A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint
This review highlights the essential role of Hedgehog (Hh) signalling in the developmental steps of temporomandibular joint (TMJ) formation. We review evidence for intra- and potentially inter-tissue Hh signaling as well as Glioma-Associated Oncogene Homolog (GLI) dependent and independent functions...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2221-3759/4/3/25 |
| _version_ | 1818039254880616448 |
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| author | Malgorzata Kubiak Mark Ditzel |
| author_facet | Malgorzata Kubiak Mark Ditzel |
| author_sort | Malgorzata Kubiak |
| collection | DOAJ |
| description | This review highlights the essential role of Hedgehog (Hh) signalling in the developmental steps of temporomandibular joint (TMJ) formation. We review evidence for intra- and potentially inter-tissue Hh signaling as well as Glioma-Associated Oncogene Homolog (GLI) dependent and independent functions. Morphogenesis and maturation of the TMJ’s individual components and the general landscape of Hh signalling is also covered. Comparison of the appendicular knee and axial TMJ also reveals interesting differences and similarities in their mechanisms of development, chondrogenesis and reliance on Hh signalling. |
| first_indexed | 2024-12-10T07:55:43Z |
| format | Article |
| id | doaj.art-0ab5a79c935e438b84fae1359004326a |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-12-10T07:55:43Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-0ab5a79c935e438b84fae1359004326a2022-12-22T01:56:54ZengMDPI AGJournal of Developmental Biology2221-37592016-08-01432510.3390/jdb4030025jdb4030025A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial JointMalgorzata Kubiak0Mark Ditzel1Edinburgh CRUK Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh EH4 2XR, UKEdinburgh CRUK Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh EH4 2XR, UKThis review highlights the essential role of Hedgehog (Hh) signalling in the developmental steps of temporomandibular joint (TMJ) formation. We review evidence for intra- and potentially inter-tissue Hh signaling as well as Glioma-Associated Oncogene Homolog (GLI) dependent and independent functions. Morphogenesis and maturation of the TMJ’s individual components and the general landscape of Hh signalling is also covered. Comparison of the appendicular knee and axial TMJ also reveals interesting differences and similarities in their mechanisms of development, chondrogenesis and reliance on Hh signalling.http://www.mdpi.com/2221-3759/4/3/25HedgehogHhIndian HedgehogIHHtemporomandibular jointsynovial jointGLI |
| spellingShingle | Malgorzata Kubiak Mark Ditzel A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint Journal of Developmental Biology Hedgehog Hh Indian Hedgehog IHH temporomandibular joint synovial joint GLI |
| title | A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint |
| title_full | A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint |
| title_fullStr | A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint |
| title_full_unstemmed | A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint |
| title_short | A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint |
| title_sort | joint less ordinary intriguing roles for hedgehog signalling in the development of the temporomandibular synovial joint |
| topic | Hedgehog Hh Indian Hedgehog IHH temporomandibular joint synovial joint GLI |
| url | http://www.mdpi.com/2221-3759/4/3/25 |
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