Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study
<i>Background and objectives</i>: Kisspeptin, also named metastin, showed important roles in initiating the secretion of gonadotropin-releasing hormone (GnRH) and is an essential factor in the development of polycystic ovaries syndrome (PCOS). Several research studies noticed association...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/6/776 |
| _version_ | 1797484519135117312 |
|---|---|
| author | Mona Akad Răzvan Socolov Cristina Furnică Roxana Covali Catalina Daniela Stan Eduard Crauciuc Ioana Pavaleanu |
| author_facet | Mona Akad Răzvan Socolov Cristina Furnică Roxana Covali Catalina Daniela Stan Eduard Crauciuc Ioana Pavaleanu |
| author_sort | Mona Akad |
| collection | DOAJ |
| description | <i>Background and objectives</i>: Kisspeptin, also named metastin, showed important roles in initiating the secretion of gonadotropin-releasing hormone (GnRH) and is an essential factor in the development of polycystic ovaries syndrome (PCOS). Several research studies noticed associations between kisspeptin levels and patients with anovulatory cycles due to PCOS with an increased LH/FSH ratio. The aim of our study was to bring scientific evidence regarding the correlation between high kisspeptin and luteinizing hormone values in subfertile women due to PCOS. <i>Materials and Methods:</i> A prospective case-control study was conducted in “Elena Doamna” Hospital of Obstetrics and Gynecology between 4 January 2021 and 1 March 2022. All patients agreed to participate in our study, had ages between 18 and 45 years old, and had a body mass index between 18.5 and 30 kg/m<sup>2</sup>. The study group consisted of subfertile patients with PCOS and menstrual disturbances, including amenorrhea or oligomenorrhea. The control group consisted of healthy patients with ovulatory cycles and no other reproductive or endocrinology pathologies. During the follicular phase of their menstrual cycle, patients had blood samples taken with the dosage of kisspeptin, LH, FSH, estradiol, insulin, glycemic levels, testosterone, and prolactin. Pelvic ultrasounds and clinical examinations were performed as well. <i>Results</i>: Significant differences were observed in kisspeptin, LH, FSH, and estradiol levels between patients with PCOS and the control group. After the univariate analysis, PCOS was significantly associated with increased kisspeptin, increased LH, and decreased FSH. There was no significant association between PCOS, estradiol, prolactin, and insulin. <i>Conclusions</i>: kisspeptin serum values are higher in subfertile PCOS patients, supporting the hypothesis that an over-stimulation of the KISS1 system might cause the hyper-stimulation of the HPG-axis. |
| first_indexed | 2024-03-09T23:06:31Z |
| format | Article |
| id | doaj.art-0abbd8aea0324ae8a9b03bad8f7c3d23 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:06:31Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-0abbd8aea0324ae8a9b03bad8f7c3d232023-11-23T17:52:24ZengMDPI AGMedicina1010-660X1648-91442022-06-0158677610.3390/medicina58060776Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control StudyMona Akad0Răzvan Socolov1Cristina Furnică2Roxana Covali3Catalina Daniela Stan4Eduard Crauciuc5Ioana Pavaleanu6Department of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iași, Romania<i>Background and objectives</i>: Kisspeptin, also named metastin, showed important roles in initiating the secretion of gonadotropin-releasing hormone (GnRH) and is an essential factor in the development of polycystic ovaries syndrome (PCOS). Several research studies noticed associations between kisspeptin levels and patients with anovulatory cycles due to PCOS with an increased LH/FSH ratio. The aim of our study was to bring scientific evidence regarding the correlation between high kisspeptin and luteinizing hormone values in subfertile women due to PCOS. <i>Materials and Methods:</i> A prospective case-control study was conducted in “Elena Doamna” Hospital of Obstetrics and Gynecology between 4 January 2021 and 1 March 2022. All patients agreed to participate in our study, had ages between 18 and 45 years old, and had a body mass index between 18.5 and 30 kg/m<sup>2</sup>. The study group consisted of subfertile patients with PCOS and menstrual disturbances, including amenorrhea or oligomenorrhea. The control group consisted of healthy patients with ovulatory cycles and no other reproductive or endocrinology pathologies. During the follicular phase of their menstrual cycle, patients had blood samples taken with the dosage of kisspeptin, LH, FSH, estradiol, insulin, glycemic levels, testosterone, and prolactin. Pelvic ultrasounds and clinical examinations were performed as well. <i>Results</i>: Significant differences were observed in kisspeptin, LH, FSH, and estradiol levels between patients with PCOS and the control group. After the univariate analysis, PCOS was significantly associated with increased kisspeptin, increased LH, and decreased FSH. There was no significant association between PCOS, estradiol, prolactin, and insulin. <i>Conclusions</i>: kisspeptin serum values are higher in subfertile PCOS patients, supporting the hypothesis that an over-stimulation of the KISS1 system might cause the hyper-stimulation of the HPG-axis.https://www.mdpi.com/1648-9144/58/6/776kisspeptinpolycystic ovary syndromeinfertility |
| spellingShingle | Mona Akad Răzvan Socolov Cristina Furnică Roxana Covali Catalina Daniela Stan Eduard Crauciuc Ioana Pavaleanu Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study Medicina kisspeptin polycystic ovary syndrome infertility |
| title | Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study |
| title_full | Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study |
| title_fullStr | Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study |
| title_full_unstemmed | Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study |
| title_short | Kisspeptin Variations in Patients with Polycystic Ovary Syndrome—A Prospective Case Control Study |
| title_sort | kisspeptin variations in patients with polycystic ovary syndrome a prospective case control study |
| topic | kisspeptin polycystic ovary syndrome infertility |
| url | https://www.mdpi.com/1648-9144/58/6/776 |
| work_keys_str_mv | AT monaakad kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy AT razvansocolov kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy AT cristinafurnica kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy AT roxanacovali kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy AT catalinadanielastan kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy AT eduardcrauciuc kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy AT ioanapavaleanu kisspeptinvariationsinpatientswithpolycysticovarysyndromeaprospectivecasecontrolstudy |