Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders
IntroductionTo date, no systematic review or meta-analysis has critically evaluated the relevance of using optokinetic after-nystagmus (OKAN) in diagnosis of vestibular disorders. To assess the role of OKAN in diagnosis of vestibular disorders, the OKAN time constant (TC) between patients with vesti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1367735/full |
| _version_ | 1797322400908443648 |
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| author | Marie Reynders Lynn Van der Sypt Jelte Bos Jelte Bos Wilfried Cools Vedat Topsakal |
| author_facet | Marie Reynders Lynn Van der Sypt Jelte Bos Jelte Bos Wilfried Cools Vedat Topsakal |
| author_sort | Marie Reynders |
| collection | DOAJ |
| description | IntroductionTo date, no systematic review or meta-analysis has critically evaluated the relevance of using optokinetic after-nystagmus (OKAN) in diagnosis of vestibular disorders. To assess the role of OKAN in diagnosis of vestibular disorders, the OKAN time constant (TC) between patients with vestibular disorders and healthy participants will be compared.MethodsAutomated search strategies were carried out in the Embase, Medline PubMed, Web of Science, and Scopus databases from inception to December 2023. The following inclusion criteria were applied: (1) evaluation of OKAN in individuals with vestibular disorders, (2) clinical trials, and (3) inclusion of healthy individuals as the control group. Exclusion criteria were: (1) animal studies, (2) non-clinical trial study designs, (3) assessment of non-vestibular disorders, (4) no examination of OKAN TC, (5) only examination of healthy participants, (6) studies published in a language other than English, (7) no healthy participants as control group, (8) case reports, and (9) only abstract available. The random-effects model was used to pool the data. The Joanna Briggs Institute (JBI) Critical Appraisal Tools was used to assess the risk of bias. The quality assessment was performed with the aid of the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, provided by NHLBI. The PRISMA guidelines were used as reporting guidelines. The main outcome of this study was the between-group mean difference (MDbetween) in OKAN TC and its 95% confidence interval between patients with vestibular disorders and healthy participants.ResultsSeven out of 244 screened articles were included that studied 289 participants. The overall mean difference (MD = −7.08) with a 95% CI of [−10.18; −3.97] was significant (p = 0.014). The heterogeneity was significant (p = 0.02). Quality assessment was generally good (76%). The risk of bias was low in five studies and moderate in two studies.ConclusionThe results demonstrate that OKAN TC is significantly shorter in patients with vestibular disorders compared to healthy controls. This finding is important for future research, particularly with the emergence of novel clinical tools and diagnostic syndromes.Systematic Reviewhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=442695. |
| first_indexed | 2024-03-08T05:12:46Z |
| format | Article |
| id | doaj.art-0ab8546f7a414d6483714c0fd437e5c9 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-08T05:12:46Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0ab8546f7a414d6483714c0fd437e5c92024-02-07T04:55:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-02-011510.3389/fneur.2024.13677351367735Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disordersMarie Reynders0Lynn Van der Sypt1Jelte Bos2Jelte Bos3Wilfried Cools4Vedat Topsakal5Department of Otorhinolaryngology and Head and Neck Surgery, Vrije Universiteit Brussel, Hospital UZ Brussel, Brussels Health Campus, Brussels, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Vrije Universiteit Brussel, Hospital UZ Brussel, Brussels Health Campus, Brussels, BelgiumHuman Performance, Netherlands Organization for Applied Scientific Research (TNO), Soesterberg, NetherlandsDepartment of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsInterfaculty Center for Data Processing & Statistics, Vrije Universiteit Brussel (VUB), Brussels, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Vrije Universiteit Brussel, Hospital UZ Brussel, Brussels Health Campus, Brussels, BelgiumIntroductionTo date, no systematic review or meta-analysis has critically evaluated the relevance of using optokinetic after-nystagmus (OKAN) in diagnosis of vestibular disorders. To assess the role of OKAN in diagnosis of vestibular disorders, the OKAN time constant (TC) between patients with vestibular disorders and healthy participants will be compared.MethodsAutomated search strategies were carried out in the Embase, Medline PubMed, Web of Science, and Scopus databases from inception to December 2023. The following inclusion criteria were applied: (1) evaluation of OKAN in individuals with vestibular disorders, (2) clinical trials, and (3) inclusion of healthy individuals as the control group. Exclusion criteria were: (1) animal studies, (2) non-clinical trial study designs, (3) assessment of non-vestibular disorders, (4) no examination of OKAN TC, (5) only examination of healthy participants, (6) studies published in a language other than English, (7) no healthy participants as control group, (8) case reports, and (9) only abstract available. The random-effects model was used to pool the data. The Joanna Briggs Institute (JBI) Critical Appraisal Tools was used to assess the risk of bias. The quality assessment was performed with the aid of the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, provided by NHLBI. The PRISMA guidelines were used as reporting guidelines. The main outcome of this study was the between-group mean difference (MDbetween) in OKAN TC and its 95% confidence interval between patients with vestibular disorders and healthy participants.ResultsSeven out of 244 screened articles were included that studied 289 participants. The overall mean difference (MD = −7.08) with a 95% CI of [−10.18; −3.97] was significant (p = 0.014). The heterogeneity was significant (p = 0.02). Quality assessment was generally good (76%). The risk of bias was low in five studies and moderate in two studies.ConclusionThe results demonstrate that OKAN TC is significantly shorter in patients with vestibular disorders compared to healthy controls. This finding is important for future research, particularly with the emergence of novel clinical tools and diagnostic syndromes.Systematic Reviewhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=442695.https://www.frontiersin.org/articles/10.3389/fneur.2024.1367735/fullVertigonystagmus analysisoptokinetic (OKN) systemoptokinetic after-nystagmusvestibular neuritisbilateral vestibular areflexia |
| spellingShingle | Marie Reynders Lynn Van der Sypt Jelte Bos Jelte Bos Wilfried Cools Vedat Topsakal Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders Frontiers in Neurology Vertigo nystagmus analysis optokinetic (OKN) system optokinetic after-nystagmus vestibular neuritis bilateral vestibular areflexia |
| title | Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders |
| title_full | Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders |
| title_fullStr | Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders |
| title_full_unstemmed | Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders |
| title_short | Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders |
| title_sort | systematic review and meta analysis of the diagnostic value of optokinetic after nystagmus in vestibular disorders |
| topic | Vertigo nystagmus analysis optokinetic (OKN) system optokinetic after-nystagmus vestibular neuritis bilateral vestibular areflexia |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1367735/full |
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