The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register
Abstract Background The ten-joint juvenile arthritis disease activity score (JADAS10) is designed to measure the level of disease activity in non-systemic juvenile idiopathic arthritis by providing a single numeric score. The clinical JADAS10 (cJADAS10) is a modification of the JADAS10 that excludes...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00814-x |
| _version_ | 1797845988147200000 |
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| author | M. Backström H. Salo J. Kärki K. Aalto K. Rebane T. Levälampi M-M. Grönlund L. Kröger H. Pohjankoski M. Hietanen K. Korkatti L. Kuusalo V. Rantalaiho J. Huhtakangas H. Relas T. Pääkkö E. Löyttyniemi T. Sokka-Isler P. Vähäsalo |
| author_facet | M. Backström H. Salo J. Kärki K. Aalto K. Rebane T. Levälampi M-M. Grönlund L. Kröger H. Pohjankoski M. Hietanen K. Korkatti L. Kuusalo V. Rantalaiho J. Huhtakangas H. Relas T. Pääkkö E. Löyttyniemi T. Sokka-Isler P. Vähäsalo |
| author_sort | M. Backström |
| collection | DOAJ |
| description | Abstract Background The ten-joint juvenile arthritis disease activity score (JADAS10) is designed to measure the level of disease activity in non-systemic juvenile idiopathic arthritis by providing a single numeric score. The clinical JADAS10 (cJADAS10) is a modification of the JADAS10 that excludes erythrocyte sedimentation rate (ESR). Three different sets of JADAS10/cJADAS10 cut-offs for disease activity states have been published, i.e., the Backström, Consolaro, and Trincianti cut-offs. The objective of this study was to investigate the performance of existing JADAS10 cut-offs in real-life settings using patient data from The Finnish Rheumatology Quality Register (FinRheuma). Methods Data were collected from the FinRheuma register. The proportion of patients with an active joint count (AJC) above zero when classified as being in clinically inactive disease (CID) or low disease activity (LDA) groups according to existing JADAS10/cJADAS10 cut-off levels were analyzed. Results A significantly larger proportion of the patients classified as being in CID had an AJC > 0 when using the JADAS10/cJADAS10 cut-offs by Trincianti et al. compared to those for the other cut-offs. In the LDA group, a significantly larger proportion of the polyarticular patients (35%/29%) had an AJC of two when Trincianti JADAS10/cJADAS10 cut-offs were used compared with when Backström (11%/10%) and Consolaro (7%/3%) JADAS10/cJADAS10 cut-offs were used. Conclusions We found the cut-offs proposed by Consolaro et al. to be the most feasible, since these cut-off levels for CID do not result in the misclassification of active disease as remission, and the proportion of patients with AJC > 1 in the LDA group is lowest using these cut-offs. |
| first_indexed | 2024-04-09T17:48:52Z |
| format | Article |
| id | doaj.art-0aba8d85ad0b41cda4f88b22f9b5463a |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-04-09T17:48:52Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-0aba8d85ad0b41cda4f88b22f9b5463a2023-04-16T11:09:11ZengBMCPediatric Rheumatology Online Journal1546-00962023-04-012111910.1186/s12969-023-00814-xThe feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality RegisterM. Backström0H. Salo1J. Kärki2K. Aalto3K. Rebane4T. Levälampi5M-M. Grönlund6L. Kröger7H. Pohjankoski8M. Hietanen9K. Korkatti10L. Kuusalo11V. Rantalaiho12J. Huhtakangas13H. Relas14T. Pääkkö15E. Löyttyniemi16T. Sokka-Isler17P. Vähäsalo18Department of Paediatrics, The Wellbeing Services County of OstrobothniaKnowledge Brokers Department, Finnish Institute for Health and WelfareDepartment of Children and Adolescents, Kanta-Häme Central HospitalNew Children’s Hospital, Pediatric Research Center, Helsinki University Hospital and University of HelsinkiNew Children’s Hospital, Pediatric Research Center, Helsinki University Hospital and University of HelsinkiNew Children’s Hospital, Pediatric Research Center, Helsinki University Hospital and University of HelsinkiDepartment of Paediatrics, Turku University HospitalDepartment of Children and Adolescents, Kuopio University HospitalDepartment of Children and Adolescents, Päijät-Häme Central HospitalDepartment of Children and Adolescents, Päijät-Häme Central HospitalDepartment of Paediatrics, Central Ostrobothnia Central HospitalCentre for Rheumatology and Clinical Immunology, Division of Medicine, University of Turku and Turku University HospitalFaculty of Medicine and Health Technology, Tampere UniversityDivision of Rheumatology, Kuopio University HospitalDepartment of Rheumatology, Inflammation Center, Helsinki University Hospital, and University of HelsinkiDepartment of Internal Medicine, Oulu University HospitalDepartment of Biostatistics, University of TurkuUniversity of Eastern Finland, Kuopio and Central Finland Central HospitalPEDEGO Research Unit, University of OuluAbstract Background The ten-joint juvenile arthritis disease activity score (JADAS10) is designed to measure the level of disease activity in non-systemic juvenile idiopathic arthritis by providing a single numeric score. The clinical JADAS10 (cJADAS10) is a modification of the JADAS10 that excludes erythrocyte sedimentation rate (ESR). Three different sets of JADAS10/cJADAS10 cut-offs for disease activity states have been published, i.e., the Backström, Consolaro, and Trincianti cut-offs. The objective of this study was to investigate the performance of existing JADAS10 cut-offs in real-life settings using patient data from The Finnish Rheumatology Quality Register (FinRheuma). Methods Data were collected from the FinRheuma register. The proportion of patients with an active joint count (AJC) above zero when classified as being in clinically inactive disease (CID) or low disease activity (LDA) groups according to existing JADAS10/cJADAS10 cut-off levels were analyzed. Results A significantly larger proportion of the patients classified as being in CID had an AJC > 0 when using the JADAS10/cJADAS10 cut-offs by Trincianti et al. compared to those for the other cut-offs. In the LDA group, a significantly larger proportion of the polyarticular patients (35%/29%) had an AJC of two when Trincianti JADAS10/cJADAS10 cut-offs were used compared with when Backström (11%/10%) and Consolaro (7%/3%) JADAS10/cJADAS10 cut-offs were used. Conclusions We found the cut-offs proposed by Consolaro et al. to be the most feasible, since these cut-off levels for CID do not result in the misclassification of active disease as remission, and the proportion of patients with AJC > 1 in the LDA group is lowest using these cut-offs.https://doi.org/10.1186/s12969-023-00814-xJuvenile idiopathic arthritisOutcome measuresDisease activity |
| spellingShingle | M. Backström H. Salo J. Kärki K. Aalto K. Rebane T. Levälampi M-M. Grönlund L. Kröger H. Pohjankoski M. Hietanen K. Korkatti L. Kuusalo V. Rantalaiho J. Huhtakangas H. Relas T. Pääkkö E. Löyttyniemi T. Sokka-Isler P. Vähäsalo The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register Pediatric Rheumatology Online Journal Juvenile idiopathic arthritis Outcome measures Disease activity |
| title | The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register |
| title_full | The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register |
| title_fullStr | The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register |
| title_full_unstemmed | The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register |
| title_short | The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register |
| title_sort | feasibility of existing jadas10 cut off values in clinical practice a study of data from the finnish rheumatology quality register |
| topic | Juvenile idiopathic arthritis Outcome measures Disease activity |
| url | https://doi.org/10.1186/s12969-023-00814-x |
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