <i>Rhoicissus</i> species can potentially be an alternative therapeutic strategy to treat diseases and develop safer and more potent drugs to combat diseases. Plant species of this genus have valuable medicinal benefits due to their significant pharmacological potential. However, scientific investigation and information of the therapeutic potential of <i>Rhoicissus</i> remain limited as most of the species in the genus have not been fully exploited. Therefore, there is a need for further investigations to exploit the therapeutic potential of the genus <i>Rhoicissus</i>. Future studies should evaluate the phytochemical, pharmacological, and toxicological activities, as well as the mode of action, of <i>Rhoicissus</i> crude extracts and secondary compounds isolated from the species. |
| first_indexed | 2024-03-10T12:16:59Z |
| format | Article |
| id | doaj.art-0ab1cd269f1e4cec8af7d365d14825fb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:16:59Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0ab1cd269f1e4cec8af7d365d14825fb2023-11-21T15:47:12ZengMDPI AGMolecules1420-30492021-04-01268230610.3390/molecules26082306Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae)Nondumiso P. Dube0Xavier Siwe-Noundou1Rui W. M. Krause2Douglas Kemboi3Vuyelwa Jacqueline Tembu4Amanda-Lee Manicum5Department of Chemistry, Tshwane University of Technology, 175 Nelson Mandela Drive, Private Bag X680, Pretoria 0001, South AfricaDepartment of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South AfricaDepartment of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South AfricaDepartment of Chemistry, Tshwane University of Technology, 175 Nelson Mandela Drive, Private Bag X680, Pretoria 0001, South AfricaDepartment of Chemistry, Tshwane University of Technology, 175 Nelson Mandela Drive, Private Bag X680, Pretoria 0001, South AfricaDepartment of Chemistry, Tshwane University of Technology, 175 Nelson Mandela Drive, Private Bag X680, Pretoria 0001, South AfricaSpecies within the genus <i>Rhoicissus</i> (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of <i>Rhoicissus</i> species covering the period 1981–2020. The data reported were systematically collected, read, and analysed from scientific electronic databases including Scopus, Scifinder, Pubmed, and Google Scholar. Reported evidence indicates that species in this genus are used for the treatment of gastrointestinal complaints, sexually transmitted infections (STIs), and infertility, as well as to tone the uterus during pregnancy and to facilitate delivery. Pharmacological studies have further shown that members of the <i>Rhoicissus</i> genus display antidiabetic, uterotonic, ascaricidal, hepatoprotective, antioxidant, antimicrobial, anticancer, and anti-inflammatory properties. They are linked to the presence of bioactive compounds isolated from the genus. Hence, <i>Rhoicissus</i> species can potentially be an alternative therapeutic strategy to treat diseases and develop safer and more potent drugs to combat diseases. Plant species of this genus have valuable medicinal benefits due to their significant pharmacological potential. However, scientific investigation and information of the therapeutic potential of <i>Rhoicissus</i> remain limited as most of the species in the genus have not been fully exploited. Therefore, there is a need for further investigations to exploit the therapeutic potential of the genus <i>Rhoicissus</i>. Future studies should evaluate the phytochemical, pharmacological, and toxicological activities, as well as the mode of action, of <i>Rhoicissus</i> crude extracts and secondary compounds isolated from the species.https://www.mdpi.com/1420-3049/26/8/2306botany<i>cuneifolia</i>pharmacologyphytochemistry<i>Rhoicissus</i>Vitaceae |
| spellingShingle | Nondumiso P. Dube Xavier Siwe-Noundou Rui W. M. Krause Douglas Kemboi Vuyelwa Jacqueline Tembu Amanda-Lee Manicum Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae) Molecules botany <i>cuneifolia</i> pharmacology phytochemistry <i>Rhoicissus</i> Vitaceae |
| title | Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae) |
| title_full | Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae) |
| title_fullStr | Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae) |
| title_full_unstemmed | Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae) |
| title_short | Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of <i>Rhoicissus</i> Species (Vitaceae) |
| title_sort | review of the traditional uses phytochemistry and pharmacological activities of i rhoicissus i species vitaceae |
| topic | botany <i>cuneifolia</i> pharmacology phytochemistry <i>Rhoicissus</i> Vitaceae |
| url | https://www.mdpi.com/1420-3049/26/8/2306 |
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