Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies
ABSTRACTObjective: This study was to comprehensively clarify the associations between single nucleotide polymorphisms (SNPs) in inflammatory genes and the susceptibility to childhood leukemia.Methods: Eligible articles were collected from the databases of PubMed, EMBASE, Cochrane Library, CNKI and W...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2023.2210905 |
| _version_ | 1797826666934829056 |
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| author | Qiuping Zeng Haoyan Ren Cui Liu Ting Liu Yongwu Xie Xiufu Tang |
| author_facet | Qiuping Zeng Haoyan Ren Cui Liu Ting Liu Yongwu Xie Xiufu Tang |
| author_sort | Qiuping Zeng |
| collection | DOAJ |
| description | ABSTRACTObjective: This study was to comprehensively clarify the associations between single nucleotide polymorphisms (SNPs) in inflammatory genes and the susceptibility to childhood leukemia.Methods: Eligible articles were collected from the databases of PubMed, EMBASE, Cochrane Library, CNKI and Wan Fang. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimate the association strength by using the STATA 15.0 software.Results: Sixteen studies were enrolled. These studies mainly evaluated SNPs in 13 genes, including C-X-C motif chemokine ligand 12 (CXCL12), toll-like receptor (TLR)−4, TLR6, TLR9, CD14, interleukin (IL)−1β, NLR family pyrin domain containing 3, IL-4, interleukin 4 receptor, IL-10, IL-13, macrophage migration inhibitory factor (MIF) and tumor necrosis factor-α. The meta-analysis indicated that CXCL12 rs1801157 (AG vs GG: OR = 1.99; 95%CI = 1.20–3.30; p = 0.008; AA + AG vs GG: OR = 1.92; 95%CI = 1.18–3.12; p = 0.009), TLR6 rs5743810 (TC vs TT: OR = 0.58; 95%CI = 0.39–0.85; p = 0.005), IL-10 rs1800871 (TC vs CC: OR = 1.19; 95%CI = 1.01–1.41; p = 0.044), rs1800872 (AC vs AA: OR = 1.53; 95%CI = 1.22–1.92; p < 0.001) and MIF rs755622 (CG versus GG: OR = 1.33; 95%CI = 1.07–1.67; p = 0.012) polymorphisms were associated with the risk of childhood leukemia. No significant correlations were found between SNPs in other genes and the childhood leukemia risk. Subgroup analyses of rs1800871 and rs1800872 confirmed the conclusions obtained in their overall meta-analytical processes.Conclusion: CXCL12 rs1801157, TLR6 rs5743810, IL-10 rs1800871, rs1800872 and MIF rs755622 polymorphisms may represent candidate biomarkers for the risk prediction of childhood leukemia. |
| first_indexed | 2024-04-09T12:36:04Z |
| format | Article |
| id | doaj.art-0abbb8b5feda43a4a8a83764f65d44fe |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2024-04-09T12:36:04Z |
| publishDate | 2023-12-01 |
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| series | Hematology |
| spelling | doaj.art-0abbb8b5feda43a4a8a83764f65d44fe2023-05-15T10:42:07ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2023.2210905Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studiesQiuping Zeng0Haoyan Ren1Cui Liu2Ting Liu3Yongwu Xie4Xiufu Tang5Department of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal and Child Health Care, Zhuhai, People’s Republic of ChinaDepartment of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal and Child Health Care, Zhuhai, People’s Republic of ChinaDepartment of Pediatrics, Qingdao Huangdao District Central Hospital, Qingdao, People’s Republic of ChinaDepartment of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal and Child Health Care, Zhuhai, People’s Republic of ChinaDepartment of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal and Child Health Care, Zhuhai, People’s Republic of ChinaDepartment of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal and Child Health Care, Zhuhai, People’s Republic of ChinaABSTRACTObjective: This study was to comprehensively clarify the associations between single nucleotide polymorphisms (SNPs) in inflammatory genes and the susceptibility to childhood leukemia.Methods: Eligible articles were collected from the databases of PubMed, EMBASE, Cochrane Library, CNKI and Wan Fang. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimate the association strength by using the STATA 15.0 software.Results: Sixteen studies were enrolled. These studies mainly evaluated SNPs in 13 genes, including C-X-C motif chemokine ligand 12 (CXCL12), toll-like receptor (TLR)−4, TLR6, TLR9, CD14, interleukin (IL)−1β, NLR family pyrin domain containing 3, IL-4, interleukin 4 receptor, IL-10, IL-13, macrophage migration inhibitory factor (MIF) and tumor necrosis factor-α. The meta-analysis indicated that CXCL12 rs1801157 (AG vs GG: OR = 1.99; 95%CI = 1.20–3.30; p = 0.008; AA + AG vs GG: OR = 1.92; 95%CI = 1.18–3.12; p = 0.009), TLR6 rs5743810 (TC vs TT: OR = 0.58; 95%CI = 0.39–0.85; p = 0.005), IL-10 rs1800871 (TC vs CC: OR = 1.19; 95%CI = 1.01–1.41; p = 0.044), rs1800872 (AC vs AA: OR = 1.53; 95%CI = 1.22–1.92; p < 0.001) and MIF rs755622 (CG versus GG: OR = 1.33; 95%CI = 1.07–1.67; p = 0.012) polymorphisms were associated with the risk of childhood leukemia. No significant correlations were found between SNPs in other genes and the childhood leukemia risk. Subgroup analyses of rs1800871 and rs1800872 confirmed the conclusions obtained in their overall meta-analytical processes.Conclusion: CXCL12 rs1801157, TLR6 rs5743810, IL-10 rs1800871, rs1800872 and MIF rs755622 polymorphisms may represent candidate biomarkers for the risk prediction of childhood leukemia.https://www.tandfonline.com/doi/10.1080/16078454.2023.2210905Childhood leukemiapolymorphisminflammationIL-10meta-analysis |
| spellingShingle | Qiuping Zeng Haoyan Ren Cui Liu Ting Liu Yongwu Xie Xiufu Tang Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies Hematology Childhood leukemia polymorphism inflammation IL-10 meta-analysis |
| title | Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies |
| title_full | Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies |
| title_fullStr | Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies |
| title_full_unstemmed | Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies |
| title_short | Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies |
| title_sort | polymorphisms of inflammation related genes and susceptibility to childhood leukemia evidence from a meta analysis of 16 published studies |
| topic | Childhood leukemia polymorphism inflammation IL-10 meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2023.2210905 |
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