Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast
Background: Chronic Kidney Disease (CKD) is a global public health problem with increasing prevalence and a substantial burden on healthcare systems. The characteristics of rapid progressors and factors that may predict accelerated CKD progression require further exploration, especially since there...
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| Format: | Article |
| Language: | English |
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Asociación Colombiana de Nefrología e Hipertensión Arterial
2023-08-01
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| Series: | Revista Colombiana de Nefrología |
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| Online Access: | https://revistanefrologia.org/index.php/rcn/article/view/630 |
| _version_ | 1797734415340666880 |
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| author | Angela J Pereira-Morales Walberto Buelvas Víctor de la Espriella Albert Montenegro Luis H Rojas William Amador |
| author_facet | Angela J Pereira-Morales Walberto Buelvas Víctor de la Espriella Albert Montenegro Luis H Rojas William Amador |
| author_sort | Angela J Pereira-Morales |
| collection | DOAJ |
| description |
Background: Chronic Kidney Disease (CKD) is a global public health problem with increasing prevalence and a substantial burden on healthcare systems. The characteristics of rapid progressors and factors that may predict accelerated CKD progression require further exploration, especially since there are no published studies about this topic in Colombia.
Purpose: To identify the clinical and sociodemographic factors associated with the rapid progression of CKD in a large cohort of Colombian patients.
Methods: This retrospective observational study included two cohorts of G1 to G4 stage CKD patients without dialysis from the Colombian North Coast. Follow-up was conducted for 18 months (n=14,420) and 24 months (n=10,042). Patients were divided into rapid progressors and stable progressors based on the glomerular filtration rate (GFR) slope <?5 mL/min/1.73m2/year or ?-5 mL/min/1.73 m2/year, respectively.
Results: 37.68% of the cohort was classified as rapid progressors at 24 months and 28.41% at 18 months. An R2=0.77 was found in both cohorts for GFR measurements, indicating a linear trend toward loss. Furthermore, accelerated progression was observed in younger patients and those with higher diastolic blood pressure values. Conclusion: In two large cohorts of renal patients, approximately 4 out of 10 patients were classified as rapid progressors at 24 months of follow-up and 3 out of 10 at 18 months of follow-up. It is important to identify patients at higher risk of accelerated CKD progression in the short term to provide them with personalized and effective care.
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| first_indexed | 2024-03-12T12:42:59Z |
| format | Article |
| id | doaj.art-0ab36561df34490d9f001e9c90a849b5 |
| institution | Directory Open Access Journal |
| issn | 2500-5006 |
| language | English |
| last_indexed | 2024-03-12T12:42:59Z |
| publishDate | 2023-08-01 |
| publisher | Asociación Colombiana de Nefrología e Hipertensión Arterial |
| record_format | Article |
| series | Revista Colombiana de Nefrología |
| spelling | doaj.art-0ab36561df34490d9f001e9c90a849b52023-08-28T23:40:48ZengAsociación Colombiana de Nefrología e Hipertensión ArterialRevista Colombiana de Nefrología2500-50062023-08-0110110.22265/acnef.10.1.630Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean CoastAngela J Pereira-Morales0Walberto Buelvas1Víctor de la Espriella2Albert Montenegro3Luis H Rojas4William Amador5Science for Life-S4L SAS, Bogotá, ColombiaMedisinú IPS, Montería, ColombiaMedisinú IPS, Montería, ColombiaScience for Life-S4L SAS, Bogotá, ColombiaScience for Life-S4L SAS, Bogotá, ColombiaScience for Life-S4L SAS, Bogotá, Colombia Background: Chronic Kidney Disease (CKD) is a global public health problem with increasing prevalence and a substantial burden on healthcare systems. The characteristics of rapid progressors and factors that may predict accelerated CKD progression require further exploration, especially since there are no published studies about this topic in Colombia. Purpose: To identify the clinical and sociodemographic factors associated with the rapid progression of CKD in a large cohort of Colombian patients. Methods: This retrospective observational study included two cohorts of G1 to G4 stage CKD patients without dialysis from the Colombian North Coast. Follow-up was conducted for 18 months (n=14,420) and 24 months (n=10,042). Patients were divided into rapid progressors and stable progressors based on the glomerular filtration rate (GFR) slope <?5 mL/min/1.73m2/year or ?-5 mL/min/1.73 m2/year, respectively. Results: 37.68% of the cohort was classified as rapid progressors at 24 months and 28.41% at 18 months. An R2=0.77 was found in both cohorts for GFR measurements, indicating a linear trend toward loss. Furthermore, accelerated progression was observed in younger patients and those with higher diastolic blood pressure values. Conclusion: In two large cohorts of renal patients, approximately 4 out of 10 patients were classified as rapid progressors at 24 months of follow-up and 3 out of 10 at 18 months of follow-up. It is important to identify patients at higher risk of accelerated CKD progression in the short term to provide them with personalized and effective care. https://revistanefrologia.org/index.php/rcn/article/view/630Chronic Kidney DiseaseAccelerated Progressionglomerular filtration rateRisk FactorsPublic HealthPrevention |
| spellingShingle | Angela J Pereira-Morales Walberto Buelvas Víctor de la Espriella Albert Montenegro Luis H Rojas William Amador Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast Revista Colombiana de Nefrología Chronic Kidney Disease Accelerated Progression glomerular filtration rate Risk Factors Public Health Prevention |
| title | Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast |
| title_full | Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast |
| title_fullStr | Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast |
| title_full_unstemmed | Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast |
| title_short | Factors Associated with Accelerated Progression of Chronic Kidney Disease in Patients from the Colombian Caribbean Coast |
| title_sort | factors associated with accelerated progression of chronic kidney disease in patients from the colombian caribbean coast |
| topic | Chronic Kidney Disease Accelerated Progression glomerular filtration rate Risk Factors Public Health Prevention |
| url | https://revistanefrologia.org/index.php/rcn/article/view/630 |
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