Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex
Cell type epigenetic and topographic information of primate brain is lacking. Here, authors identified transcriptional regulatory network, gradient expression pattern and disease vulnerability at cell type level in PFC, M1 and V1 of monkey brain by snRNAseq, snATAC-seq and Stereo-seq.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34413-3 |
| _version_ | 1817970793868427264 |
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| author | Ying Lei Mengnan Cheng Zihao Li Zhenkun Zhuang Liang Wu Yunong sun Lei Han Zhihao Huang Yuzhou Wang Zifei Wang Liqin Xu Yue Yuan Shang Liu Taotao Pan Jiarui Xie Chuanyu Liu Giacomo Volpe Carl Ward Yiwei Lai Jiangshan Xu Mingyue Wang Hao Yu Haixi Sun Qichao Yu Liang Wu Chunqing Wang Chi Wai Wong Wei Liu Liangzhi Xu Jingkuan Wei Dandan Chen Zhouchun Shang Guibo Li Kun Ma Le Cheng Fei Ling Tao Tan Kai Chen Bosiljka Tasic Michael Dean Weizhi Ji Huanming Yang Ying Gu Miguel A. Esteban Yuxiang Li Ao Chen Yuyu Niu Hongkui Zeng Yong Hou Longqi Liu Shiping Liu Xun Xu |
| author_facet | Ying Lei Mengnan Cheng Zihao Li Zhenkun Zhuang Liang Wu Yunong sun Lei Han Zhihao Huang Yuzhou Wang Zifei Wang Liqin Xu Yue Yuan Shang Liu Taotao Pan Jiarui Xie Chuanyu Liu Giacomo Volpe Carl Ward Yiwei Lai Jiangshan Xu Mingyue Wang Hao Yu Haixi Sun Qichao Yu Liang Wu Chunqing Wang Chi Wai Wong Wei Liu Liangzhi Xu Jingkuan Wei Dandan Chen Zhouchun Shang Guibo Li Kun Ma Le Cheng Fei Ling Tao Tan Kai Chen Bosiljka Tasic Michael Dean Weizhi Ji Huanming Yang Ying Gu Miguel A. Esteban Yuxiang Li Ao Chen Yuyu Niu Hongkui Zeng Yong Hou Longqi Liu Shiping Liu Xun Xu |
| author_sort | Ying Lei |
| collection | DOAJ |
| description | Cell type epigenetic and topographic information of primate brain is lacking. Here, authors identified transcriptional regulatory network, gradient expression pattern and disease vulnerability at cell type level in PFC, M1 and V1 of monkey brain by snRNAseq, snATAC-seq and Stereo-seq. |
| first_indexed | 2024-04-13T20:38:34Z |
| format | Article |
| id | doaj.art-0ab4d766decf4a70b2a80a3a8ff72b4b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T20:38:34Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0ab4d766decf4a70b2a80a3a8ff72b4b2022-12-22T02:30:57ZengNature PortfolioNature Communications2041-17232022-11-0113112010.1038/s41467-022-34413-3Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortexYing Lei0Mengnan Cheng1Zihao Li2Zhenkun Zhuang3Liang Wu4Yunong sun5Lei Han6Zhihao Huang7Yuzhou Wang8Zifei Wang9Liqin Xu10Yue Yuan11Shang Liu12Taotao Pan13Jiarui Xie14Chuanyu Liu15Giacomo Volpe16Carl Ward17Yiwei Lai18Jiangshan Xu19Mingyue Wang20Hao Yu21Haixi Sun22Qichao Yu23Liang Wu24Chunqing Wang25Chi Wai Wong26Wei Liu27Liangzhi Xu28Jingkuan Wei29Dandan Chen30Zhouchun Shang31Guibo Li32Kun Ma33Le Cheng34Fei Ling35Tao Tan36Kai Chen37Bosiljka Tasic38Michael Dean39Weizhi Ji40Huanming Yang41Ying Gu42Miguel A. Esteban43Yuxiang Li44Ao Chen45Yuyu Niu46Hongkui Zeng47Yong Hou48Longqi Liu49Shiping Liu50Xun Xu51BGI-HangzhouBGI-HangzhouBGI-HangzhouBGI-HangzhouBGI-ShenzhenBGI-HangzhouBGI-HangzhouBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-HangzhouBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-HangzhouHematology and Cell Therapy Unit, IRCCS-Istituto Tumori “Giovanni Paolo II”. Viale O Flacco 65Laboratory of Integrative biology, Guangzhou Institutes of Biomedicine and Health, CASBGI-HangzhouBGI-HangzhouBGI-HangzhouBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenHuazhen BiosciencesHuazhen BiosciencesHuazhen BiosciencesYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyBGI-GenoImmune, BGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-ShenzhenBGI-Yunnan, BGI-ShenzhenSchool of Biology and Biological Engineering, South China University of TechnologyYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyAllen Institute for Brain ScienceCancer and Inflammation Program, National Cancer Institute at Frederick, Building 560Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyBGI-ShenzhenBGI-HangzhouBGI-HangzhouBGI-ShenzhenBGI-ShenzhenYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyAllen Institute for Brain ScienceBGI-ShenzhenBGI-HangzhouBGI-HangzhouBGI-HangzhouCell type epigenetic and topographic information of primate brain is lacking. Here, authors identified transcriptional regulatory network, gradient expression pattern and disease vulnerability at cell type level in PFC, M1 and V1 of monkey brain by snRNAseq, snATAC-seq and Stereo-seq.https://doi.org/10.1038/s41467-022-34413-3 |
| spellingShingle | Ying Lei Mengnan Cheng Zihao Li Zhenkun Zhuang Liang Wu Yunong sun Lei Han Zhihao Huang Yuzhou Wang Zifei Wang Liqin Xu Yue Yuan Shang Liu Taotao Pan Jiarui Xie Chuanyu Liu Giacomo Volpe Carl Ward Yiwei Lai Jiangshan Xu Mingyue Wang Hao Yu Haixi Sun Qichao Yu Liang Wu Chunqing Wang Chi Wai Wong Wei Liu Liangzhi Xu Jingkuan Wei Dandan Chen Zhouchun Shang Guibo Li Kun Ma Le Cheng Fei Ling Tao Tan Kai Chen Bosiljka Tasic Michael Dean Weizhi Ji Huanming Yang Ying Gu Miguel A. Esteban Yuxiang Li Ao Chen Yuyu Niu Hongkui Zeng Yong Hou Longqi Liu Shiping Liu Xun Xu Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex Nature Communications |
| title | Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex |
| title_full | Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex |
| title_fullStr | Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex |
| title_full_unstemmed | Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex |
| title_short | Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex |
| title_sort | spatially resolved gene regulatory and disease related vulnerability map of the adult macaque cortex |
| url | https://doi.org/10.1038/s41467-022-34413-3 |
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