A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms
Abstract Advances in biomarker detection have acclaimed a new era of biosensors that enable continuous monitoring of health status, device miniaturization, and wearability. This transition toward integrated, wearable biosensors has necessitated the co‐development of novel materials that can adequate...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-03-01
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| Series: | Advanced Sensor Research |
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| Online Access: | https://doi.org/10.1002/adsr.202300122 |
| _version_ | 1827323689122660352 |
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| author | Erfan Shirzadi Michelle Huynh Peyman GhavamiNejad Hanjia Zheng Agosh Saini Fatemeh Bakhshandeh Fatemeh Keyvani Dragos Mantaila Fasih A. Rahman Joe Quadrilatero Leyle Soleymani Mahla Poudineh |
| author_facet | Erfan Shirzadi Michelle Huynh Peyman GhavamiNejad Hanjia Zheng Agosh Saini Fatemeh Bakhshandeh Fatemeh Keyvani Dragos Mantaila Fasih A. Rahman Joe Quadrilatero Leyle Soleymani Mahla Poudineh |
| author_sort | Erfan Shirzadi |
| collection | DOAJ |
| description | Abstract Advances in biomarker detection have acclaimed a new era of biosensors that enable continuous monitoring of health status, device miniaturization, and wearability. This transition toward integrated, wearable biosensors has necessitated the co‐development of novel materials that can adequately support the operation of these devices. In this study, a novel type of electrode is presented that is suitable for use in wearable electrochemical biosensors. The electrode is constructed using a biocompatible composite hydrogel and takes the form of a hydrogel microneedle (HMN) patch. It is specifically designed for analyzing interstitial fluid. The HMN electrode is a combination of poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), a highly conductive polymer, and graphene oxide, incorporated into a crosslinked hydrogel network of methacrylated hyaluronic acid. To ensure the successful penetration of the skin, the fabrication process is carefully optimized to create sharp needles. To assess the performance of the HMN electrode, electrochemical tests are conducted using an ex vivo porcine skin model. Additionally, HMN electrode's suitability is demonstrated as the working electrode of a wearable electrochemical biosensor for in vivo measurement using a rat model. The findings highlight the advancement of the HMN electrode array as an alternative to solid microneedles, representing the next generation of polymeric electrodes. |
| first_indexed | 2024-04-25T01:57:02Z |
| format | Article |
| id | doaj.art-0ab238036d7347d1b1c51b76940e7f49 |
| institution | Directory Open Access Journal |
| issn | 2751-1219 |
| language | English |
| last_indexed | 2024-04-25T01:57:02Z |
| publishDate | 2024-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj.art-0ab238036d7347d1b1c51b76940e7f492024-03-07T15:47:28ZengWiley-VCHAdvanced Sensor Research2751-12192024-03-0133n/an/a10.1002/adsr.202300122A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing PlatformsErfan Shirzadi0Michelle Huynh1Peyman GhavamiNejad2Hanjia Zheng3Agosh Saini4Fatemeh Bakhshandeh5Fatemeh Keyvani6Dragos Mantaila7Fasih A. Rahman8Joe Quadrilatero9Leyle Soleymani10Mahla Poudineh11Department of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Engineering Physics McMaster University Hamilton ON L8S 4L8 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Kinesiology and Health Sciences University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Kinesiology and Health Sciences University of Waterloo Waterloo ON N2L 3G1 CanadaDepartment of Engineering Physics McMaster University Hamilton ON L8S 4L8 CanadaDepartment of Electrical and Computer Engineering University of Waterloo Waterloo ON N2L 3G1 CanadaAbstract Advances in biomarker detection have acclaimed a new era of biosensors that enable continuous monitoring of health status, device miniaturization, and wearability. This transition toward integrated, wearable biosensors has necessitated the co‐development of novel materials that can adequately support the operation of these devices. In this study, a novel type of electrode is presented that is suitable for use in wearable electrochemical biosensors. The electrode is constructed using a biocompatible composite hydrogel and takes the form of a hydrogel microneedle (HMN) patch. It is specifically designed for analyzing interstitial fluid. The HMN electrode is a combination of poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), a highly conductive polymer, and graphene oxide, incorporated into a crosslinked hydrogel network of methacrylated hyaluronic acid. To ensure the successful penetration of the skin, the fabrication process is carefully optimized to create sharp needles. To assess the performance of the HMN electrode, electrochemical tests are conducted using an ex vivo porcine skin model. Additionally, HMN electrode's suitability is demonstrated as the working electrode of a wearable electrochemical biosensor for in vivo measurement using a rat model. The findings highlight the advancement of the HMN electrode array as an alternative to solid microneedles, representing the next generation of polymeric electrodes.https://doi.org/10.1002/adsr.202300122conductive hydrogel microneedleelectrochemical measurementinterstitial fluidPEDOT:PSSwearable biosensing |
| spellingShingle | Erfan Shirzadi Michelle Huynh Peyman GhavamiNejad Hanjia Zheng Agosh Saini Fatemeh Bakhshandeh Fatemeh Keyvani Dragos Mantaila Fasih A. Rahman Joe Quadrilatero Leyle Soleymani Mahla Poudineh A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms Advanced Sensor Research conductive hydrogel microneedle electrochemical measurement interstitial fluid PEDOT:PSS wearable biosensing |
| title | A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms |
| title_full | A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms |
| title_fullStr | A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms |
| title_full_unstemmed | A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms |
| title_short | A PEDOT:PSS‐Based Composite Hydrogel as a Versatile Electrode for Wearable Microneedle Sensing Platforms |
| title_sort | pedot pss based composite hydrogel as a versatile electrode for wearable microneedle sensing platforms |
| topic | conductive hydrogel microneedle electrochemical measurement interstitial fluid PEDOT:PSS wearable biosensing |
| url | https://doi.org/10.1002/adsr.202300122 |
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