Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody
Abstract This study aimed to evaluate long‐term changes in nailfold videocapillaroscopy (NVC) findings in dermatomyositis patients with antinuclear matrix protein 2 (NXP‐2) antibody (Ab). All four patients with anti‐NXP‐2 Ab presented irregularly enlarged and reduced capillaries and hemorrhages at t...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12334 |
| _version_ | 1797326557918789632 |
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| author | Naoki Mugii Yasuhito Hamaguchi Natsumi Fushida Motoki Horii Tasuku Kitano Ko Fujii Kaori Sawada Kyosuke Oishi Shintaro Maeda Takashi Matsushita |
| author_facet | Naoki Mugii Yasuhito Hamaguchi Natsumi Fushida Motoki Horii Tasuku Kitano Ko Fujii Kaori Sawada Kyosuke Oishi Shintaro Maeda Takashi Matsushita |
| author_sort | Naoki Mugii |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate long‐term changes in nailfold videocapillaroscopy (NVC) findings in dermatomyositis patients with antinuclear matrix protein 2 (NXP‐2) antibody (Ab). All four patients with anti‐NXP‐2 Ab presented irregularly enlarged and reduced capillaries and hemorrhages at the initial assessment. After disease stabilization, irregularly enlarged capillaries and hemorrhages disappeared within the mean observation period of 6 months. These early improvements were not observed in patients with anti‐TIF1 Ab. The results of this study show that long‐term changes in NVC findings should be assessed using myositis‐specific Ab information. |
| first_indexed | 2024-03-08T06:25:57Z |
| format | Article |
| id | doaj.art-0ab835f0c0be4fb7b949f7b4adb9aa51 |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T06:25:57Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-0ab835f0c0be4fb7b949f7b4adb9aa512024-02-03T14:40:20ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932023-12-016624524810.1002/cia2.12334Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibodyNaoki Mugii0Yasuhito Hamaguchi1Natsumi Fushida2Motoki Horii3Tasuku Kitano4Ko Fujii5Kaori Sawada6Kyosuke Oishi7Shintaro Maeda8Takashi Matsushita9Department of Rehabilitation Kanazawa University Hospital Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa JapanAbstract This study aimed to evaluate long‐term changes in nailfold videocapillaroscopy (NVC) findings in dermatomyositis patients with antinuclear matrix protein 2 (NXP‐2) antibody (Ab). All four patients with anti‐NXP‐2 Ab presented irregularly enlarged and reduced capillaries and hemorrhages at the initial assessment. After disease stabilization, irregularly enlarged capillaries and hemorrhages disappeared within the mean observation period of 6 months. These early improvements were not observed in patients with anti‐TIF1 Ab. The results of this study show that long‐term changes in NVC findings should be assessed using myositis‐specific Ab information.https://doi.org/10.1002/cia2.12334anti‐NXP‐2 Abdermatomyositisnailfold capillary changes |
| spellingShingle | Naoki Mugii Yasuhito Hamaguchi Natsumi Fushida Motoki Horii Tasuku Kitano Ko Fujii Kaori Sawada Kyosuke Oishi Shintaro Maeda Takashi Matsushita Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody Journal of Cutaneous Immunology and Allergy anti‐NXP‐2 Ab dermatomyositis nailfold capillary changes |
| title | Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody |
| title_full | Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody |
| title_fullStr | Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody |
| title_full_unstemmed | Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody |
| title_short | Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti‐NXP‐2 antibody |
| title_sort | early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti nxp 2 antibody |
| topic | anti‐NXP‐2 Ab dermatomyositis nailfold capillary changes |
| url | https://doi.org/10.1002/cia2.12334 |
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